176 research outputs found
Anisotropic Thermal Transport in Phase-Transition Layered 2D Alloys WSe2(1-x)Te2x
Transition metal dichalcogenide (TMD) alloys have attracted great interests
in recent years due to their tunable electronic properties, especially the
semiconductor-metal phase transition, along with their potential applications
in solid-state memories and thermoelectrics. However, the thermal conductivity
of layered two-dimensional (2D) TMD alloys remains largely unexplored despite
that it plays a critical role in the reliability and functionality of
TMD-enabled devices. In this work, we study the temperature-dependent
anisotropic thermal conductivity of the phase-transition 2D TMD alloys
WSe2(1-x)Te2x in both the in-plane direction (parallel to the basal planes) and
the cross-plane direction (along the c-axis) using time-domain
thermoreflectance measurements. In the WSe2(1-x)Te2x alloys, the cross-plane
thermal conductivity is observed to be dependent on the heating frequency
(modulation frequency of the pump laser) due to the non-equilibrium transport
between different phonon modes. Using a two-channel heat conduction model, we
extracted the anisotropic thermal conductivity at the equilibrium limit. A
clear discontinuity in both the cross-plane and the in-plane thermal
conductivity is observed as x increases from 0.4 to 0.6 due to the phase
transition from the 2H to Td phase in the layered 2D alloys. The temperature
dependence of thermal conductivity for the TMD alloys was found to become
weaker compared with the pristine 2H WSe2 and Td WTe2 due to the atomic
disorder. This work serves as an important starting point for exploring phonon
transport in layered 2D alloys
Blood neutrophil-lymphocyte ratio predicts survival for stages III-IV gastric cancer treated with neoadjuvant chemotherapy
A Matlab Toolbox for Feature Importance Ranking
More attention is being paid for feature importance ranking (FIR), in
particular when thousands of features can be extracted for intelligent
diagnosis and personalized medicine. A large number of FIR approaches have been
proposed, while few are integrated for comparison and real-life applications.
In this study, a matlab toolbox is presented and a total of 30 algorithms are
collected. Moreover, the toolbox is evaluated on a database of 163 ultrasound
images. To each breast mass lesion, 15 features are extracted. To figure out
the optimal subset of features for classification, all combinations of features
are tested and linear support vector machine is used for the malignancy
prediction of lesions annotated in ultrasound images. At last, the
effectiveness of FIR is analyzed according to performance comparison. The
toolbox is online (https://github.com/NicoYuCN/matFIR). In our future work,
more FIR methods, feature selection methods and machine learning classifiers
will be integrated
Discovery of Charge Order and Corresponding Edge State in Kagome Magnet FeGe
Kagome materials often host exotic quantum phases, including spin liquids, Chern gap, charge density wave, and superconductivity. Existing scanning microscopy studies of the kagome charge order have been limited to nonkagome surface layers. Here, we tunnel into the kagome lattice of FeGe to uncover features of the charge order. Our spectroscopic imaging identifies a 2×2 charge order in the magnetic kagome lattice, resembling that discovered in kagome superconductors. Spin mapping across steps of unit cell height demonstrates the existence of spin-polarized electrons with an antiferromagnetic stacking order. We further uncover the correlation between antiferromagnetism and charge order anisotropy, highlighting the unusual magnetic coupling of the charge order. Finally, we detect a pronounced edge state within the charge order energy gap, which is robust against the irregular shape fluctuations of the kagome lattice edges. We discuss our results with the theoretically considered topological features of the kagome charge order including unconventional magnetism and bulk-boundary correspondence
Clinical characteristics of two patients with neuronal intranuclear inclusion disease and literature review
BackgroundNeuronal intranuclear inclusion disease (NIID) is a rare chronic progressive neurodegenerative disease, with complex and diverse clinical manifestations and pathological eosinophilic hyaline intranuclear inclusions in the central and peripheral nervous systems and visceral organs. Improvements in diagnostic methods such as skin biopsy and gene testing are helpful in revealing the clinical and genetic characters of NIID.Materials and methodsWe presented two cases of NIID diagnosed by using NOTCH2NLC gene testing and skin biopsy. Diffusion weighted imaging (DWI) showed high linear intensity in corticomedullary junction. We also reviewed all the published NIID cases with positive NOTCH2NLC GGC repeat expansion and skin biopsy results in PubMed.ResultsPatient 1 was a 63-year-old male who carried 148 GGC repeats and presented with progressive tremor and limb weakness. Patient 2 was a 62-year-old woman who carried 131 GGC repeats and presented with tremors, memory loss and headaches. The most common clinical manifestation of 63 NIID patients in this study was cognitive impairment, followed by tremors. In our study, almost all the patients were from East Asia, the male to female ratio was 1:1.26, with an age of onset of 54.12 ± 14.12 years, and an age of diagnosis of 60.03 ± 12.21 years. Symmetrical high signal intensity at the corticomedullary junction on DWI were revealed in 80.96% of the patients. For the GGC repeat numbers, the majority of GGC repeats were in the 80–119 intervals, with few GGC repeats above 160. The number of GGC repetitions was significantly higher in patients presented with muscle weakness than in other clinical manifestations.ConclusionNIID is a neurodegenerative disease caused by aberrant polyglycine (polyG) protein aggregation. NIID mostly occurs in the elderly population in East Asia, with cognitive dysfunction as the most common symptom. Staging NIID based on clinical presentation is inappropriate because most patients with NIID have overlapping symptoms. In our study, there was no significant correlation between the number of GGC repeats and different phenotypes except for muscle weakness. Abnormal trinucleotides repeat and PolyG protein aggregation maybe common pathogenic mechanism in neurodegenerative diseases and cerebrovascular diseases, which needs to be confirmed by more studies
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C. elegans SIRT6/7 Homolog SIR-2.4 Promotes DAF-16 Relocalization and Function during Stress
FoxO transcription factors and sirtuin family deacetylases regulate diverse biological processes, including stress responses and longevity. Here we show that the Caenorhabditis elegans sirtuin SIR-2.4—homolog of mammalian SIRT6 and SIRT7 proteins—promotes DAF-16–dependent transcription and stress-induced DAF-16 nuclear localization. SIR-2.4 is required for resistance to multiple stressors: heat shock, oxidative insult, and proteotoxicity. By contrast, SIR-2.4 is largely dispensable for DAF-16 nuclear localization and function in response to reduced insulin/IGF-1-like signaling. Although acetylation is known to regulate localization and activity of mammalian FoxO proteins, this modification has not been previously described on DAF-16. We find that DAF-16 is hyperacetylated in sir-2.4 mutants. Conversely, DAF-16 is acetylated by the acetyltransferase CBP-1, and DAF-16 is hypoacetylated and constitutively nuclear in response to cbp-1 inhibition. Surprisingly, a SIR-2.4 catalytic mutant efficiently rescues the DAF-16 localization defect in sir-2.4 null animals. Acetylation of DAF-16 by CBP-1 in vitro is inhibited by either wild-type or mutant SIR-2.4, suggesting that SIR-2.4 regulates DAF-16 acetylation indirectly, by preventing CBP-1-mediated acetylation under stress conditions. Taken together, our results identify SIR-2.4 as a critical regulator of DAF-16 specifically in the context of stress responses. Furthermore, they reveal a novel role for acetylation, modulated by the antagonistic activities of CBP-1 and SIR-2.4, in modulating DAF-16 localization and function
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