Interpreting Montana\u27s Pathbreaking Wrongful Discharge from Employment Act: A Preliminary Analysis

Interpreting Montana\u27s Pathbreaking Wrongful Discharge from Employment Act: A preliminary analysi

LLV - Lunar Logistic Vehicle Final report

Evaluation of systems design training institute for engineering facult

CstF-64 is necessary for endoderm differentiation resulting in cardiomyocyte defects

AbstractAlthough adult cardiomyocytes have the capacity for cellular regeneration, they are unable to fully repair severely injured hearts. The use of embryonic stem cell (ESC)-derived cardiomyocytes as transplantable heart muscle cells has been proposed as a solution, but is limited by the lack of understanding of the developmental pathways leading to specification of cardiac progenitors. Identification of these pathways will enhance the ability to differentiate cardiomyocytes into a clinical source of transplantable cells. Here, we show that the mRNA 3′ end processing protein, CstF-64, is essential for cardiomyocyte differentiation in mouse ESCs. Loss of CstF-64 in mouse ESCs results in loss of differentiation potential toward the endodermal lineage. However, CstF-64 knockout (Cstf2E6) cells were able to differentiate into neuronal progenitors, demonstrating that some differentiation pathways were still intact. Markers for mesodermal differentiation were also present, although Cstf2E6 cells were defective in forming beating cardiomyocytes and expressing cardiac specific markers. Since the extraembryonic endoderm is needed for cardiomyocyte differentiation and endodermal markers were decreased, we hypothesized that endodermal factors were required for efficient cardiomyocyte formation in the Cstf2E6 cells. Using conditioned medium from the extraembryonic endodermal (XEN) stem cell line we were able to restore cardiomyocyte differentiation in Cstf2E6 cells, suggesting that CstF-64 has a role in regulating endoderm differentiation that is necessary for cardiac specification and that extraembryonic endoderm signaling is essential for cardiomyocyte development

Further development and testing of a bimodal aerosol dynamics model

April 1994.Also issued as Debra A. Youngblood's thesis (M.S.)- Colorado State University, 1994.Includes bibliographical references.A previously reported bimodal monodisperse aerosol model is further developed and tested. The starting point is the BImodal MOnoDisperse Aerosol Model (BIMODAM I) which was developed to model the formation of ammonium sulfate ((NH4) 2SO4) particles from sulfuric acid (H2SO4) vapor. The model follows the evolution of two monodisperse modes where each mode, i, is characterized by a unique mean diameter and the number of particles with that mean diameter. The aerosol distribution is assumed to undergo typical atmospheric processes such as condensational growth, coagulation, nucleation, and deposition. In BIMODAM I, the effect of each process on the aerosol distribution is represented as a rate equation. The prognostic equations are coupled, so a variable time step differential equation solver is utilized to simultaneously solve the system of equations to predict the mass and number concentration in each mode. The diameter of each mode is diagnosed from the mass and number concentrations. In the first part of this work, two new parameterizations were developed for BIMODAM I. First, a condensation rate factor was developed to account for the lack of polydispersity in the model. Second, a criterion was developed which dictates when the two modes may be merged without generating large errors. In the second part of this work, a new version of the model (BIMODAM II) was developed to give the same accurate results as BIMODAM I without using the variable time step differential equation solver. A key development in BIMODAM II is a parameterization for the process of homogeneous nucleation. This parameterization is based on the approximation of the time-dependent nucleation rate with a triangular function; using this approach, only two parameters are needed to predict the total number of particles resulting from a nucleation event The two parameters are correlated to chemical source rate and relative humidity. Therefore, prediction of the number concentration of particles resulting from a nucleation burst depends on knowing the relative humidity and determining the chemical source rate. This development has been shown to perform well in the presence and absence of preexisting particles and over short and long time scale simulations. Further developments in BIMODAM II include simple analytical solutions of the differential equations for coagulation and deposition. Using a mass balance equation, a simple solution was also derived to predict the amount of sulfuric acid in the vapor phase at any time during the simulation. From this calculation, the amount of mass in the aerosol phase is calculated by subtracting the amount in the vapor phase from the total amount of sulfuric acid produced during any given time step. By using the simplifications and parameterizations mentioned above, computational time is saved by eliminating the variable time stepping differential equation solver. This model is shown to perform well when compared against a simulation which uses a more detailed description of the aerosol size distribution.Sponsored by the Western Regional Center of the National Institute for Global Change W/GEC91-114, and Colorado State University Graduate School

Montana\u27s Wrongful Discharge from Employment Act: The Views of the Montana Bar

Montana\u27s Wrongful Discharge from Employment Act: The views of the Montana ba

The long journey from the giant-monopole resonance to the nuclear-matter incompressibility

Differences in the density dependence of the symmetry energy predicted by nonrelativistic and relativistic models are suggested, at least in part, as the culprit for the discrepancy in the values of the compression modulus of symmetric nuclear matter extracted from the energy of the giant monopole resonance in 208Pb. ``Best-fit'' relativistic models, with stiffer symmetry energies than Skyrme interactions, consistently predict higher compression moduli than nonrelativistic approaches. Relativistic models with compression moduli in the physically acceptable range of K=200-300 MeV are used to compute the distribution of isoscalar monopole strength in 208Pb. When the symmetry energy is artificially softened in one of these models, in an attempt to simulate the symmetry energy of Skyrme interactions, a lower value for the compression modulus is indeed obtained. It is concluded that the proposed measurement of the neutron skin in 208Pb, aimed at constraining the density dependence of the symmetry energy and recently correlated to the structure of neutron stars, will also become instrumental in the determination of the compression modulus of nuclear matter.Comment: 9 pages with 2 (eps) figure

Asymptotic Normalization Coefficients for 13C+p->14N

The $^{13}C(^{14}N,^{13}C)^{14}N$ proton exchange reaction has been measured at an incident energy of 162 MeV. Angular distributions were obtained for proton transfer to the ground and low lying excited states in $^{14}N$. Elastic scattering of $^{14}N$ on $^{13}C$ also was measured out to the rainbow angle region in order to find reliable optical model potentials. Asymptotic normalization coefficients for the system $^{13}C+p\to {}^{14}N$ have been found for the ground state and the excited states at 2.313, 3.948, 5.106 and 5.834 MeV in $^{14}N$. These asymptotic normalization coefficients will be used in a determination of the S-factor for $^{7}Be(p,\gamma)^{8}B$ at solar energies from a measurement of the proton transfer reaction $^{14}N(^{7}Be,^{8}B)^{13}C$.Comment: 5 pages, 6 figure