Intelligent optical performance monitor using multi-task learning based artificial neural network

An intelligent optical performance monitor using multi-task learning based artificial neural network (MTL-ANN) is designed for simultaneous OSNR monitoring and modulation format identification (MFI). Signals' amplitude histograms (AHs) after constant module algorithm are selected as the input features for MTL-ANN. The experimental results of 20-Gbaud NRZ-OOK, PAM4 and PAM8 signals demonstrate that MTL-ANN could achieve OSNR monitoring and MFI simultaneously with higher accuracy and stability compared with single-task learning based ANNs (STL-ANNs). The results show an MFI accuracy of 100% and OSNR monitoring root-mean-square error of 0.63 dB for the three modulation formats under consideration. Furthermore, the number of neuron needed for the single MTL-ANN is almost the half of STL-ANN, which enables reduced-complexity optical performance monitoring devices for real-time performance monitoring

Integration of Physics-Derived Memristor Models with Machine Learning Frameworks

Simulation frameworks such MemTorch, DNN+NeuroSim, and aihwkit are commonly used to facilitate the end-to-end co-design of memristive machine learning (ML) accelerators. These simulators can take device nonidealities into account and are integrated with modern ML frameworks. However, memristors in these simulators are modeled with either lookup tables or simple analytic models with basic nonlinearities. These simple models are unable to capture certain performance-critical aspects of device nonidealities. For example, they ignore the physical cause of switching, which induces errors in switching timings and thus incorrect estimations of conductance states. This work aims at bringing physical dynamics into consideration to model nonidealities while being compatible with GPU accelerators. We focus on Valence Change Memory (VCM) cells, where the switching nonlinearity and SET/RESET asymmetry relate tightly with the thermal resistance, ion mobility, Schottky barrier height, parasitic resistance, and other effects. The resulting dynamics require solving an ODE that captures changes in oxygen vacancies. We modified a physics-derived SPICE-level VCM model, integrated it with the aihwkit simulator and tested the performance with the MNIST dataset. Results show that noise that disrupts the SET/RESET matching affects network performance the most. This work serves as a tool for evaluating how physical dynamics in memristive devices affect neural network accuracy and can be used to guide the development of future integrated devices.Comment: This work is published at the 2022 56th Asilomar Conferenc

Development and Validation of Targeted Next-Generation Sequencing Panels for Detection of Germline Variants in Inherited Diseases.

Context.-The number of targeted next-generation sequencing (NGS) panels for genetic diseases offered by clinical laboratories is rapidly increasing. Before an NGS-based test is implemented in a clinical laboratory, appropriate validation studies are needed to determine the performance characteristics of the test. Objective.-To provide examples of assay design and validation of targeted NGS gene panels for the detection of germline variants associated with inherited disorders. Data Sources.-The approaches used by 2 clinical laboratories for the development and validation of targeted NGS gene panels are described. Important design and validation considerations are examined. Conclusions.-Clinical laboratories must validate performance specifications of each test prior to implementation. Test design specifications and validation data are provided, outlining important steps in validation of targeted NGS panels by clinical diagnostic laboratories

Construction of Genetic Linkage Maps From a Hybrid Family of Large Yellow Croaker (Larimichthys crocea)

publishedVersio