Virchow: A Million-Slide Digital Pathology Foundation Model

Computational pathology uses artificial intelligence to enable precision medicine and decision support systems through the analysis of whole slide images. It has the potential to revolutionize the diagnosis and treatment of cancer. However, a major challenge to this objective is that for many specific computational pathology tasks the amount of data is inadequate for development. To address this challenge, we created Virchow, a 632 million parameter deep neural network foundation model for computational pathology. Using self-supervised learning, Virchow is trained on 1.5 million hematoxylin and eosin stained whole slide images from diverse tissue groups, which is orders of magnitude more data than previous works. When evaluated on downstream tasks including tile-level pan-cancer detection and subtyping and slide-level biomarker prediction, Virchow outperforms state-of-the-art systems both on internal datasets drawn from the same population as the pretraining data as well as external public datasets. Virchow achieves 93% balanced accuracy for pancancer tile classification, and AUCs of 0.983 for colon microsatellite instability status prediction and 0.967 for breast CDH1 status prediction. The gains in performance highlight the importance of pretraining on massive pathology image datasets, suggesting pretraining on even larger datasets could continue improving performance for many high-impact applications where limited amounts of training data are available, such as drug outcome prediction

A Novel Feature Extraction Method for the Condition Monitoring of Bearings

International audienceThis paper presents an innovative approach to the extraction of an indicator for the monitoring of bearing degradation. This approach is based on the principles of the empirical mode decomposition (EMD) and the Hilbert transform (HT). The proposed approach extracts the temporal components of oscillating vibration signals called intrinsic mode functions (IMFs). These components are classified locally from the highest frequencies to the lowest frequencies. By selecting the appropriate components, it is possible to construct a bank of self-adaptive and automatic filters. Combined with the HT, the EMD allows an estimate of the instantaneous frequency of each IMF. A health indicator called the Hilbert marginal spectrum density is then extracted in order to detect and diagnose the degradation of bearings. This approach was validated on two test benches with variable speeds and loads. The obtained results demonstrated the effectiveness of this approach for the monitoring of ball and roller bearings