Comparative effects of mulligan’s mobilization and proprioceptive neuromuscular facilitation technique on pain and disability in patients with sacroiliac joint dysfunction

Purpose: To evaluate the efficacy of Mulligan’s Movement of Mobilization and contract- relax technique on pain and disability in patients suffering from sacroiliac joint Dysfunction. Method: A randomized clinical trial was done at DHQ hospital Jhang. 38 persons including both genders old enough 20-35 years were associated with this review who meet the inclusion criteria were recruited by consecutive sampling technique and allocated to the groups by simple random sampling process and by sealed opaque enveloped labeled as 0 for group A and 1 for group B and indiscriminately allocated into two sets. One set A was specified to mulligan mobilization technique and the second set B was specified to contract-relax technique for 6 weeks as three sessions per week. Baseline treatment of hot pack and ultrasound was given to both groups. All the patients were assessed for pain with NPRS and for disability with MOPDQ before and after treatment. Data was analyzed using SPSS 22. Results: After treatment, both groups significantly improved in terms of pain and disability. Mean value of NPRS was reduced from 6.89±1.15 to 1.68±.58 in MWM Group while in Contract-Relax from 6.78±1.18 to 2.57±.90. Mean Value of MOPDQ improved from 31.00±6.24 to 2.95±.911 and 32.26±7.14 to 4.31±1.20 in MWM and Contract-Relax group. However, group that received mulligan technique had significantly better improved NPRS and MOPDQ values than contract-relax group in patients with Sacro-iliac dysfunction (p<0.05). Conclusion: In the management of sacroiliac joint dysfunction, Mulligan mobilization is more efficient than contract-relax approach

Occupational Health Hazard among Health Care Workers in a Tertiary Care Hospital, Lahore

Background: Occupational health is a neglected public health issue among healthcare workers in developing countries and they may expose them to various forms of hazards. Objectives: The study aims at exploring the forms of occupational health hazards among nurses in a tertiary care hospital, Lahore Methods: Total 151 staff nurses were enrolled for cross-sectional descriptive study to explore the occupational health hazard.  This study was conducted at Lahore General Hospital, Lahore for the duration of 02, 2021, to January 01, 2022. Only charge nurses working in medical and surgical units on permanent basis having experience more than six months were included. Results: The findings of this study showed that the mean age of the nurse was 25.87 ± 3.138 years (age range 21-32 year), the female nurse was  127(84.1%)while 24(15.9%) were male nurse. The participants faced occupational health hazards 51.8%, biological hazards73.5%, and physical hazards 59.2% and mechanical and psychology Hazards among Nurse 48.8% and 52.0% respectively. Conclusion:Occupational risks (biological hazards) are very common among the nurses in Lahore General Hospital, Lahore. To protect patients and medical staff, hospitals should implement preventative, infection control, and patient safety initiatives. Keywords: Occupational hazards;  Health workers;  Lahore General Hospital DOI: 10.7176/JHMN/104-05 Publication date: November 30th 202

Fraxinus

Fraxinus, a member of the Oleaceae family, commonly known as ash tree is found in northeast Asia, north America, east and western France, China, northern areas of Pakistan, India, and Afghanistan. Chemical constituents of Fraxinus plant include various secoiridoids, phenylethanoids, flavonoids, coumarins, and lignans; therefore, it is considered as a plant with versatile biological and pharmacological activities. Its tremendous range of pharmacotherapeutic properties has been well documented including anticancer, anti-inflammatory, antioxidant, antimicrobial, and neuroprotective. In addition, its bioactive phytochemicals and secondary metabolites can be effectively used in cosmetic industry and as a competent antiaging agent. Fraxinus presents pharmacological effectiveness by targeting the novel targets in several pathological conditions, which provide a spacious therapeutic time window. Our aim is to update the scientific research community with recent endeavors with specifically highlighting the mechanism of action in different diseases. This potentially efficacious pharmacological drug candidate should be used for new drug discovery in future. This review suggests that this plant has extremely important medicinal utilization but further supporting studies and scientific experimentations are mandatory to determine its specific intracellular targets and site of action to completely figure out its pharmacological applications

Association of depression with dental caries and periodontal disease at a tertiary care hospital

Published in May - 202

Astragalin: A Bioactive Phytochemical with Potential Therapeutic Activities

Natural products, an infinite treasure of bioactive chemical entities, persist as an inexhaustible resource for discovery of drugs. This review article intends to emphasize on one of the naturally occurring flavonoids, astragalin (kaempferol 3-glucoside), which is a bioactive constituent of various traditional medicinal plants such as Cuscuta chinensis. This multifaceted compound is well known for its diversified pharmacological applications such as anti-inflammatory, antioxidant, neuroprotective, cardioprotective, antiobesity, antiosteoporotic, anticancer, antiulcer, and antidiabetic properties. It carries out the aforementioned activities by the regulation and modulation of various molecular targets such as transcription factors (NF-κB, TNF-α, and TGF-β1), enzymes (iNOS, COX-2, PGE2, MMP-1, MMP-3, MIP-1α, COX-2, PGE-2, HK2, AChe, SOD, DRP-1, DDH, PLCγ1, and GPX), kinases (JNK, MAPK, Akt, ERK, SAPK, IκBα, PI3K, and PKCβ2), cell adhesion proteins (E-cadherin, vimentin PAR-2, and NCam), apoptotic and antiapoptotic proteins (Beclin-1, Bcl-2, Bax, Bcl-xL, cytochrome c, LC3A/B, caspase-3, caspase-9, procaspase-3, procaspase-8, and IgE), and inflammatory cytokines (SOCS-3, SOCS-5, IL-1β, IL-4, IL-6, IL-8, IL-13, MCP-1, CXCL-1, CXCL-2, and IFN-γ). Although researchers have reported multiple pharmacological applications of astragalin in various diseased conditions, further experimental investigations are still mandatory to fully understand its mechanism of action. It is contemplated that astragalin could be subjected to structural optimization to ameliorate its chemical accessibility, to optimize its absorption profiles, and to synthesize its more effective analogues which will ultimately lead towards potent drug candidates

Knowledge, attitude, and practices regarding infection control measures among medical students

Objective: To assess the knowledge, attitude and reported practices of medical students regarding infection control measures.Methods: The cross-sectional, questionnaire-based study was conducted at one public and one private medical university in Karachi from January to February 2016. The students enrolled were in their clinical years of the Bachelor of Medicine, Bachelor of Surgery course and their knowledge, attitude and practice were measured regarding infection control measures. SPSS 19 was used to analyse data.Results: There were 413 medical students with a mean age of 21.78±1.10 years. Overall, 206(49.9%) students were from the private university and 207(50.1%) from the public institution. Students from the private institution had better knowledge compared to those from the public institution regarding hand hygiene (p\u3c0.001), needlestick injuries (p\u3c0.001) and surgical scrubbing (p=0.007), as well as better reported practices regarding hand hygiene (p\u3c0.001) and surgical scrubbing (p=0.001).Conclusions: Knowledge and practices of medical students regarding the method of surgical scrubbing and needlestick injury protocols in particular needed improvement

Antibacterial Activity of Dental Composite with Ciprofloxacin Loaded Silver Nanoparticles

Resin composites have been widely used in dental restoration. However, polymerization shrinkage and resultant bacterial microleakage are major limitations that may lead to secondary caries. To overcome this, a new type of antibacterial resin composite containing ciprofloxacin-loaded silver nanoparticles (CIP-AgNPs) were synthesized. The chemical reduction approach successfully produced CIP-AgNPs, as demonstrated by FTIR, zeta potential, scanning electron microscopy, and ultraviolet-visible (UV-vis) spectroscopy. CIP-AgNPs were added to resin composites and the antibacterial activity of the dental composite discs were realized against Enterococcus faecalis, Streptococcus mutans, and the Saliva microcosm. The biocompatibility of modified resin composites was assessed and mechanical testing of modified dental composites was also performed. The results indicated that the antibacterial activity and compressive strength of resin composites containing CIP-AgNPs were enhanced compared to the control group. They were also biocompatible when compared to resin composites containing AgNPs. In short, these results established strong ground application for CIP-AgNP-modified dental composite resins