Primary renal teratoma: a rare entity

ABSTRACT: Teratomas are neoplasms that arise from pluripotent cells and can differentiate along one or more embryonic germ lines. Renal teratoma is an exceedingly rare condition. Teratomas commonly arise in the gonads, sacrococcygeal region, pineal gland, and retroperitoneum. They present mainly as an abdominal mass with few other symptoms. Majority of the tumors are benign, situated on the left side and para renal, occasional lesions are bilateral. If diagnosed early, they are amenable to curative excision. Renal teratomas are rare and most have been dismissed as cases of teratoid nephroblastomas or retroperitoneal teratomas secondarily invading the kidney. The differentiation between these two neoplasms in the kidney is often problematic. We present a case of intrarenal immature teratoma in a six-month-old baby girl. VIRTUAL SLIDES: The virtual slides for this article can be found here: http://www.diagnosticpathology.diagnomx.eu/vs/1746249869599954

Hamartome lipomateux superficiel de Hoffmann-Zurhelle

L'hamartome lipomateux superficiel de Hoffmann-Zurhelle est une tumeur bénigne souvent congénitale. Histologiquement, il est caractérisé par la présence hétérotopique de cellules adipeuses quelquefois lipoblastiques autour des trajets vasculaires dermiques. Nous rapportons une nouvelle observation de forme multiple à révélation tardive chez une femme âgée de 31 ans sans antécédents pathologiques notables qui a été adressée à la consultation pour des papules et tumeurs asymptomatiques de couleur chaire se regroupent en placards à disposition linéaire et zostèriforme au niveau de la face externe de la cuisse droite depuis l'âge de 13 ans, augmentant progressivement de taille. L'étude histologique d'un fragment biopsique avait montré un épiderme régulier, plicaturé et kératinisant, soulevé par un tissu fibro-adipeux abondant incluant quelques vaisseaux sanguins aux dépens du derme moyen. Ces données cliniques et histologiques ont permis de retenir le diagnostic d'hamartome lipomateux superficiel. Une exérèse chirurgicale des tumeurs de grande taille a été proposée complété par le laser CO2 pour le reste de lésions cutanées. L'hamartome lipomateux superficiel est une lésion bénigne sans potentiel de malignité. L'exérèse chirurgicale peut être proposée si la lésion est gênante ou dans un but essentiellement esthétique.Keywords: Hamartome lipomateux, Hoffmann-Zurhelle, tumeur bénign

Can p63 serve as a biomarker for giant cell tumor of bone? A Moroccan experience

<p>Abstract</p> <p>Background</p> <p>Multinucleated giant cell-containing tumors and pseudotumors of bone represent a heterogeneous group of benign and malignant lesions. Differential diagnosis can be challenging, particularly in instances of limited sampling. The purpose of this study was to evaluate the contribution of the P63 in the positive and differential diagnosis of giant cell tumor of bone.</p> <p>Methods</p> <p>This study includes 48 giant cell-containing tumors and pseudotumors of bone. P63 expression was evaluated by immunohistochemistry. Data analysis was performed using Epi-info software and SPSS software package (version 17).</p> <p>Results</p> <p>Immunohistochemical analysis showed a P63 nuclear expression in all giant cell tumors of bone, in 50% of osteoid osteomas, 40% of aneurysmal bone cysts, 37.5% of osteoblastomas, 33.3% of chondromyxoide fibromas, 25% of non ossifiant fibromas and 8.3% of osteosarcomas. Only one case of chondroblastoma was included in this series and expressed p63. No P63 immunoreactivity was detected in any of the cases of central giant cell granulomas or langerhans cells histiocytosis. The sensitivity and negative predictive value (NPV) of P63 immunohistochemistry for the diagnosis of giant cell tumor of bone were 100%. The specificity and positive predictive value (PPV) were 74.42% and 59.26% respectively.</p> <p>Conclusions</p> <p>This study found not only that GCTOB expresses the P63 but it also shows that this protein may serve as a biomarker for the differential diagnosis between two morphologically similar lesions particularly in instances of limited sampling. Indeed, P63 expression seems to differentiate between giant cell tumor of bone and central giant cell granuloma since the latter does not express P63. Other benign and malignant giant cell-containing lesions express P63, decreasing its specificity as a diagnostic marker, but a strong staining was seen, except a case of chondroblastoma, only in giant cell tumor of bone. Clinical and radiological confrontation remains essential for an accurate diagnosis.</p> <p>Virtual slides</p> <p>The virtual slide(s) for this article can be found here: <url>http://www.diagnosticpathology.diagnomx.eu/vs/1838562590777252</url>.</p