DMN hub configurations preceding acupuncture and following acupuncture at ST36 or NAP within the gamma band (P<0.05, FDR corrected).

<p>The DMN hubs are indicated in red which are denoted as at least one standard deviation greater than the average degree of the network. The strength of the functional connectivity was expressed by the thickness of the green line. L, left; R, right; MFG, medial frontal gyrus; SFG, superior frontal gyrus; ACC, anterior cingulate cortex; PCC, posterior cingulate cortex/precuneus; STG, superior temporal gyrus; AG, angular gyrus; IPL, inferior parietal lobule; MTG, middle temporal gyrus.</p

The functional connectivity between the DMN key nodes and their alterations induced by acupuncture within the theta band (4–8 Hz).

<p>The maximum of the 4 pairwise connections obtained from the two ROIs located in both hemispheres was defined as the connectivity between the two nodes (one sample <i>t</i>-test, <i>P</i><0.05). Significant alterations induced by acupuncture at ST36 relative to NAP were based on the paired <i>t</i>-test (<i>P</i><0.05) or with the emergence/suspension of functional connectivity following acupuncture compared with the resting state.</p

Brain areas with significant different ReHo values between MCI and HC groups during the resting state are shown.

<p>Warm and cool colors indicate the significantly increased and decreased ReHo values in MCI patients compared with healthy controls at P<0.01 (Alphasim corrected, p<0.01, 30 voxels). (Abbreviation: PCG- Precentral Gyrus).</p

Brain areas with significant different ReHo values between MCI patients and healthy controls during the resting state at <i>P</i><0.01 (Alphasim corrected, <i>p</i><0.01, 30 voxels).

<p>Brain areas with significant different ReHo values between MCI patients and healthy controls during the resting state at <i>P</i><0.01 (Alphasim corrected, <i>p</i><0.01, 30 voxels).</p

DMN hub configurations preceding acupuncture and following acupuncture at ST36 or NAP within the theta band (P<0.05, FDR corrected).

<p>The DMN hubs are indicated in red which are denoted as at least one standard deviation greater than the average degree of the network. The strength of the functional connectivity was expressed by the thickness of the green line. L, left; R, right; MFG, medial frontal gyrus; SFG, superior frontal gyrus; ACC, anterior cingulate cortex; PCC, posterior cingulate cortex/precuneus; STG, superior temporal gyrus; AG, angular gyrus; IPL, inferior parietal lobule; MTG, middle temporal gyrus.</p

Averaged psychophysical response.

<p>A. The percentage of subjects that reported the given sensations. The frequency of aching was found greater following acupuncture at ST36. B. The intensity of sensations measured by average score (with standard error bars) on a scale from 0 denoting no sensation to 10 denoting an unbearable sensation. Sore, soreness; Numb, numbness; Full, fullness; Heav, heaviness; Warm, warmth; DP, dull pain; Tinl, tingling; Cool, coolness; Ach, aching; Press, pressure.</p

DMN hub configurations preceding acupuncture and following acupuncture at ST36 or NAP within the beta band (P<0.05, FDR corrected).

<p>The DMN hubs are indicated in red which are denoted as at least one standard deviation greater than the average degree of the network. The strength of the functional connectivity was expressed by the thickness of the green line. L, left; R, right; MFG, medial frontal gyrus; SFG, superior frontal gyrus; ACC, anterior cingulate cortex; PCC, posterior cingulate cortex/precuneus; STG, superior temporal gyrus; AG, angular gyrus; IPL, inferior parietal lobule; MTG, middle temporal gyrus.</p

Brain areas with significant different ReHo values in the healthy controls after acupuncture at <i>P</i><0.01 (Alphasim corrected, <i>p</i><0.01, 30 voxels).

<p>Brain areas with significant different ReHo values in the healthy controls after acupuncture at <i>P</i><0.01 (Alphasim corrected, <i>p</i><0.01, 30 voxels).</p

Brain areas with significant different ReHo values in the MCI patients after acupuncture at <i>P</i><0.01 (Alphasim corrected, <i>p</i><0.01, 30 voxels).

<p>Brain areas with significant different ReHo values in the MCI patients after acupuncture at <i>P</i><0.01 (Alphasim corrected, <i>p</i><0.01, 30 voxels).</p

The DMN hub configurations during the resting state (REST), following sham acupuncture (NAP) and verum acupuncture (ST36) within the 5 frequency bands respectively.

<p>Abbreviations as in <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0064509#pone-0064509-t001" target="_blank">Table 1</a>.</p