3,947 research outputs found

    PDB5 CAN USE OF GLITAZONES REDUCE THE RISK OF ALZHEIMER'S DISEASE IN PATIENTS WITH DIABETES?

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    Gate controlled electronic transport in monolayer MoS2 field effect transistor

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    Intra-orbital distance as a record of social brain dysmorphology in autism

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    Minor Physical Anomalies (MPAs) arise during the first trimester of prenatal life and occur more frequently in autism and related neurodevelopmental disorders. We measured intra-orbital distances from T1 weighted images of children with autism aged 6 – 16 years and typically developing peers. We report a significant increase in intra-orbital distance in autism. Using voxel-wise linear regression analysis intra-orbital distances were found to positively correlate with the volume of inferio-temporal regions including the amygdala in the autism group only. We suggest that intra-orbital MPA may provide a ‘fossil’ record of much earlier childhood brain expansion in autism.published_or_final_versionThe 19th Annual Meeting of the International Society for Magnetic Resonance in Medicine (ISMRM), Montreal, Canada, 7-13 May 2011. In Proceedings of the 19th ISMRM, 2011, p. 252

    Prta: A System to Support the Analysis of Propaganda Techniques in the News

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    Recent events, such as the 2016 US Presidential Campaign, Brexit and the COVID-19 "infodemic", have brought into the spotlight the dangers of online disinformation. There has been a lot of research focusing on fact-checking and disinformation detection. However, little attention has been paid to the specific rhetorical and psychological techniques used to convey propaganda messages. Revealing the use of such techniques can help promote media literacy and critical thinking, and eventually contribute to limiting the impact of "fake news" and disinformation campaigns.Prta (Propaganda Persuasion Techniques Analyzer) allows users to explore the articles crawled on a regular basis by highlighting the spans in which propaganda techniques occur and to compare them on the basis of their use of propaganda techniques. The system further reports statistics about the use of such techniques, overall and over time, or according to filtering criteria specified by the user based on time interval, keywords, and/or political orientation of the media. Moreover, it allows users to analyze any text or URL through a dedicated interface or via an API. The system is available online: https://www.tanbih.org/prta

    Dynamic dyssynchrony and impaired contractile reserve of the left ventricle in beta-thalassaemia major: an exercise echocardiographic study

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    BACKGROUND: Performance of the left ventricle during exercise stress in thalassaemia patients is uncertain. We aimed to explore the phenomenon of dynamic dyssynchrony and assess contractile reserve in patients with beta-thalassaemia major and determine their relationships with myocardial iron load. METHODS AND RESULTS: Thirty-two thalassaemia patients (16 males), aged 26.8+/-6.9 years, without heart failure and 17 healthy controls were studied. Their left ventricular (LV) volumes, ejection fraction, systolic dyssynchrony index (SDI), and myocardial acceleration during isovolumic LV contraction (IVA) were determined at rest and during submaximal bicycle exercise testing using 3-dimensional and tissue Doppler echocardiography. Myocardial iron load as assessed by T2* cardiac magnetic resonance in patients were further related to indices of LV dyssynchrony and contractile reserve. At rest, patients had significantly greater LV SDI (p4.6%, control+2SD) increased from baseline 25% to 84% in patients. Delta SDI(exercise-baseline) correlated with exercise-baseline differences in LV ejection fraction (p<0.001) and stroke volume (p = 0.006). Compared with controls, patients had significantly less exercise-induced increase in LV ejection fraction, cardiac index, and IVA (interaction, all p<0.05) and had impaired contractile reserve as reflected by the gentler IVA-heart rate slope (p = 0.018). Cardiac T2* in patients correlated with baseline LV SDI (r = -0.44, p = 0.011) and IVA-heart rate slope (r = 0.36, p = 0.044). CONCLUSIONS: Resting LV dyssynchrony is associated with myocardial iron load. Exercise stress further unveils LV dynamic dyssynchrony and impaired contractile reserve in patients with beta-thalassaemia major.published_or_final_versio

    MRI brain scan study of minor physical anomalies to aid the early diagnosis of autism

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    Poster Sessionspublished_or_final_versionThe 27th International College of Neuropsychopharmacology Congress (CINP 2010), Hong Kong, China, 6-10 June 2010. In International Journal of Neuropsychopharmacology, 2010, v. 13, suppl. S1, p. 182, abstract no. P-14.03
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