Classification of bifurcation diagrams in coupled phase-oscillator models with asymmetric natural frequency distributions

Synchronization among rhythmic elements is modeled by coupled phase-oscillators each of which has the so-called natural frequency. A symmetric natural frequency distribution induces a continuous or discontinuous synchronization transition from the nonsynchronized state, for instance. It has been numerically reported that asymmetry in the natural frequency distribution brings new types of bifurcation diagram having, in the order parameter, oscillation or a discontinuous jump which emerges from a partially synchronized state. We propose a theoretical classification method of five types of bifurcation diagrams including the new ones, paying attention to the generality of the theory. The oscillation and the jump from partially synchronized states are discussed respectively by the linear analysis around the nonsynchronized state and by extending the amplitude equation up to the third leading term. The theoretical classification is examined by comparing with numerically obtained one.Comment: 18 pages, 14 figure

The origin of MeV gamma-ray diffuse emission from the inner Galactic region

The origin of the inner Galactic emission, measured by COMPTEL with a flux of $\sim ~ 10^{-2}$ MeV cm$^{-2}$ s$^{-1}$ sr$^{-1}$ in the 1-30 MeV range, has remained unsettled since its discovery in 1994. We investigate the origin of this emission by taking into account individual sources which are not resolved by COMPTEL and the Galactic diffuse emission. The source contribution is estimated for sources crossmatched between the Swift-BAT and Fermi-LAT catalogs by interpolating the energy spectra in the hard X-ray and GeV gamma-ray ranges, as well as unmatched sources. This results in a flux of $\sim$20% of the COMPTEL excess. The Galactic diffuse emission is calculated by GALPROP to reconcile the cosmic-ray and gamma-ray spectra with observations by AMS-02, Voyager, and Fermi-LAT, resulting in a flux of $\sim$30-80% of the COMPTEL emission. Thus, we show that the COMPTEL emission could be roughly reproduced by a combination of the sources and the Galactic diffuse emission. Furthermore, combined with the extragalactic emission, we construct all-sky images in the MeV gamma-ray range to pinpoint some potential interesting targets for future missions, which would be critical for bridging the MeV gap in the spectra of gamma-ray sources.Comment: Proceedings of Science; 7th Heidelberg International Symposium on High-Energy Gamma-Ray Astronomy (Gamma2022), 4-8 July 2022, Barcelona, Spai

Low-power display system enabled by combining oxide semiconductor and neural network technologies

An oxide semiconductor (OS)-based field effect transistor (OSFET) exhibits the advantage of having an extremely low off-state current; moreover, the OSFET displays an off-state current that is ten orders of magnitude lower than that of a CMOS-FET [1]. Recently, numerous applications that harness this feature have been reported [2]. For instance, charge leakage from a data retention node of a pixel significantly decreases when the display incorporates OSFETs in its pixel circuit (OS display) [3, 4]. This minimizes degradation in the image quality when the displayed image is static despite using lower refresh rates. Consequently, the consumed power of the display driver circuit can be reduced by a large margin. This driving method is termed idling stop (IDS) driving. The OSFET’s low-leakage can also effectively enable a type of ULSICs that we term OS-large-scale integrated circuits (OSLSI) [5, 6]. Please click Additional Files below to see the full abstract

Importin Alpha Subtypes Determine Differential Transcription Factor Localization in Embryonic Stem Cells Maintenance

SummaryWe recently demonstrated that the expression of the importin α subtype is switched from α2 to α1 during neural differentiation in mouse embryonic stem cells (ESCs) and that this switching has a major impact on cell differentiation. In this study, we report a cell-fate determination mechanism in which importin α2 negatively regulates the nuclear import of certain transcription factors to maintain ESC properties. The nuclear import of Oct6 and Brn2 was inhibited via the formation of a transport-incompetent complex of the cargo bound to a nuclear localization signal binding site in importin α2. Unless this dominant-negative effect was downregulated upon ESC differentiation, inappropriate cell death was induced. We propose that although certain transcription factors are necessary for differentiation in ESCs, these factors are retained in the cytoplasm by importin α2, thereby preventing transcription factor activity in the nucleus until the cells undergo differentiation

The whole blood transcriptional regulation landscape in 465 COVID-19 infected samples from Japan COVID-19 Task Force

「コロナ制圧タスクフォース」COVID-19患者由来の血液細胞における遺伝子発現の網羅的解析 --重症度に応じた遺伝子発現の変化には、ヒトゲノム配列の個人差が影響する--. 京都大学プレスリリース. 2022-08-23.Coronavirus disease 2019 (COVID-19) is a recently-emerged infectious disease that has caused millions of deaths, where comprehensive understanding of disease mechanisms is still unestablished. In particular, studies of gene expression dynamics and regulation landscape in COVID-19 infected individuals are limited. Here, we report on a thorough analysis of whole blood RNA-seq data from 465 genotyped samples from the Japan COVID-19 Task Force, including 359 severe and 106 non-severe COVID-19 cases. We discover 1169 putative causal expression quantitative trait loci (eQTLs) including 34 possible colocalizations with biobank fine-mapping results of hematopoietic traits in a Japanese population, 1549 putative causal splice QTLs (sQTLs; e.g. two independent sQTLs at TOR1AIP1), as well as biologically interpretable trans-eQTL examples (e.g., REST and STING1), all fine-mapped at single variant resolution. We perform differential gene expression analysis to elucidate 198 genes with increased expression in severe COVID-19 cases and enriched for innate immune-related functions. Finally, we evaluate the limited but non-zero effect of COVID-19 phenotype on eQTL discovery, and highlight the presence of COVID-19 severity-interaction eQTLs (ieQTLs; e.g., CLEC4C and MYBL2). Our study provides a comprehensive catalog of whole blood regulatory variants in Japanese, as well as a reference for transcriptional landscapes in response to COVID-19 infection

DOCK2 is involved in the host genetics and biology of severe COVID-19

「コロナ制圧タスクフォース」COVID-19疾患感受性遺伝子DOCK2の重症化機序を解明 --アジア最大のバイオレポジトリーでCOVID-19の治療標的を発見--. 京都大学プレスリリース. 2022-08-10.Identifying the host genetic factors underlying severe COVID-19 is an emerging challenge. Here we conducted a genome-wide association study (GWAS) involving 2, 393 cases of COVID-19 in a cohort of Japanese individuals collected during the initial waves of the pandemic, with 3, 289 unaffected controls. We identified a variant on chromosome 5 at 5q35 (rs60200309-A), close to the dedicator of cytokinesis 2 gene (DOCK2), which was associated with severe COVID-19 in patients less than 65 years of age. This risk allele was prevalent in East Asian individuals but rare in Europeans, highlighting the value of genome-wide association studies in non-European populations. RNA-sequencing analysis of 473 bulk peripheral blood samples identified decreased expression of DOCK2 associated with the risk allele in these younger patients. DOCK2 expression was suppressed in patients with severe cases of COVID-19. Single-cell RNA-sequencing analysis (n = 61 individuals) identified cell-type-specific downregulation of DOCK2 and a COVID-19-specific decreasing effect of the risk allele on DOCK2 expression in non-classical monocytes. Immunohistochemistry of lung specimens from patients with severe COVID-19 pneumonia showed suppressed DOCK2 expression. Moreover, inhibition of DOCK2 function with CPYPP increased the severity of pneumonia in a Syrian hamster model of SARS-CoV-2 infection, characterized by weight loss, lung oedema, enhanced viral loads, impaired macrophage recruitment and dysregulated type I interferon responses. We conclude that DOCK2 has an important role in the host immune response to SARS-CoV-2 infection and the development of severe COVID-19, and could be further explored as a potential biomarker and/or therapeutic target