Rémunération des commissaires aux comptes : problème de limites de la mission légale et contentieux pour des travaux externes

<p>Data are shown as mean values and standard deviations. There were no significant differences in baseline levels. IL-10 production in the Terli and Vaso groups increased more significantly than in the LR or Sham groups (P<0.001) but there was no significant difference of serum levels of IL-10 between the Terli and Vaso groups.</p

A Comparison of Vasopressin, Terlipressin, and Lactated Ringers for Resuscitation of Uncontrolled Hemorrhagic Shock in an Animal Model

<div><p>Aim</p><p>The aim of this study is to compare the effect of lactated ringer (LR), vasopressin (Vaso) or terlipressin (Terli) on uncontrolled hemorrhagic shock (UHS) in rats.</p><p>Methods</p><p>48 rats were divided into four treatment groups for UHS study. Vaso group was given bolus vasopressin (0.8 U/kg); the Terli group was given bolus terlipressin (15 mcg/kg); LR group was given LR and the sham group was not given anything. Mean arterial pressure (MAP), serum lactate level, plasma cytokine levels, lung injury and mortality are investigated for these different treatment groups.</p><p>Results</p><p>Compared with LR group, vasopressin and terlipressin-treated groups were associated with higher MAP, lowered mortality rates, less lung injury, lowered serum lactate level, less proinflammatory and more anti-inflammatory cytokine production at certain time points. Comparing between vasopressin and terlipressin treated groups, there is no statistical difference in mortality rates, lung injury, serum lactate level and cytokine level. However, there is a difference in the length of time in maintaining a restored level of MAP (80 to 110 mmHg). The terlipressin treated rats can maintain this restored level of MAP for 45 minutes, but the vasopressin treated rats can only maintain this restored level of MAP for 5 minutes before decreasing gradually to the MAP observed in LR group (40 mmHg).</p><p>Conclusion</p><p>Early optimization of hemodynamics with terlipressin or vasopressin in an animal model of UHS was associated with improved hemodynamics and inflammatory cytokine profile than the LR control. Compared with vasopressin, terlipressin has the advantage of ease of use and sustained effects.</p></div

Comparison of serum lactate levels between different resuscitation strategies groups from 0 to 135 min.

<p>Data are shown as mean values and standard deviations. There were no significant differences in baseline levels. The Terli group had significantly lower serum lactate level than Vaso or LR group at 60 and 90</p

Histologic variables with regard to pulmonary edema formation and interstitial cell infiltration.

<p><i>A</i>, Edema score, significant comparisons: Terli vs. LR (p = 0.027) or Vaso vs. LR (p = 0.01). <i>B</i>, Cell infiltration score, significant comparisons Terli vs. LR (p = 0.020) or Vaso vs. LR (p = 0.031). The Sham group showed significant lower pathologic scores than all other resuscitation groups (<i>P<0.001</i>).</p

Experimental protocol and mean arterial pressure over time in four treatment groups.

<p>The MAP for the sham group is around 110</p

Comparison of serum TNF-alpha levels between different resuscitation strategies groups from 0 to 135 min.

<p>Data are shown as mean values and standard deviations. There were no significant differences in baseline levels and the serum TNF-alpha levels over time.</p