Chiral effective field theory beyond the power-counting regime

Novel techniques are presented, which identify the chiral power-counting regime (PCR), and realize the existence of an intrinsic energy scale embedded in lattice QCD results that extend outside the PCR. The nucleon mass is considered as a benchmark for illustrating this new approach. Using finite-range regularization, an optimal regularization scale can be extracted from lattice simulation results by analyzing the renormalization of the low energy coefficients. The optimal scale allows a description of lattice simulation results that extend beyond the PCR by quantifying and thus handling any scheme-dependence. Preliminary results for the nucleon magnetic moment are also examined, and a consistent optimal regularization scale is obtained. This indicates the existence of an intrinsic scale corresponding to the finite size of the source of the pion cloud.Comment: 6 pages, 4 figures, conferenc

Accurate prediction of gene feedback circuit behavior from component properties

A basic assumption underlying synthetic biology is that analysis of genetic circuit elements, such as regulatory proteins and promoters, can be used to understand and predict the behavior of circuits containing those elements. To test this assumption, we used time‐lapse fluorescence microscopy to quantitatively analyze two autoregulatory negative feedback circuits. By measuring the gene regulation functions of the corresponding repressor–promoter interactions, we accurately predicted the expression level of the autoregulatory feedback loops, in molecular units. This demonstration that quantitative characterization of regulatory elements can predict the behavior of genetic circuits supports a fundamental requirement of synthetic biology

Hepatitis B among Pacific Islanders in Southern California: how is health information associated with screening and vaccination?

We measured Hepatitis B virus (HBV) transmission knowledge and self-reported screening/testing behavior among Pacific Islanders (Guamanians/Chamorros, Samoans, and Tongans) in Southern California. We also examined access and trust by Pacific Islanders of varying health information sources. We administered and analyzed survey data (N = 297), using a convenience sample in Los Angeles, Orange, and San Diego Counties in spring 2009. We found that while Pacific Islander respondents reported that they receive health information from physicians, and largely trust this source, information from and trust in physicians were not statistically significant in explaining whether respondents sought HBV screening or vaccination

Lattice QCD Evidence that the Lambda(1405) Resonance is an Antikaon-Nucleon Molecule

For almost 50 years the structure of the Lambda(1405) resonance has been a mystery. Even though it contains a heavy strange quark and has odd parity, its mass is lower than any other excited spin-1/2 baryon. Dalitz and co-workers speculated that it might be a molecular state of an antikaon bound to a nucleon. However, a standard quark-model structure is also admissible. Although the intervening years have seen considerable effort, there has been no convincing resolution. Here we present a new lattice QCD simulation showing that the strange magnetic form factor of the Lambda(1405) vanishes, signaling the formation of an antikaon-nucleon molecule. Together with a Hamiltonian effective-field-theory model analysis of the lattice QCD energy levels, this strongly suggests that the structure is dominated by a bound antikaon-nucleon component. This result clarifies that not all states occurring in nature can be described within a simple quark model framework and points to the existence of exotic molecular meson-nucleon bound states.Comment: Manuscript accepted for publication. 4 figures, 5 page

SMA Imaging of the Maser Emission from the H30α\alpha Radio Recombination Line in MWC349A

We used the Submillimeter Array to map the angular distribution of the H30$\alpha$ recombination line (231.9 GHz) in the circumstellar region of the peculiar star MWC349A. The resolution was 1\farcs2, but because of high signal-to-noise ratio we measured the positions of all maser components to accuracies better than 0\farcs01, at a velocity resolution of $1 kms$. The two strongest maser components (called high velocity components) at velocities near -14 and $32 kms$ are separated by 0\farcs048 \pm 0\farcs001 (60 AU) along a position angle of 102 \pm 1\arcdeg. The distribution of maser emission at velocities between and beyond these two strongest components were also provided. The continuum emission lies at the center of the maser distribution to within 10 mas. The masers appear to trace a nearly edge-on rotating disk structure, reminiscent of the water masers in Keplerian rotation in the nuclear accretion disk of the galaxy NGC4258. However, the maser components in MWC349A do not follow a simple Keplerian kinematic prescription with $v \sim r^{-1/2}$, but have a larger power law index. We explore the possibility that the high velocity masers trace spiral density or shock waves. We also emphasize caution in the interpretation of relative centroid maser positions where the maser is not clearly resolved in position or velocity, and we present simulations that illustrate the range of applicability of the centroiding method.Comment: 23 pages with 9 figures (two of these figures are vertically aligned as Figure 4) submitted to the Astrophysical Journa

Thiazolidinediones Regulate Adipose Lineage Dynamics

SummaryWhite adipose tissue regulates metabolism; the importance of this control is highlighted by the ongoing pandemic of obesity and associated complications such as diabetes, atherosclerosis, and cancer. White adipose tissue maintenance is a dynamic process, yet very little is known about how pharmacologic stimuli affect such plasticity. Combining in vivo lineage marking and BrdU labeling strategies, we found that rosiglitazone, a member of the thiazolidinedione class of glucose-lowering medicines, markedly increases the evolution of adipose progenitors into adipocytes. Notably, chronic rosiglitazone administration disrupts the adipogenic and self-renewal capacities of the stem cell compartment and alters its molecular characteristics. These data unravel unknown aspects of adipose dynamics and provide a basis to manipulate the adipose lineage for therapeutic ends

Perceived Ability to Treat Opioid Use Disorder in West Virginia

Introduction: Medication-assisted treatment (MAT) is an evidence-based therapy for opioid use disorder (OUD) that has not been fully implemented in rural areas due to patient, provider, and logistical barriers. Limited information is available on provider perceptions of barriers to MAT in rural Central Appalachia which has very high rates of OUD compared to the rest the United States. Purpose: Determine perceived barriers for potential prescribers to using MAT, including buprenorphine, as part of treatment for OUD in West Virginia. Methods: A 30-question, anonymous survey was sent to physicians, physician assistants and advanced practice registered nurses using an online link. Link was distributed through the WV Medicaid provider list, professional association and institutional contact lists, and social media. Comparisons were made by provider waivered or non-waivered status. Results: Overall, 84% of waivered providers (n = 77) and only 8% of non-waivered providers (n = 341) indicated ever prescribing a form of MAT for OUD; 73% percent of waivered providers were currently prescribing MAT and accepting new patients with OUD. Only 4% of non-waivered providers were currently prescribing MAT and 21% were currently accepting new patients with OUD. Lack of available mental health and psychosocial support services and concerns about diversion or misuse of medication were the top perceived barriers to implementing MAT programs. Implications: Implementing strategies to improve access to behavioral health care including telehealth and apps, provider training and addressing stigma around OUD treatment were identified as priorities that would help increase providers’ willingness to prescribe medications for OUD treatment

Neural evidence for "intuitive prosecution": The use of mental state information for negative moral verdicts

Moral judgment depends critically on theory of mind (ToM), reasoning about mental states such as beliefs and intentions. People assign blame for failed attempts to harm and offer forgiveness in the case of accidents. Here we use fMRI to investigate the role of ToM in moral judgment of harmful vs. helpful actions. Is ToM deployed differently for judgments of blame vs. praise? Participants evaluated agents who produced a harmful, helpful, or neutral outcome, based on a harmful, helpful, or neutral intention; participants made blame and praise judgments. In the right temporo-parietal junction (right TPJ), and, to a lesser extent, the left TPJ and medial prefrontal cortex, the neural response reflected an interaction between belief and outcome factors, for both blame and praise judgments: The response in these regions was highest when participants delivered a negative moral judgment, i.e., assigned blame or withheld praise, based solely on the agent's intent (attempted harm, accidental help). These results show enhanced attention to mental states for negative moral verdicts based exclusively on mental state information.Athinoula A. Martinos Center for Biomedical ImagingSimons FoundationNational Science Foundation (U.S.)John Merck Scholars Progra