COMPARATIVE STUDY OF EFFECT OF CHAIN YOGIC EXERCISE (YOGASANA) AND YOGIC THERAPY (AGNISAR KRIYA) FOR REHABILITATION OF TYPE 2 DIABETES MELLITUS (T2D)

The motive of this study was to find out the effect of Chain Yogic Exercise (Yogasana), Yogic Therapy (Agnisar Kriya) on Diabetes Mellitus (T2D). For the purpose of this study 200 subjects were selected and divided into two groups from Delhi, India. Both groups are experimental groups. In each group, 100:100 Type 2 Diabetes Mellitus (T2DM) subjects were distributed. There were 50 females and 50 males in each group i.e. half of the each group was female. The subjects’ age ranged between 35-45 years. One group was engaged in Chain Yogic Exercise (Yogasana) and the other group was perform Yogic Therapy (Agnisar Kriya), This process was for 90 days (30-30-30 days). The data was collected on the first day (dated 16th September 2020) of 1st round as pre-test and on the last day (dated 16th October 2020) of 1st round as post-test. For statistical analysis and interpretation of data, paired t-Test was employed. The level of significance had been taken 0.05 and 0.01. The study found Chain Yogic Exercise (Yogasana), Yogic Therapy (Agnisar Kriya) both has a significant effect to control Diabetes Mellitus (T2D). The study also found that Yogic Therapy (Agnisar Kriya) had much better effect to control Diabetes Mellitus (T2D) than Chain Yogic Exercise (Yogasana). Article visualizations

A SURVEY ON OPPORTUNITY, SCOPE AND POSSIBILITIES OF YOGA INTERVENTION IN MODERN CHINA

The purpose of this study was to find out the scope, facilities and possibilities of Yoga intervention in China. For the purpose of this study, 201 samples i.e. yoga instructors (22); yoga studio owners (7); yoga instructors plus yoga studio owners (8) yoga practitioners (113) yoga lovers (50) and others (1) from various provinces and cities from China were randomly selected. The subjects’ age ranged between 60+ to 90+ years. To find out the scope, facilities and possibilities of Yoga intervention in China, a questionnaire made by “Vivekananda Cultural Communication (Shanghai) Co. Ltd.” based on “Daily Yoga Courses and Training Content in China” were introduced. For statistical analysis and interpretation of data, descriptive statistics of selected variables and descriptive statement analysis method were conducted. Interestingly this study found a very high level of scope, facilities and realistic possibilities of Yoga intervention in China which directly or indirectly might be help to develop yoga industries in China and also can better understand the need and interest of yoga for health and wellbeing among Chines population in new era.   Article visualizations

3,4-Bis(4-meth­oxy­phen­yl)-2,5-dihydro-1H-pyrrole-2,5-dione

In the title compound, C18H15NO4, the benzene rings form quite different dihedral angles [16.07 (1) and 59.50 (1)°] with the central pyrrole ring, indicating a twisted mol­ecule. Conjugation is indicated between the five- and six-membered rings by the lengths of the C—C bonds which link them [1.462 (3) and 1.477 (3) Å]. The most prominent feature of the crystal packing is the formation of inversion dimers via eight-membered {⋯HNCO}2 synthons

CQNV: A combination of coarsely quantized bitstream and neural vocoder for low rate speech coding

Recently, speech codecs based on neural networks have proven to perform better than traditional methods. However, redundancy in traditional parameter quantization is visible within the codec architecture of combining the traditional codec with the neural vocoder. In this paper, we propose a novel framework named CQNV, which combines the coarsely quantized parameters of a traditional parametric codec to reduce the bitrate with a neural vocoder to improve the quality of the decoded speech. Furthermore, we introduce a parameters processing module into the neural vocoder to enhance the application of the bitstream of traditional speech coding parameters to the neural vocoder, further improving the reconstructed speech's quality. In the experiments, both subjective and objective evaluations demonstrate the effectiveness of the proposed CQNV framework. Specifically, our proposed method can achieve higher quality reconstructed speech at 1.1 kbps than Lyra and Encodec at 3 kbps.Comment: Accepted by INTERSPEECH 202

Discovery of novel inhibitors of Streptococcus pneumoniae based on the virtual screening with the homology-modeled structure of histidine kinase (VicK)

<p>Abstract</p> <p>Background</p> <p>Due to the widespread abusage of antibiotics, antibiotic-resistance in <it>Streptococcus pneumoniae </it>(<it>S. pneumoniae</it>) has been increasing quickly in recent years, and it is obviously urgent to develop new types of antibiotics. Two-component systems (TCSs) are the major signal transduction pathways in bacteria and have emerged as potential targets for antibacterial drugs. Among the 13 pairs of TCSs proteins presenting in <it>S. pneumoniae</it>, VicR/K is the unique one essential for bacterium growth, and block agents to which, if can be found, may be developed as effective antibiotics against <it>S. pneumoniae </it>infection.</p> <p>Results</p> <p>Using a structure-based virtual screening (SBVS) method, 105 compounds were computationally identified as potential inhibitors of the histidine kinase (HK) VicK protein from the compound library SPECS. Six of them were then validated <it>in vitro </it>to be active in inhibiting the growth of <it>S. pneumoniae </it>without obvious cytotoxicity to Vero cell. In mouse sepsis models, these compounds are still able to decrease the mortality of the mice infected by <it>S. pneumoniae </it>and one compound even has significant therapeutic effect.</p> <p>Conclusion</p> <p>To our knowledge, these compounds are the first reported inhibitors of HK with antibacterial activity <it>in vitro </it>and <it>in vivo</it>, and are novel lead structures for developing new drugs to combat pneumococcal infection.</p

Natural Disaster Risk Monitoring for Immovable Cultural Relics Based on Digital Twin

Natural disaster risk monitoring is an important task for disaster prevention and reduction. In the case of immovable cultural relics, however, the feedback mechanism, risk factors, monitoring logic, and monitoring indicators of natural disaster risk monitoring are complex. How to achieve intelligent perception and monitoring of natural disaster risk for immovable cultural relics has always been a focus and a challenge for researchers. Based on the analysis of the concepts and issues related to the natural disaster risk of immovable cultural relics, this paper proposes a framework for natural disaster risk monitoring for immovable cultural relics based on the digital twin. This framework focuses on risk monitoring, including the physical entities of natural disaster risk for immovable cultural relics, monitoring indicators, and virtual entity construction. A platform for monitoring the natural disaster risk of immovable cultural relics is proposed. Using the Puzhou Ancient City Site as a test bed, the proposed concept can be used for monitoring the natural disaster risk of immovable cultural relics at different scales

Changes of Microorganisms and Flavor Compounds in the Fourth Round Jiupei of Sauce-flavored Baijiu in Beijing

Sauce-flavor Baijiu shows a typical sauce flavor, with a delicate mouthfeel. Its fermentation process consists of seven cycles, and each cycle produces one kind of base liquor. The fourth cycle liquor has a rich flavor and excellent quality. During the fermentation process, microorganisms are in a dynamic state, while flavor substances differ. This study investigated the microbial changes of Jiupei in the fourth cycle and their impact on flavor substances. Species diversity analysis was conducted on the fourth cycle Jiupei sample using high-throughput sequencing. Flavor substances were analyzed using headspace solid-phase microextraction combined with gas chromatography-mass spectrometry. Results showed that the dominant bacteria in the Jiupei were Lactobacillus, Virgibacillus, and Kroppenstedtia, while dominant fungi were Thermoascus, Aspergillus, and Issatchenkia. The microbial community in the Jiupei showed significant dynamic changes during the later stage of fermentation. The Jiupei showed the richest variety of alcohol and ester substances at the beginning of fermentation, with the relative content of alcohol, ester, and acid compounds showing a pattern of increasing firstly and then gradually decreased during fermentation. This study conducted a correlation analysis between fungi and bacteria at the genus level and flavor substances, revealing that Monascus, Lactobacillus, and Wickerhamomyces were positively correlated with key flavor substances, such as ethyl acetate, ethyl lactate, and ethyl hexanoate, respectively. The data provided a basis for comparing the microorganisms and flavor substances in the fourth cycle of sauce-flavor Baijiu, and offered a theoretical basis for improving the quality of Baijiu

SHP-2-induced M2 polarization of tumor associated macrophages via IL-4 regulate colorectal cancer progression

ObjectiveTo explore the effect and molecular mechanism of Src homology region 2 domain-containing protein tyrosine phosphatase-2 (SHP-2) in tumor-associated macrophages (TAMs) repressing the migration and invasion of colorectal cancer (CRC) cells.MethodsThe relevant data sets of human colon specimens were obtained from GEO database, and then the performed correlation analysis, principal component analysis and differentially expressed gene (DEGs) analysis on the samples were conducted. GO and KEGG enrichment analysis were performed on the common DEGs, and then functional interaction prediction was performed to verify the gene regulatory circuit of SHP-2. Furthermore, western blot was used to detect the effect of low expression of SHP-2 on related proteins, including the markers of promoting M2 polarization and exosome secretion, and keys proteins of the PI3K pathway. The relationship between SHP-2 and PI3K pathway was further verified by adding PI3K inhibitor LY294002. Finally, the effect of SHP-2 on the function of colon cancer cells was confirmed by wound healing assay and Transwell assay.ResultsThrough bioinformatics analysis, SHP-2 was screened as a possible key gene affecting CRC. The low expression of SHP-2 promoted the protein levels of Arginase-1 and IL-10 in IL-4 induced M2 macrophages, while inhibited the protein levels of IL-1β and TNF-α. Meanwhile, low expression of SHP-2 was found to similarly promote the expression of p-PI3K, p-AKT, and the release of exosomes. Interestingly, the promotion was suppressed after the addition of the PI3K inhibitor LY294002. In terms of cellular behavior, wound healing and transwell data showed that low expression of SHP-2 enhanced the migration and invasion abilities of CRC cells.ConclusionThe low expression of SHP-2 induced by PHPS1 may regulate M2 polarization of TAMs and release of exosomes through PI3K/AKT pathway, thereby enhancing the migration and invasion ability of CRC cells

Process optimization of the first set of fluidized bed methanol to propylene plant

In order to successfully complete the commissioning of the first industrial demonstration unit of methanol to propylene FMTP in fluidized bed, through the investigation and technical exchange of similar enterprises using methanol to olefin (DMTO) technology of Dalian Chemical Institute, methanol to olefin (SMTO) technology of Sinopec, methanol to olefin (SHMTO) technology of Shenhua Group and methanol to propylene technology (MTP) in China, through the comparison and analysis with FMTP process technology, it was found that there were deficiencies in the design of the catalyst recovery system of the original FMTP unit, the catalyst circulation pipeline between the three units, the heat transfer system of washing water, the waste heat recovery system and the reactor measurement instrument system. According to the construction and operation experience of the same industry, the waste catalyst recovery system was designed and transformed into a bucket recovery system. The catalyst circulating pipeline was optimized to be a lifting pipe and a flange tube cap, the xylene cleaning system was optimized to be in the washing water heat exchanger, the steam automatic ash blowing system was optimized to be in the waste heat recovery equipment, and reactor instrument back blower system was optimized to be in the reactor measuring instrument. After the above process optimization, the content of combustible gas in the analytical gas of the catalyst recovery system was significantly reduced, and the catalyst was prevented from sticking together; the catalyst circulation pipelines of the three reactors were designed the lifting tube, the buffer tube and tube cap were designed at the top of the lifting tube; the catalyst circulation between the three reactors was smooth during the operation of the plant, the parameters of the catalyst circulation, the temperature of the tube, the density of the tube and the pressure of the tube in the reactor were close to and reached the design indicators; start the xylene cleaning system to wash the blocked heat exchanger, and the heat exchanger cleaning effect is obvious; after the automatic steam ash blowing system is put into operation, the efficiency of waste heat recovery system is significantly improved; the inert gas of reactor instrument back blower system was optimized to process gas, avoid the influence of inert gas on the downstream separation unit. In the four commissioning runs of FMTP device, the above system runs smoothly, it lays the foundation for the long cycle safe and stable operation of the plant