Remarkable hydrostatic piezoelectric response of novel 2–0–2 composites

This is the first study of the significant influence of the 0–3 ceramic / polymer layer on the hydrostatic piezoelectric parameters of novel 2–0–2 relaxor-ferroelectric single crystal / ferroelectric ceramic / polymer composites. Examples of the performance of two 2–0–2 composites based on domain-engineered single crystals are analysed by taking into account the elastic anisotropy of the 0–3 ceramic/polymer layers with changes in the volume fraction of ceramic inclusions and their aspect ratio. The unique feature of the hydrostatic properties of the studied 2–0–2 composites consists in their large values of piezoelectric coefficients d*h ≈ 1 nC/N and e*h ≈ 20 C/m2, squared figure of merit d*hg*h∼ 10−10 Pa−1, and electromechanical coupling factor k*h ≈ 0.7.</p

Дослідження безпосередніх та віддалених результатів комплексного лікування хворих з місцево-розповсюдженим раком молочної залози з використанням системної та ендолімфатичної поліхіміотерапії в неоад'ювантному режимі

Мета. Порівняти безпосередні та віддалені результати лікування хворих з місцево-розповсюдженим раком молочної залози (МР РМЗ) з використанням різних способів введення препаратів поліхіміотерапії (ПХТ). Матеріали і методи. Дослідження проведено на основі вибіркового аналізу медичних карт 112 стаціонарних хворих з МР РМЗ стадії T4A-DN0-3M0, які отримували комплексне протипухлинне лікування на базі Донецького обласного протипухлинного центру та Університетської клініки Одеського національного медичного університету в 2000 - 2017 рр. До контрольної групи увійшли 65 (58%) пацієнток з неоперабельними формами МР РМЗ, яким у неоад’ювантному режимі була проведена системна ПХТ (СПХТ). До досліджуваної групи увійшли 47 (42%) пацієнток з неоперабельними формами МР РМЗ, яким як неоад’ювантний курс була проведена ендолімфатична ПХТ (ЕЛПХТ). Результати. За показниками три- та пۥятирічної виживаності між контрольною і досліджуваною групами не було статистично значущої відмінності. Безпосередні результати лікування пацієнток, яким проведена ЕЛПХТ у неоад’ювантому режимі, кращі, ніж результати лікування пацієнток, яким проведена СПХТ, без статистично значущої переваги. Висновки. Безпосередні і віддалені результати комплексного лікування МР РМЗ у разі несприятливого прогнозу пухлинного росту з проведенням ЕЛПХТ у неоад'ювантному режимі і виконанням радикального оперативного втручання кращі в порівнянні з результатами лікування за аналогічною схемою, але з проведенням СПХТ на передопераційному етапі, без статистично значущої переваги

Comorbidity of tics and epilepsy in children and adolescents

Tics are the most common forms of hyperkinesis among children and adolescents, the etiology of which is not fully clear. A study has shown a high comorbidity of tic disorders and epilepsy, as evidenced by video-EEG monitoring. In patients with tics even in the absence of epileptic seizures, epileptiform activity is an adverse predictor and a determinant of the potential risk of comorbid epilepsy especially during neuroleptic therapy. Antiepileptic drugs are the drugs of choice to treat this category of patients

Application of marker of proliferative activity Ki-67 for analysis of efficacy in complex treatment of patients, suffering locally-spread mammary gland cancer

Objective. Application of the proliferative activity marker Ki-67 for analysis of the results of neoadjuvant polychemotherapy, using regional or systemic ways of delivery of pharmacological preparations, for the patients, suffering locally spread mammary gland cancer (LS MGC). Materials and methods. Retrospective analysis of the data, concerning 90 women-patients, suffering LS MGC, who obtained complex treatment, based on regional and systemic ways of the preparations administration. Results. Dynamics of proliferative activity of a LS MGC as a result of neoadjuvant polychemotherapy, analyzed by the Ki-67 level determination, have demonstrated a statistically significant advantage of regional ways of the preparation injection, comparing with systemic ways of administration. Correlation of tumoral metastatic potential with level of Ki-67 was revealed, using detailed investigation. Conclusion. It is possible to estimate tumoral proliferative activity and the neoadjuvant polychemotherapy efficacy, using Ki-67 analysis, and in such a way to select the optimal tactics of complex treatment

Enchanced preoperative rehabilitation as part of the complex perioperative rehabilitation of patients with super-obesity and obstructive sleep apnea syndrome (clinical outlook)

Obesity is a global social and economic problem. The bariatric surgery is a most effective treatment for obesity. The presented clinical case demonstrates the usage of principles of enchanced perioperative rehabilitation for the preoperative preparation of a patient with super obesity and with severe obstructive sleep apnea and alveolar hypoventilation syndrome.A 54-year-old patient was hospitalized with complaints of obesity, impossibility of persistent weight loss conservatively, severe daytime sleepiness, frequent nocturnal awakenings (up to 8 times per night). The patient’s weight was 230 kg with a height of 157 cm (BMI 93.5 kg / m2). The examination revealed a syndrome of sleep apnea of mixed genesis of extremely severe degree, chronic night hypoxemia of an extremely severe degree. Preoperative preparation was performed in accordance with the program of enchanced perioperative rehabilitation. The duration of preoperative preparation was 19 days; weight loss — 40 kg (%WL -17,4), compensation of comorbidities was achieved as well. After that the patient underwent a laparoscopic sleeve gastrectomy. There were no complications in the postoperative period. Length of postoperative hospital stay was 6 days. At follow-up examination one year after surgery, body weight dropped from 230 to 153 kg (% WL-33.5), a significant improvement of the quality of life was achieved.The enchanced perioperative rehabilitation program can be successfully used as an effective method for preoperartive preparation of the patients with morbid obesity in combination with severe obstructive sleep apnea syndrome.and obesity hypoventilation. It can be a reasonable alternative to the standard program with preoperative intragastric balloon treatment. The use of this technique allows to increase the effectiveness of treatment of these high-risk patients, as well as to reduce the risk of perioperative complications

Повышение коэффициента мощности выпрямителя с помощью входного пассивного фильтра

The cutting-edge IT devices widely use rectifiers (secondary power supply sources). The literature gives fairly good considerations concerning the secondary power supply design. At the same time, the impact of the rectifier performance on the line current and on the quality of electric power is less studied. Capacitive filters used to smooth the output voltage cause distortions of the input current. Such rectifiers consume the short pulse current from the line at the interval of charging capacity, thereby leading to emerging minority harmonic components in the input current; these components are multiple of majority harmonics.This lowers a power factor of the rectifier and deteriorates quality of line power. To increase the power factor and reduce the amplitude of minority harmonics of the input current, are used passive and active input filters. Passive input filters are used for small loads of low power. The paper proposes a technique to calculate the rectifier input current waveform and its spectral composition, which is necessary for calculating the parameters of a passive noise filter. The analysis of the efficiency of a typical passive filter to improve power factor and reduce minority harmonics of the line current has been conducted. The simulation has shown that passive noise filter at the input of the rectifier increases the power factor by less than 10%, that is significantly less than in using the active filter.В статье рассматривается проблема искажения формы сетевого тока выпрямителя, что приводит к уменьшению коэффициента мощности. На основе теоретических исследований разработана методика вычисления формы сетевого тока и его спектрального состава для выпрямителя с сглаживающим емкостным фильтром. Подтверждено, что увеличение емкости фильтра (уменьшение пульсаций выходного напряжения) приводит к существенному увеличению амплитуды неосновных гармоник во входном токе выпрямителя и снижению коэффициента мощности. С помощью пакета моделирования электронных схем Multisim исследовано влияние входного типового пассивного LC-фильтра на спектральный состав входного тока и коэффициент мощности. Показано, что использование пассивного фильтра снижает амплитуды неосновных гармоник и повышает коэффициент мощности. Однако коэффициент мощности повышается не более чем на 10%, что существенно меньше чем при использовании активного фильтра. Поэтому использование пассивных входных фильтров целесообразно только для маломощных устройств. DOI: 10.7463/rdopt.0615.082608

Properties of Neutral Charmed Mesons in Proton--Nucleus Interactions at 70 GeV

The results of treatment of data obtained in the SERP-E-184experiment "Investigation of mechanisms of the production of charmed particles in proton-nucleus interactions at 70 GeV and their decays" by irradiating the active target of the SVD-2 facility consisting of carbon, silicon, and lead plates, are presented. After separating a signal from the two-particle decay of neutral charmed mesons and estimating the cross section for charm production at a threshold energy {\sigma}(c\v{c})=7.1 \pm 2.4(stat.) \pm 1.4(syst.) \mub/nucleon, some properties of D mesons are investigated. These include the dependence of the cross section on the target mass number (its A dependence); the behavior of the differential cross sections d{\sigma}/dpt2 and d{\sigma}/dxF; and the dependence of the parameter {\alpha} on the kinematical variables xF, pt2, and plab. The experimental results in question are compared with predictions obtained on the basis of the FRITIOF7.02 code.Comment: 9 pages, 9 figures,3 table

OBTAINING OF MOLYBDENUM OXYCARBIDE IN CONDITIONS OF PLASMA RECONDENSATION IN A LOW-TEMPERATURE NITROGEN PLASMA OF MECHANICAL MIXTURE OF MOLYBDENUM AND UREA

Методом плазмохимического синтеза по схеме плазменной переконденсации в низкотемпературной азотной плазме из механической смеси металлического молибдена и мочевины получен нанокристаллический порошок оксикарбида молибдена со структурой типа NaCl, который был аттестован методами рентгенографии, растровой электронной микроскопии и энргодисперсионного анализа.A nanocrystalline powder of oxycarbide molybdenum with a NaCl structure was obtained by the method of plasma-chemical synthesis according to the plasma-recondensation scheme in a low-temperature nitrogen plasma from the mechanical mixture of metallic molybdenum and urea, which was certified by X-ray diffraction, scanning electron microscopy, and energy-dispersive analysis.Авторы выражают благодарность канд. техн. наук Э. К. Добринскому (ФГУП ГНИИХТЭОС) за помощь в проведении экспериментов по плазменной переконденсации механической смеси молибдена и мочевины

The first record of natural transfer of mitochondrial DNA from Pelophylax cf. bedriagae into P. lessonae (Amphibia, Anura)

The unidirectional natural transfer of mitochondrial (mt) DNA from Pelophylax lessonae into P. ridibundus is a common phenomenon in central Europe. Cases of mtDNA exchange between P. lessonae and other non-clonal species of the genus Pelophylax have been unknown so far. In this paper, we describe the first case of mtDNA transfer from P. cf. bedriagae into P. lessonae, which was found in National Park «Smolny», Republic of Mordovia, Russia