3,333 research outputs found
Rural childrenās work and school education in the context of rapid economic growth in South Korea
This paper explores how childrenās work, in its broadest sense, and the related values and attitudes concerning childhood, have evolved in the context of rapid economic growth in South Korea. It discusses how ideas about childrenās main activities, and their status and relationships within the family, have changed and how childrenās roles and responsibilities are seen by members of different generations. It interrogates the changing ideas of work in contemporary childrenās lives and presents data from a relatively under-researched part of the world
Cancer stem cell metabolism: target for cancer therapy
Increasing evidence suggests that cancer stem cell (CSC) theory represents an important mechanism underlying the observed failure of existing therapeutic modalities to fully eradicate cancers. In addition to their more established role in maintaining minimal residual disease after treatment and forming the new bulk of the tumor, CSCs might also critically contribute to tumor recurrence and metastasis. For this reason, specific elimination of CSCs may thus represent one of the most important treatment strategies. Emerging evidence has shown that CSCs have a different metabolic phenotype to that of differentiated bulk tumor cells, and these specific metabolic activities directly participate in the process of CSC transformation or support the biological processes that enable tumor progression. Exploring the role of CSC metabolism and the mechanism of the metabolic plasticity of CSCs has become a major focus in current cancer research. The targeting of CSC metabolism may provide new effective therapies to reduce the risk of recurrence and metastasis. In this review, we summarize the most significant discoveries regarding the metabolism of CSCs and highlight recent approaches in targeting CSC metabolism
Temperature dependence of Mott transition in VO_2 and programmable critical temperature sensor
The temperature dependence of the Mott metal-insulator transition (MIT) is
studied with a VO_2-based two-terminal device. When a constant voltage is
applied to the device, an abrupt current jump is observed with temperature.
With increasing applied voltages, the transition temperature of the MIT current
jump decreases. We find a monoclinic and electronically correlated metal (MCM)
phase between the abrupt current jump and the structural phase transition
(SPT). After the transition from insulator to metal, a linear increase in
current (or conductivity) is shown with temperature until the current becomes a
constant maximum value above T_{SPT}=68^oC. The SPT is confirmed by micro-Raman
spectroscopy measurements. Optical microscopy analysis reveals the absence of
the local current path in micro scale in the VO_2 device. The current uniformly
flows throughout the surface of the VO_2 film when the MIT occurs. This device
can be used as a programmable critical temperature sensor.Comment: 4 pages, 3 figure
Anti-obesity effects of Yerba Mate (Ilex Paraguariensis): a randomized, double-blind, placebo-controlled clinical trial
Dietary assessment parameters of the Yerba Mate and placebo groups measured at 0, 6 and 12ĆĀ weeks. (DOC 37.5 kb
Crystal Structure of Human Mre11: Understanding Tumorigenic Mutations
SummaryMre11 plays an important role in repairing damaged DNA by cleaving broken ends and by providingĀ a platform for other DNA repair proteins. Various Mre11 mutations have been identified in several types of cancer. We have determined the crystal structure of the human Mre11 core (hMre11), which contains the nuclease and capping domains. hMre11 dimerizes through the interfaces between loop Ī²3-Ī±3 from one Mre11 and loop Ī²4-Ī²5 from another Mre11, and between loop Ī±2-Ī²3 from one Mre11 and helices Ī±2 and Ī±3 from another Mre11, and assembles into a completely different dimeric architecture compared with bacterial or archaeal Mre11 homologs. Nbs1 binds to the region containing loop Ī±2-Ī²3 which participates in dimerization. The hMre11 structure in conjunction with biochemical analyses reveals that many tumorigenic mutations are primarily associated with Nbs1 binding and partly with nuclease activities, providingĀ a framework for understanding how mutations inactivate Mre11
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