Phenotype-based and Self-learning Inter-individual Sleep Apnea Screening with a Level IV Monitoring System

Purpose: We propose a phenotype-based artificial intelligence system that can self-learn and is accurate for screening purposes, and test it on a Level IV monitoring system. Methods: Based on the physiological knowledge, we hypothesize that the phenotype information will allow us to find subjects from a well-annotated database that share similar sleep apnea patterns. Therefore, for a new-arriving subject, we can establish a prediction model from the existing database that is adaptive to the subject. We test the proposed algorithm on a database consisting of 62 subjects with the signals recorded from a Level IV wearable device measuring the thoracic and abdominal movements and the SpO2. Results: With the leave-one cross validation, the accuracy of the proposed algorithm to screen subjects with an apnea-hypopnea index greater or equal to 15 is 93.6%, the positive likelihood ratio is 6.8, and the negative likelihood ratio is 0.03. Conclusion: The results confirm the hypothesis and show that the proposed algorithm has great potential to screen patients with SAS

A consistent and unified picture for critical phenomena of f(R)f(R) AdS black holes

A consistent and unified picture for critical phenomena of charged AdS black holes in $f(R)$ gravity is drawn in this paper. Firstly, we investigate the phase transition in canonical ensemble. We derive the explicit solutions corresponding to the divergence of $C_Q$. The two solutions merge into one when the condition $Q_c=\sqrt{\frac{-1}{3R_0}}$ is satisfied. The curve of specific heat for $Q<Q_c$ has two divergent points and can be divided into three regions. Both the large radius region and the small radius region are thermodynamically stable with positive specific heat while the medium radius region is unstable with negative specific heat. However, when $Q>Q_c$, the specific heat is always positive, implying the black holes are locally stable and no phase transition will take place. Secondly, both the $T-r_+$ curve and $T-S$ curve $f(R)$ AdS black holes are investigated and they exhibit Van der Vaals like behavior as the $P-v$ curve in the former research. Critical physical quantities are obtained and they are consistent with those derived from the specific heat analysis. We carry out numerical check of Maxwell equal area law for the cases $Q=0.2Q_c, 0.4Q_c, 0.6Q_c, 0.8Q_c$. The relative errors are amazingly small and can be negligible. So the Maxwell equal area law holds for $T-S$ curve of $f(R)$ black holes. Thirdly, we establish geometrothermodynamics for $f(R)$ AdS black hole to examine the phase structure. It is shown that the Legendre invariant scalar curvature $\mathfrak{R}$ would diverge exactly where the specific heat diverges. To summarize, the above three perspectives are consistent with each other, thus providing a unified picture which deepens the understanding of critical phenomena of $f(R)$ AdS black holes.Comment: More discussions added in the Conclusion Section. 14pages, 10figure

The relationship between metabolic rate and sociability is altered by food-deprivation

Individuals vary in the extent to which they associate with conspecifics, but little is known about the energetic underpinnings of this variation in sociability. Group-living allows individuals to find food more consistently, but within groups, there can be competition for food items. Individuals with an increased metabolic rate could display decreased sociability to reduce competition. Long-term food deprivation (FD) may alter any links between sociability and metabolic rate by affecting motivation to find food. We examined these issues in juvenile qingbo carp Spinibarbus sinensis, to understand how FD and metabolic rate affect sociability. Like many aquatic ectotherms, this species experiences seasonal bouts of FD. Individuals were either: (i) food-deprived for 21 days; or (ii) fed a maintenance ration (control). Fish from each treatment were measured for standard metabolic rate (SMR) and tested for sociability twice: once in the presence of a control stimulus shoal and once with a food-deprived stimulus shoal. Control individuals ventured further from stimulus shoals over a 30-min trial, while food-deprived fish did not change their distance from stimulus shoals as trials progressed. Control fish with a higher SMR were least sociable. Well-fed controls showed decreased sociability when exposed to food-deprived stimulus shoals, but there was evidence of consistency in relative sociability between exposures to different shoal types. Results contrast with previous findings that several days of fasting causes individuals to decrease associations with conspecifics. Prolonged FD may cause individuals to highly prioritize food acquisition, and the decreased vigilance that would accompany continuous foraging may heighten the need for the antipredator benefits of shoaling. Conversely, decreased sociability in well-fed fish with a high SMR probably minimizes intraspecific competition, allowing them to satisfy an increased energetic demand while foraging. Together, these results suggest that FD – a challenge common for many ectothermic species – can affect individual sociability as well as the attractiveness of groups towards conspecifics. In addition, the lack of a link between SMR and sociability in food-deprived fish suggests that, in situations where group membership is linked to fitness, the extent of correlated selection on metabolic traits may be context-dependent