353 research outputs found
Direct and Indirect Use of Information Systems in Organizations: An Empirical Investigation of System Usage in a Public Hospital
A user’s interaction with an Information System (IS) could transpire in two ways: direct and indirect. While most prior literature examines the direct interaction between a user and the system, few have examined and differentiated between direct and indirect use. In this study, we anchor on the theory of psychological attachment to study the effects of various external social factors on direct-usage and indirect-usage of an organizational IS. Survey results from 102 physicians in a public hospital reveal that punishment and informational influence are significantly related to direct-usage of the Electronic Medical Record System (EMRS) by physicians. Punishment and image are significantly associated with indirect-usage of EMRS
Acetohydroxamic acid adsorbed at copper surface: electrochemical, Raman and theoretical observations
Eos Negatively Regulates Human γ-globin Gene Transcription during Erythroid Differentiation
BACKGROUND: Human globin gene expression is precisely regulated by a complicated network of transcription factors and chromatin modifying activities during development and erythropoiesis. Eos (Ikaros family zinc finger 4, IKZF4), a member of the zinc finger transcription factor Ikaros family, plays a pivotal role as a repressor of gene expression. The aim of this study was to examine the role of Eos in globin gene regulation. METHODOLOGY/PRINCIPAL FINDINGS: Western blot and quantitative real-time PCR detected a gradual decrease in Eos expression during erythroid differentiation of hemin-induced K562 cells and Epo-induced CD34+ hematopoietic stem/progenitor cells (HPCs). DNA transfection and lentivirus-mediated gene transfer demonstrated that the enforced expression of Eos significantly represses the expression of γ-globin, but not other globin genes, in K562 cells and CD34+ HPCs. Consistent with a direct role of Eos in globin gene regulation, chromatin immunoprecipitaion and dual-luciferase reporter assays identified three discrete sites located in the DNase I hypersensitivity site 3 (HS3) of the β-globin locus control region (LCR), the promoter regions of the Gγ- and Aγ- globin genes, as functional binding sites of Eos protein. A chromosome conformation capture (3C) assay indicated that Eos may repress the interaction between the LCR and the γ-globin gene promoter. In addition, erythroid differentiation was inhibited by enforced expression of Eos in K562 cells and CD34+ HPCs. CONCLUSIONS/SIGNIFICANCE: Our results demonstrate that Eos plays an important role in the transcriptional regulation of the γ-globin gene during erythroid differentiation
Storage of multiple single-photon pulses emitted from a quantum dot in a solid-state quantum memory
Quantum repeaters are critical components for distributing entanglement over
long distances in presence of unavoidable optical losses during transmission.
Stimulated by Duan-Lukin-Cirac-Zoller protocol, many improved quantum-repeater
protocols based on quantum memories have been proposed, which commonly focus on
the entanglement-distribution rate. Among these protocols, the elimination of
multi-photons (multi-photon-pairs) and the use of multimode quantum memory are
demonstrated to have the ability to greatly improve the
entanglement-distribution rate. Here, we demonstrate the storage of
deterministic single photons emitted from a quantum dot in a
polarization-maintaining solid-state quantum memory; in addition,
multi-temporal-mode memory with , and narrow single-photon pulses
is also demonstrated. Multi-photons are eliminated, and only one photon at most
is contained in each pulse. Moreover, the solid-state properties of both
sub-systems make this configuration more stable and easier to be scalable. Our
work will be helpful in the construction of efficient quantum repeaters based
on all-solid-state devicesComment: Published version, including supplementary materia
- …