13,125 research outputs found
Pharmacological activation of FOXO3 suppresses triple-negative breast cancer in vitro and in vivo
Triple-negative breast cancer (TNBC) is the most lethal form of breast cancer. Lacking effective therapeutic options hinders treatment of TNBC. Here, we show that bepridil (BPD) and trifluoperazine (TFP), which are FDA-approved drugs for treatment of schizophrenia and angina respectively, inhibit Akt-pS473 phosphorylation and promote FOXO3 nuclear localization and activation in TNBC cells. BPD and TFP inhibit survival and proliferation in TNBC cells and suppress the growth of TNBC tumors, whereas silencing FOXO3 reduces the BPD- and TFP-mediated suppression of survival in TNBC cells. While BPD and TFP decrease the expression of oncogenic c-Myc, KLF5, and dopamine receptor DRD2 in TNBC cells, silencing FOXO3 diminishes BPD- and TFP-mediated repression of the expression of these proteins in TNBC cells. Since c-Myc, KLF5, and DRD2 have been suggested to increase cancer stem cell-like populations in various tumors, reducing these proteins in response to BPD and TFP suggests a novel FOXO3-dependent mechanism underlying BPD- and TFP-induced apoptosis in TNBC cells
Acquire information about neutrino parameters by detecting supernova neutrinos
We consider the supernova shock effects, the Mikheyev-Smirnov-Wolfenstein
(MSW) effects, the collective effects, and the Earth matter effects in the
detection of type II supernova neutrinos on the Earth. It is found that the
event number of supernova neutrinos depends on the neutrino mass hierarchy, the
neutrino mixing angle , and neutrino masses. Therefore, we propose
possible methods to identify the mass hierarchy and acquire information about
and neutrino masses by detecting supernova neutrinos. We apply
these methods to some current neutrino experiments.Comment: 21 pages, 11 figure
R-parity violation and top quark polarization at the Fermilab Tevatron collider
The lepton or baryon number violating top quark interactions in the
supersymmetric standard model with R parity violation contribute to the process
d dbar to t tbar at the tree level via the t- or u-channel sfermion exchange.
Since these interactions are chiral, they induce polarization to the top quark
in the t tbar events at hadron colliders. We show in this article that the
polarization can be a useful observable for probing these interactions at the
upgraded Fermilab Tevatron collider, because the polarization is expected to be
very small in the standard model.Comment: 15 pages, 5 figure
Dynamics and transport in random quantum systems governed by strong-randomness fixed points
We present results on the low-frequency dynamical and transport properties of
random quantum systems whose low temperature (), low-energy behavior is
controlled by strong disorder fixed points. We obtain the momentum and
frequency dependent dynamic structure factor in the Random Singlet (RS) phases
of both spin-1/2 and spin-1 random antiferromagnetic chains, as well as in the
Random Dimer (RD) and Ising Antiferromagnetic (IAF) phases of spin-1/2 random
antiferromagnetic chains. We show that the RS phases are unusual `spin metals'
with divergent low-frequency spin conductivity at T=0, and we also follow the
conductivity through novel `metal-insulator' transitions tuned by the strength
of dimerization or Ising anisotropy in the spin-1/2 case, and by the strength
of disorder in the spin-1 case. We work out the average spin and energy
autocorrelations in the one-dimensional random transverse field Ising model in
the vicinity of its quantum critical point. All of the above calculations are
valid in the frequency dominated regime \omega \agt T, and rely on previously
available renormalization group schemes that describe these systems in terms of
the properties of certain strong-disorder fixed point theories. In addition, we
obtain some information about the behavior of the dynamic structure factor and
dynamical conductivity in the opposite `hydrodynamic' regime for
the special case of spin-1/2 chains close to the planar limit (the quantum x-y
model) by analyzing the corresponding quantities in an equivalent model of
spinless fermions with weak repulsive interactions and particle-hole symmetric
disorder.Comment: Long version (with many additional results) of Phys. Rev. Lett. {\bf
84}, 3434 (2000) (available as cond-mat/9904290); two-column format, 33 pages
and 8 figure
Probing anomalous top quark interactions at the Fermilab Tevatron Collider
We study the effects of dimension-six operators contributing to the vertex in top quark pair production at the Tevatron collider. We derive both
the limits from Run 1 data and the potential bounds from future runs (Run 2 and
3). Although the current constraints are not very strong, the future runs are
quite effective in probing these operators. We investigate the possibility of
disentangling different operators with the invariant mass
distribution and the top quark polarization asymmetry. We also study the
effects of a different set of operators contributing to single top production
via the coupling. We derive the current and potential future bounds
on these anomalous operators and find that the upgraded Tevatron can improve
the existing constraints from for one of the operators.Comment: 20 pages, 2 figures, REVTEX, some clarifying remarks adde
On a Linear Program for Minimum-Weight Triangulation
Minimum-weight triangulation (MWT) is NP-hard. It has a polynomial-time
constant-factor approximation algorithm, and a variety of effective polynomial-
time heuristics that, for many instances, can find the exact MWT. Linear
programs (LPs) for MWT are well-studied, but previously no connection was known
between any LP and any approximation algorithm or heuristic for MWT. Here we
show the first such connections: for an LP formulation due to Dantzig et al.
(1985): (i) the integrality gap is bounded by a constant; (ii) given any
instance, if the aforementioned heuristics find the MWT, then so does the LP.Comment: To appear in SICOMP. Extended abstract appeared in SODA 201
Dimension-six CP-conserving operators of the third-family quarks and their effects on collider observables
We list all possible dimension-six CP-conserving invariant operators involving the third-family quarks which
could be generated by new physics at a higher scale. Expressions for these
operators after electroweak gauge symmetry breaking and the induced effective
couplings , and are
presented. Analytic expressions for the tree level contributions of all these
operators to the observables and at LEP I,
and at LEP II,
and at the NLC, as well as
at the Tevatron upgrade, are provided.
The effects of these operators on different electroweak observables are
discussed and numerical examples presented. Numerical analyses show that in the
coupling region allowed by and at LEP I, some of the new
physics operators can still have significant contributions at LEP II, the
Tevatron and the NLC.Comment: 25 page
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