Di-μ-aqua-bis­{diaqua­[μ-4-({4-[bis­(2-hy­droxy­eth­yl)amino]-6-chloro-1,3,5-triazin-2-yl}amino)­benzene­sulfonato]­sodium(I)}

In the dinuclear title compound, [Na2(C13H15ClN5O5S)2(H2O)6]n, two Na+ cations, disposed about a centre of inversion, are linked by two bridging water mol­ecules. The coordination geometry is based on an O5 donor set defined by four water mol­ecules and a 4-amino­benzene­sulfonate O atom in a distorted trigonal–bipyramidal geometry. In the crystal, significant O—H⋯O, O—H⋯N and N—H⋯O hydrogen bonds lead to the formation of a three-dimensional architecture

Searching for a0(980)a_0(980)-meson parton distribution function

In this paper, we calculate the scalar $a_0(980)$-meson leading-twist wavefunction by using light-cone harmonic oscillator model (LCHO). In which the model parameters are determined by fitting the $\xi$-moments $\langle\xi_{a_0}^n\rangle_\zeta$ of its light-cone distribution amplitudes. Then, the $a_0(980)$-meson leading-twist light-cone distribution amplitudes with three different scales $\zeta= (1.0, 2.0, 5.2)~{\rm GeV}$ are given. After constructing the relationship between $a_0(980)$-meson leading-twist parton distribution functions/valence quark distribution function and its LCHO wavefunction, we exhibit the $q^{a_0}(x,\zeta)$ and $x q^{a_0}(x,\zeta)$ with different scales. Furthermore, we also calculate the Mellin moments of the $a_0(980)$-meson's valence quark distribution function $\langle x^n q^{a_0}\rangle_\zeta$ with $n = (1,2,3)$, i.e. $\langle x q^{a_0}\rangle_{\zeta_5} = 0.026$, $\langle x^2 q^{a_0}\rangle_{\zeta_5} = 0.017$ and $\langle x^3 q^{a_0}\rangle_{\zeta_5} = 0.012$. Finally, the scale evolution for the ratio of the Mellin moments $x^n_{a_0}(\zeta,\zeta_k)$ are presented.Comment: 7 pages, 3 figures, comments welcom

Semi-leptonic form factors of Ξc→Ξ\Xi_{c}\to\Xi in QCD sum rules

There exists a significant deviation between the most recent Lattice QCD simulation and experimental measurement by Belle for $\Xi_{c}^{0}\to\Xi^{-}\ell^{+}\nu_{\ell}$. In this work, we investigate the $\Xi_{c}\to\Xi$ form factors in QCD sum rules. To this end, the two-point correlation functions of $\Xi_{c}$ and $\Xi$, and the three-point correlation functions of $\Xi_{c}\to\Xi$ are calculated. At the QCD level, contributions from up to dimension-6 four-quark operators are considered, and the leading order results of the Wilson coefficients are obtained. For the form factors, relatively stable Borel windows can be found. Our form factors are comparable with those of Lattice QCD, except for $f_{\perp}$. The obtained form factors are then used to predict the branching ratios of $\Xi_{c}\to\Xi \ell^{+}\nu_{\ell}$, and our predictions are consistent with the most recent data of ALICE and Belle, and those of Lattice QCD within error. Given that the branching ratios only contain limited information, we suggest the experimentalists directly measure the form factors of $\Xi_{c}\to\Xi$.Comment: 18 pages, 7 figures; version accepted by PR

Apoptosis Induction in Primary Human Colorectal Cancer Cell Lines and Retarded Tumor Growth in SCID Mice by Sulforaphane

We have investigated the anticancer effects of the dietary isothiocyanate sulforaphane (SFN) on colorectal cancer (CRC), using primary cancer cells lines isolated from five Taiwanese colorectal cancer patients as the model for colorectal cancer. SFN-treated cells accumulated in metaphase (SFN 6.25 μM) and subG1 (SFN 12.5 and 25 μM) as determined by flow cytometry. In addition, treated cells showed nuclear apoptotic morphology that coincided with an activation of caspase-3, and loss of mitochondrial membrane potential (ΔΨm). Incubations at higher SFN doses (12.5 and 25 μM) resulted in cleavage of procaspase-3 and elevated caspase-2, -3, -8, and -9 activity, suggesting that the induction of apoptosis and the sulforaphane-induced mitosis delay at the lower dose are independently regulated. Daily SFN s.c. injections (400 micromol/kg/d for 3 weeks) in severe combined immunodeficient mice with primary human CRC (CP1 to CP5) s.c. tumors resulted in a decrease of mean tumor weight by 70% compared with vehicle-treated controls. Our findings suggest that, in addition to the known effects on cancer prevention, sulforaphane may have antitumor activity in established colorectal cancer

Clinical efficacy and safety of edaravone therapy in acute cerebral haemorrhage

Purpose: To evaluate the clinical efficacy and safety of edaravone in the treatment of acute cerebral haemorrhage (ACH).Methods: This study recruited 120 patients who developed ACH. The patients were divided into control and treatment groups with 60 patients per group. The control group underwent conventional treatment and the treatment group also received intravenous edaravone. The volumes of cerebral edema and cerebral hematoma, high-sensitivity C-reactive protein (hs-CRP) and interleukin-6 (IL-6) levels, and Chinese Stroke Scale (CSS) score before and after treatment were compared between the two groups.Results: The respective cerebral edema volumes of the control and treatment groups decreased from 20.99 ± 12.09 and 21.80 ± 12.01 mL on day 0 to 11.23 ± 6.34 and 12.11 ± 5.98 mL at day 7 and 4.69 ± 4.03 and 4.64 ± 3.9 mL on day 14 (P < 0.05). The respective cerebral hematoma volumes of the control and treatment groups decreased from 18.98 ± 12.04 and 18.97 ± 12.07 mL on day 0 to 12.34 ± 6.57 and 11.89 ± 4.01 mL at day 7 and 9.49 ± 3.95 and 9.52 ± 3.96 mL on day 14. Compared with pretreatment, hs-CRP and IL-6 levels and CSS score of the two groups decreased significantly following treatment (p < 0.05); the differences in the cerebral edema and hematoma volumes of the two groups on days 7 and 14 were not significant (p > 0.05). The hs-CRP and IL-6 levels and CSS scores of the treatment group decreased appreciably (p < 0.05), while the incidence of adverse reactions in the treatment and control groups was 16.67 and 13.33 %, respectively, but the difference was not significant (p > 0.05).Conclusion: Edaravone shows remarkable clinical efficacy and safety with no obvious adverse reactions in the treatment of ACH. Therefore, its use is recommended.Keywords: Cerebral haemorrhage, Edaravone, Cerebral edema, C-reactive protein, Interleukin-6, Chinese Stroke Scal

4-(3-Carb­oxy­phen­yl)pyridinium nitrate

In the title salt, C12H10NO2 +·NO3 −, the dihedral angle between the pyridine ring and the benzene ring of the 4-(3-carb­oxy­phen­yl)pyridinium cation is 30.14 (2)°. Inversion-related pairs of cations are linked into dimers by pairs of O—H⋯O hydrogen bonds. Pairs of dimers are linked by N—H⋯O and C—H⋯O hydrogen bonds involving nitrate anions as acceptors, generating supra­molecular chains along the diagonal of the bc plane