An Evaluation Method of Comprehensive Product Quality for Customer Satisfaction Based on Intuitionistic Fuzzy Number

How to maximize customer satisfaction is an important research topic in the service quality evaluation. This paper proposes an evaluation method of comprehensive product quality for customer satisfaction based on the intuitionistic fuzzy number. In this method, we design a questionnaire and investigate the customer’s language evaluation information of product quality evaluation, including product expectations and product perception at first. And then, the product quality evaluation model is obtained by Delphi method; that is, the first-level evaluation indexes and the second-level evaluation indexes are obtained and the weight vector of each evaluation index is determined. Next, language evaluation information translates into corresponding fuzzy numbers using intuitionistic fuzzy numbers. Therefore, the results of the product quality evaluation of the production system are obtained using the weighted mean method. Finally, an example is used to illustrate the feasibility and effectiveness of the proposed method

(5S*,6R*,7R*)-6-Formyl-5-phenyl-7-propyl­perhydro­pyrazolo[1,2-a]pyrazol-1-one

The title compound, C16H20N2O2, was obtained by catalytic asymmetric cyclo­addition of trans-3-propyl­acrolein with 1-benzyl­idenepyrazolid-3-one betaine. There are two symmetry-independent mol­ecules in the asymmetric unit. In both mol­ecules, the two five-membered heterocyclic rings adopt envelope conformations

Construction and validation of a novel prognostic model for intrahepatic cholangiocarcinoma based on a combined scoring system of systemic immune-inflammation index and albumin-bilirubin: a multicenter study

BackgroundThe degree of inflammation and immune status is widely recognized to be associated with intrahepatic cholangiocarcinoma (ICC) and is closely linked to poor postoperative survival. The purpose of this study was to evaluate whether the systemic immune-inflammatory index (SII) and the albumin bilirubin (ALBI) grade together exhibit better predictive strength compared to SII and ALBI separately in patients with ICC undergoing curative surgical resection.MethodsA retrospective analysis was performed on a cohort of 374 patients with histologically confirmed ICC who underwent curative surgical resection from January 2016 to January 2020 at three medical centers. The cohort was divided into a training set comprising 258 patients and a validation set consisting of 116 patients. Subsequently, the prognostic predictive abilities of three indicators, namely SII, ALBI, and SII+ALBI grade, were evaluated. Independent risk factors were identified through univariate and multivariate analyses. The identified independent risk factors were then utilized to construct a nomogram prediction model, and the predictive strength of the nomogram prediction model was assessed through Receiver Operating Characteristic (ROC) survival curves and calibration curves.ResultsUnivariate analysis of the training set, consisting of 258 eligible patients with ICC, revealed that SII, ALBI, and SII+ALBI grade were significant prognostic factors for overall survival (OS) and recurrence-free survival (RFS) (p < 0.05). Multivariate analysis revealed the independent significance of SII+ALBI grade as a risk factor for postoperative OS and RFS (p < 0.05). Furthermore, we conducted an analysis of the correlation between SII, ALBI, SII+ALBI grade, and clinical features, indicating that SII+ALBI grade exhibited stronger associations with clinical and pathological characteristics compared to SII and ALBI. We constructed a predictive model for postoperative survival in ICC based on SII+ALBI grade, as determined by the results of multivariate analysis. Evaluation of the model’s predictive strength was performed through ROC survival curves and calibration curves in the training set and validation set, revealing favorable predictive performance.ConclusionThe SII+ALBI grade, a novel classification based on inflammatory and immune status, serves as a reliable prognostic indicator for postoperative OS and RFS in patients with ICC

Seeking celestial Positronium with an OH-suppressed diffraction-limited spectrograph

Celestially, Positronium (Ps), has only been observed through gamma-ray emission produced by its annihilation. However, in its triplet state, a Ps atom has a mean lifetime long enough for electronic transitions to occur between quantum states. This produces a recombination spectrum observable in principle at near IR wavelengths, where angular resolution greatly exceeding that of the gamma-ray observations is possible. However, the background in the NIR is dominated by extremely bright atmospheric hydroxyl (OH) emission lines. In this paper we present the design of a diffraction-limited spectroscopic system using novel photonic components - a photonic lantern, OH Fiber Bragg Grating filters, and a photonic TIGER 2-dimensional pseudo-slit - to observe the Ps Balmer alpha line at 1.3122 microns for the first time.Comment: 6 pages, 9 Figures, 2 Tables. Accepted to Applied Optics feature issue on Astrophotonic

Research on oil-based plugging technology in a horizontal well section of the Fuling shale gas field

To address the serious issues of leakage, challenging plugging, and significant friction related to the long horizontal section construction in the Fuling shale gas field, a study was conducted to develop a suitable leak-proof agent OBMCP for oil-based drilling fluid. The difficulties of preventing leakage and plugging oil-based drilling fluid were analyzed, and the amount of reactively consolidated polymer HY-1 was controlled at 6.25 – 7.5% while considering the plugging strength requirements and plugging costs. The enhancer ZQJ was controlled at 0.4 – 0.6% to achieve high-strength rapid plugging, and the gelation time was controlled under the premise of safe construction to achieve a controllable curing time. Consequently, the oil-based drilling fluid leakage prevention and plugging technology were formed and applied in the J1 and J2 wells. The field test showed that the optimized drilling fluid had stable performance, a good plugging effect from the consolidation plugging agent, a stable borehole wall, small leakage, and strong anti-pollution ability, thereby achieving high-strength rapid plugging and a controllable curing time

A workflow for turbidite reservoir characterization—a case study of the Macedon member, Northern Carnarvon Basin, NW Australia

Deep-water turbidite systems on passive continental margins are of interest for oil and gas exploration. However, their complexity poses challenges for reservoir characterization. In this study, we proposed a reservoir characterization workflow for the Macedon member turbidite, employing a combination of 90° phase adjustment, geobody extraction, and genetic inversion, based on the abundant well logging and seismic data from the Enfield field, Northern Carnarvon Basin. Our workflow involved seismic sedimentology to determine the morphology of sand bodies and inversion to determine the net reservoir range, resulting in 3D geological attribute modeling. We applied a 90° phase adjustment correlated seismic events and well logging responses. By stratal slice interpretation and geological body extraction, it was revealed the turbidite reservoir distribution. Finally, we achieved net reservoir characterization of the Macedon member through genetic inversion porosity and geostatistical methods. The results showed that the Macedon turbidite reservoir can be divided into the top and base reservoirs. The top reservoir is sheet-like, and the base reservoir is channelized. The average porosity of the former was 24%, while the average porosity of the later is 20%. The top reservoir has better reservoir quality. Furthermore, we discussed sea level changes affect turbidite distribution and reservoir quality. During the Falling Stage Systems Tract (FSST), the long transportation distance led to relatively less sediment supply and a low sand/mud ratio, resulting in confined, channelized, poor quality turbidite reservoir. In contrast, during the Lowstand Systems Tract (LST), unconfined, amalgamated, good quality turbidite sheet reservoirs were formed. The improved workflow based on seismic sedimentology presented in this article proves effective in characterizing complex reservoirs and contributes to the simplified and efficient management of reservoirs

Comparison of genetic impact on growth and wood traits between seedlings and clones from the same plus trees of Pinus koraiensis

To evaluate the relationships among clones and open pollinated families from the same plus trees and to select elite breeding materials, growth, and wood characteristics of 33-year-old Pinus koraiensis clones and families were measured and analyzed. The results show that growth and wood characters varied significantly. The variation due to clonal effects was higher than that of family effects. The ratio of genetic to phenotypic coefficient of variation of clones in growth and wood traits was above 90%, and the repeatability of these characteristics was more than 0.8, whereas the ratio of genetic to phenotypic coefficient of variation of families was above 90%. The broad-sense heritability of all characteristics exceeded 0.4, and the narrow-sense family heritability of growth traits was less than 0.3. Growth characteristics were positively correlated with each other, but most wood properties were weakly correlated in both clones and families. Fiber length and width were positively correlated between clones and families. Using the membership function method, eleven clones and four families were selected as superior material for improved diameter growth and wood production, and two families from clonal and open-pollinated trees showed consistently better performance. Generally, selection of the best clones is an effective alternative to deployment of families as the repeatability estimates from clonal trees were higher than narrow-sense heritability estimates from open pollinated families. The results provide valuable insight for improving P. koraiensis breeding programs and subsequent genetic improvement

Soybean Breeding on Seed Composition Trait

Soybean is a most important crop providing edible oil and plant protein source for human beings, in addition to animal feed because of high protein and oil content. This review summarized the progresses in the QTL mapping, candidate gene cloning and functional analysis and also the regulation of soybean oil and seed storage protein accumulation. Furthermore, as soybean genome has been sequenced and released, prospects of multiple omics and advanced biotechnology should be combined and applied for further refine research and high-quality breeding

Dysfunction of the noradrenergic system drives inflammation, α-synucleinopathy, and neuronal loss in mouse colon

Clinical and pathological evidence revealed that α-synuclein (α-syn) pathology seen in PD patients starts in the gut and spreads via anatomically connected structures from the gut to the brain. Our previous study demonstrated that depletion of central norepinephrine (NE) disrupted brain immune homeostasis, producing a spatiotemporal order of neurodegeneration in the mouse brain. The purpose of this study was 1) to determine the role of peripheral noradrenergic system in the maintenance of gut immune homeostasis and in the pathogenesis of PD and 2) to investigate whether NE-depletion induced PD-like α-syn pathological changes starts from the gut. For these purposes, we investigated time-dependent changes of α-synucleinopathy and neuronal loss in the gut following a single injection of DSP-4 (a selective noradrenergic neurotoxin) to A53T-SNCA (human mutant α-syn) over-expression mice. We found DPS-4 significantly reduced the tissue level of NE and increased immune activities in gut, characterized by increased number of phagocytes and proinflammatory gene expression. Furthermore, a rapid-onset of α-syn pathology was observed in enteric neurons after 2 weeks and delayed dopaminergic neurodegeneration in the substantia nigra was detected after 3-5 months, associated with the appearance of constipation and impaired motor function, respectively. The increased α-syn pathology was only observed in large, but not in the small, intestine, which is similar to what was observed in PD patients. Mechanistic studies reveal that DSP-4-elicited upregulation of NADPH oxidase (NOX2) initially occurred only in immune cells during the acute intestinal inflammation stage, and then spread to enteric neurons and mucosal epithelial cells during the chronic inflammation stage. The upregulation of neuronal NOX2 correlated well with the extent of α-syn aggregation and subsequent enteric neuronal loss, suggesting that NOX2-generated reactive oxygen species play a key role in α-synucleinopathy. Moreover, inhibiting NOX2 by diphenyleneiodonium or restoring NE function by salmeterol (a β2-receptor agonist) significantly attenuated colon inflammation, α-syn aggregation/propagation, and enteric neurodegeneration in the colon and ameliorated subsequent behavioral deficits. Taken together, our model of PD shows a progressive pattern of pathological changes from the gut to the brain and suggests a potential role of the noradrenergic dysfunction in the pathogenesis of PD

Physiological concentration of protocatechuic acid directly protects vascular endothelial function against inflammation in diabetes through Akt/eNOS pathway

BackgroundCardiovascular diseases (CVDs) have been the major cause of mortality in type 2 diabetes. However, new approaches are still warranted since current diabetic medications, which focus mainly on glycemic control, do not effectively lower cardiovascular mortality rate in diabetic patients. Protocatechuic acid (PCA) is a phenolic acid widely distributed in garlic, onion, cauliflower and other plant-based foods. Given the anti-oxidative effects of PCA in vitro, we hypothesized that PCA would also have direct beneficial effects on endothelial function in addition to the systemic effects on vascular health demonstrated by previous studies.Methods and resultsSince IL-1β is the major pathological contributor to endothelial dysfunction in diabetes, the anti-inflammatory effects of PCA specific on endothelial cells were further verified by the use of IL-1β-induced inflammation model. Direct incubation of db/db mouse aortas with physiological concentration of PCA significantly ameliorated endothelium-dependent relaxation impairment, as well as reactive oxygen species overproduction mediated by diabetes. In addition to the well-studied anti-oxidative activity, PCA demonstrated strong anti-inflammatory effects by suppressing the pro-inflammatory cytokines MCP1, VCAM1 and ICAM1, as well as increasing the phosphorylation of eNOS and Akt in the inflammatory endothelial cell model induced by the key player in diabetic endothelial dysfunction IL-1β. Upon blocking of Akt phosphorylation, p-eNOS/eNOS remained low and the inhibition of pro-inflammatory cytokines by PCA ceased.ConclusionPCA exerts protection on vascular endothelial function against inflammation through Akt/eNOS pathway, suggesting daily acquisition of PCA may be encouraged for diabetic patients