Effect of backwashing on perchlorate removal in fixed bed biofilm reactors

The influence of backwashing on biological perchlorate reduction was evaluated in two laboratory scale fixed bed biofilm reactors using 1- or 3-mm glass beads as support media. Influent perchlorate concentrations were 50 μg/L and acetate was added as the electron donor at a concentration of 2 mg C/L. Perchlorate removal was evaluated at various influent dissolved oxygen (DO) concentrations. Complete perchlorate removal was achieved with an influent DO concentration of 1 mg/L resulting in bulk phase DO concentrations below the detection limit of 0.01 mg/L. The influence of increasing influent DO concentrations for 12 h periods was evaluated before and after individual backwash events. Partial perchlorate removal was achieved with an influent DO concentration of 3.5 mg/L before a strong backwash (bulk phase DO concentrations of approximately 0.2 mg/L), while no perchlorate removal was observed after the strong backwash at the same influent DO level (bulk phase DO concentrations of approximately 0.8 mg/L). The immediate effect of backwashing depended on influent DO concentrations. With influent DO concentrations of 1 mg/L, strong backwashing resulted in a brief (\u3c12 h) increase of effluent perchlorate concentrations up to 20 μg/L; more pronounced effects were observed with influent DO concentrations of 3 mg/L. Daily weak backwashing had a small and, over time, decreasing negative influence on perchlorate reduction, while daily strong backwashing ultimately resulted in the breakdown of perchlorate removal with influent DO concentrations of 3 mg/L

Plasmacytoid Dendritic Cells Contribute to the Protective Immunity Induced by Intranasal Treatment with Fc-fused Interleukin-7 against Lethal Influenza Virus Infection

Developing a novel vaccine that can be applied against multiple strains of influenza virus is of utmost importance to human health. Previously, we demonstrated that the intranasal introduction of Fc-fused IL-7 (IL-7-mFc), a long-acting cytokine fusion protein, confers long-lasting prophylaxis against multiple strains of influenza A virus (IAV) by inducing the development of lung-resident memory-like T cells, called TRM-like cells. Here, we further investigated the mechanisms of IL-7-mFc-mediated protective immunity to IAVs. First, we found that IL-7-mFc treatment augments the accumulation of pulmonary T cells in 2 ways: recruiting blood circulating T cells into the lung and expanding T cells at the lung parenchyma. Second, the blockade of T cell migration from the lymph nodes (LNs) with FTY720 treatment was not required for mounting the protective immunity to IAV with IL-7-mFc, suggesting a more important role of IL-7 in T cells in the lungs. Third, IL-7-mFc treatment also recruited various innate immune cells into the lungs. Among these cells, plasmacytoid dendritic cells (pDCs) play an important role in IL-7-mFc-mediated protective immunity through reducing the immunopathology and increasing IAV-specific cytotoxic T lymphocyte (CTL) responses. In summary, our results show that intranasal treatment with IL-7-mFc modulates pulmonary immune responses to IAV, affecting both innate and adaptive immune cells. ? 2017. The Korean Association of Immunologists.112Ysciescopuskc

Effects of Suspension Training on Core Stability and Functional Movement Screen Scores in Healthy Adult Men

OBJECTIVES The purpose of this study is to determine whether suspension training can be an effective intervention in improving functional movement in healthy adult men. METHODS The recruited subjects of Twenty healthy adult men without musculoskeletal diseases were divided into group that performed TRX exercise (n=10) and a group that performed traditional OKC exercise using a resistance machine (n=10). The variables were the deep squat, hurdle step, inline lunge, shoulder mobility, leg raise, push-up, and rotational stability after an 8-week exercise program. The total score of the 7 movements was calculated to compare and analyze the before-and-after changes in FMS score. All the data obtained in this study were analyzed with SPSS package (ver 21.0). To examine the effects of the suspension training program used in this study, Repeated measures ANOVA was conducted to compare the effects before and after the participation in the program. RESULTS The research results are as follows; The results of the FMS evaluation scores showed no significant differences between the TRX group and the OKC group in the deep squat, hurdle step, inline lunge, shoulder mobility, leg raise, and push-up evaluations, and no interaction effect was found. However, the rotational stability evaluation score showed higher scores in the TRX group after training, showing a significant interaction effect (p<.001). The change in total evaluation score also significantly increased in the TRX group (p<.05), but there was no significant difference in the OKC group. CONCLUSIONS In conclusion, rotational stability and total evaluation scores increased after training in the TRX group. In particular, TRX training using suspension may be more effective than traditional forms of training using resistance exercise equipment for people who have instability in the multi-plane stability of the pelvis, core, and shoulder girdle, which are involved in rotational stability