Visualization 1.mp4

3D whole-eye OCT image of the left eye of a 26-year-old volunteer, containing the visual axis, the optical axis, and the pupillary axis

Object Function Retrieval by Model-Based Optimization in Fourier Holographic Endoscopy

Holographic endoscopes have garnered extensive attention not only for their compactness but also for their high-resolution and wide-field imaging capabilities. However, their practical use is challenging due to the reliance on Fesnel approximations in the underlying image reconstruction protocol, limiting their real-world applications. In this study, we present a model-based optimization algorithm that successfully retrieves an object function in a fiber bundle holographic endoscope. By developing a mathematical model that eliminates the need for approximations, our optimization extends the working range and expands the field of view of a fiber bundle holographic endoscope while preserving its advantages. These advancements significantly enhance the utility and feasibility of holographic endoscopes for various diagnostic procedures

Visualization 2: In vivo photothermal treatment with real-time monitoring by optical fiber-needle array

Demonstration of PTT and the real-time monitoring with OFNA. Originally published in Biomedical Optics Express on 01 July 2017 (boe-8-7-3482