2,587 research outputs found
IDEF method-based simulation model design and development
The purpose of this study is to provide an IDEF method-based integrated
framework for a business process simulation model to reduce the model development time
by increasing the communication and knowledge reusability during a simulation project. In
this framework, simulation requirements are collected by a function modeling method
(IDEF0) and a process modeling method (IDEF3). Based on these requirements, a
common data model is constructed using the IDEF1X method. From this reusable data
model, multiple simulation models are automatically generated using a database-driven
simulation model development approach. The framework is claimed to help both
requirement collection and experimentation phases during a simulation project by
improving system knowledge, model reusability, and maintainability through the systematic
use of three descriptive IDEF methods and the features of the relational database
technologies. A complex semiconductor fabrication case study was used as a testbed to
evaluate and illustrate the concepts and the framework. Two different simulation software
products were used to develop and control the semiconductor model from the same
knowledge base. The case study empirically showed that this framework could help
improve the simulation project processes by using IDEF-based descriptive models and the
relational database technology. Authors also concluded that this framework could be easily
applied to other analytical model generation by separating the logic from the dataPeer Reviewe
Performance and Fouling in Pre-Denitrification Membrane Bioreactors Treating High-Strength Wastewater from Food Waste Disposers
The study investigated the performance of the pre-denitrification membrane bioreactor (MBR) process to treat high-strength wastewater generated from food waste disposals. Extracellular polymeric substances (EPS) as membrane foulant and microbial community profiles were analyzed under different hydraulic retention time (HRT) operation conditions. The pre-denitrification MBR was effective for treating food wastewater with high chemical oxygen demand (COD)/N resulting in high total nitrogen (TN) removal efficiency. The operational data showed that effluent qualities in terms of COD, TN, and TP improved with longer HRT. However, membrane fouling potential as shown by specific membrane fouling rate and specific resistance to filtration (SRF) increased as HRT increased. The longer HRT conditions or lower influent loading led to higher levels of bound EPS while HRT did not show large effects on the level of soluble microbial products (SMP). The restriction fragment length polymorphism (RFLP) analysis showed similar microbial banding patterns from the sludges generated under different HRT conditions, indicating that HRT had minimal effects on the composition of microbial communities in the system. All these results suggest that the MBR with pre-denitrification is a feasible option for treating high-strength food wastewater and that different HRT conditions could affect the operational performance and the fouling rate, which is governed via changes in microbial responses through EPS in the system
Production of Transgenic Cloned Miniature Pigs with Membrane-bound Human Fas Ligand (FasL) by Somatic Cell Nuclear Transfer
Cell-mediated xenograft rejection, including NK cells and CD8+ CTL, is a major obstacle in successful pig-to-human xenotransplantation. Human CD8+ CTL and NK cells display high cytotoxicity for pig cells, mediated at least in part by the Fas/FasL pathway. To prevent cell-mediated xenocytotoxicity, a membrane-bound form of human FasL (mFasL) was generated as an inhibitor for CTL and NK cell cytotoxicity that could not be cleaved by metalloproteinase to produce putative soluble FasL. We produced two healthy transgenic pigs harboring the mFasL gene via somatic cell nuclear transfer (SCNT). In a cytotoxicity assay using transgenic clonal cell lines and transgenic pig ear cells, the rate of CD8+ CTL-mediated cytotoxicity was significantly reduced in transgenic pig's ear cells compared with that in normal minipig fetal fibroblasts. Our data indicate that grafts of transgenic pigs expressing membrane-bound human FasL control the cellular immune response to xenografts, creating a window of opportunity to facilitate xenograft survival
Fact Sheet on Cardiac Rehabilitation for Cardiovascular Disease in South Korea
Cardiovascular disease (CVD) poses a significant health challenge globally, including in Korea, due to its status as a leading cause of death and its impact on cardiopulmonary function. Cardiac rehabilitation (CR) is a well-established program that not only aids in restoring cardiopulmonary function, but also improves physical and social conditions. The benefits of CR are widely recognized, and it is implemented globally. While the effectiveness of CR has been proven in Korea, it is underutilized. This fact sheet summarizes the current status of CR in Korea, including the prevalence of CVD, the clinical practice guidelines for CR programs, and the challenges of implementing CR in Korea
Dirac Bilayer Metasurfaces as an Inverse Gires-Tournois Etalon
Efficient transmissive pure-phase resonances are highly desirable for optical
modulation and wavefront engineering. Here, we propose a novel principle to
realize a pure-phase resonance in an extremely broad transmission band, as
opposed to previous approaches restricted to operating in reflection mode or
over a narrow spectral band. We show that a glide-symmetric bilayer metasurface
mathematically mimicking a two-dimensional Dirac semimetal induces
unidirectional guided-mode excitation and perfect leakage-radiation blazing at
the transmission channel. These effects create a peculiar resonant-scattering
configuration, similar to the classical reflective Gires-Tournois etalon, but
in transmission, providing full 2pi phase modulation with constant
transmittance near 100%. Most importantly, this effect persists over an
extremely wide band, associated with topological effects. Hence, our proposed
approach produces a spectrally and parametrically robust pure-phase resonance
effect in transmission, which is highly beneficial for practical applications.Comment: 11 pages, 5 figure
Assessment of satellite rainfall nowcasting based on extrapolation technique
Póster presentado en: 3rd European Nowcasting Conference, celebrada en la sede central de AEMET en Madrid del 24 al 26 de abril de 2019
Heat Shock Protein: Hard Worker or Bad Offender for Gastric Diseases
Heat shock proteins (HSPs) have core housekeeping functions in the cells where they are built-in components of folding, signal transduction pathways, and quality control functions for which they proofread the structure of proteins and repair misfolded conformers. Helicobacter pylori (H. pylori) infection leads to significant inflammations in the gastric mucosa, which is closely associated with development of either precancerous lesion including chronic atrophic gastritis or gastric cancer in addition to, peptic ulcer disease, and mucosa-associated lymphoid tissue (MALT) lymphoma. Therefore, the association between H. pylori infection and role of HSP has been focused as an important issue because there had been rather conflicting publications showing that HSPs as a good worker for defense against H. pylori infection, whereas HSPs as a bad offender contributing to the progression of H. pylori-associated gastric carcinogenesis in addition to aggravation of gastric inflammation. In this paper regarding proteomic discovery of HSPs related to H. pylori-associated gastric diseases, we introduce several evidences obtained from proteomic analysis dealing with friend or foe role of HSP in H. pylori infection from a cellular level to human diseases. The implication of HSPs in alcoholic or NSAIDs-induced gastritis and the intervening of HSPs in biological changes exemplified with TGF-β signaling, key tumor suppressor growth factors regulating inflammation, immune function, and carcinogenesis were further introduced
GAIT ANALYSIS OF THE NORMAL AND ACL DEFICIENT PATIENTS AFTER LIGAMENT RECONSTRUCTION SURGERY
Anterior cruciate ligament (ACL) injury of the knee is common in sports. A serious ACL injury leads to ligament reconstruction surgery. In order to evaluate result of surgery or optimize the rehabilitation process, a knee condition must be objectively identified. The purpose of this study is, therefore, to numerically indicate and classify knee condition of patients via the chaos analysis. Lyapunov exponents (LyEs) were used for the comparison of the normal and the patients
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