2 research outputs found
Base-Promoted Formal [4 + 3] Annulation between 2<i>-</i>Fluorophenylacetylenes and Ketones: A Route to Benzoxepines
The
first base-promoted formal [4 + 3] annulation between 2-fluorophenylacetylenes
and ketones has been disclosed. The reaction proceeds through a tandem
α-vinylation of ketones followed by an intramolecular nucleophilic
aromatic substitution (S<sub>N</sub>Ar) reaction of the <i>in
situ</i> generated β,γ-unsaturated ketone intermediates,
providing a straightforward access to a wide range of functionalized
benzoxepines in moderate to high yields. The transition-metal-free
methodology featured a wide substrate scope, the use of easily available
starting materials, and a high functional group tolerance
Base-Promoted Formal [4 + 3] Annulation between 2<i>-</i>Fluorophenylacetylenes and Ketones: A Route to Benzoxepines
The
first base-promoted formal [4 + 3] annulation between 2-fluorophenylacetylenes
and ketones has been disclosed. The reaction proceeds through a tandem
α-vinylation of ketones followed by an intramolecular nucleophilic
aromatic substitution (S<sub>N</sub>Ar) reaction of the <i>in
situ</i> generated β,γ-unsaturated ketone intermediates,
providing a straightforward access to a wide range of functionalized
benzoxepines in moderate to high yields. The transition-metal-free
methodology featured a wide substrate scope, the use of easily available
starting materials, and a high functional group tolerance