2 research outputs found
MOESM2 of Quantitation of glutathione S-transferases in rice (Oryza sativa L.) roots exposed to cadmium by liquid chromatographyâtandem mass spectrometry using isotope-labeled wing peptides as an internal standard
Additional file 2. Comparison of protein concentrations extracted by minimum-step, TCA-acetone and phenol extraction protocols
Fulvestrant‑3 Boronic Acid (ZB716): An Orally Bioavailable Selective Estrogen Receptor Downregulator (SERD)
Orally bioavailable SERDs may offer
greater systemic drug exposure,
improved clinical efficacy, and more durable treatment outcome for
patients with ER-positive endocrine-resistant breast cancer. We report
the design and synthesis of a boronic acid modified fulvestrant (<b>5</b>, ZB716), which binds to ERα competitively (IC<sub>50</sub> = 4.1 nM) and effectively downregulates ERα in both
tamoxifen-sensitive and tamoxifen-resistant breast cancer cells. Furthermore,
It has superior oral bioavailability (AUC = 2547.1 ng·h/mL) in
mice, indicating its promising clinical utility as an oral SERD