Kaplan-Meier analysis for cardiovascular disease survival by sexual interest.

(A) males, (B) females.</p

Kaplan-Meier analysis for overall survival by sexual interest.

(A) males, (B) females.</p

Characteristics of study subjects.

Characteristics of study subjects.</p

Kaplan-Meier analysis for cancer survival by sexual interest.

(A) males, (B) females.</p

Serum expression of miRNAs in patients with pancreatic diseases.

<p>Scatter plots of serum miRNA expression in AIP (n = 15), IPMN (n = 26) and PDAC patients (n = 69). The Y-axis represents the relative expression of the miRNAs normalized to cel-miR-39. The line represents the median value. The significance of differences was determined using Mann-Whitney test (***P < .001: **P < .01). (A) miR-7 expression. (B) miR-34a expression. (C) miR-181d expression. (D) miR-193b expression. AIP, autoimmune pancreatitis; IPMN, intraductal papillary mucinous neoplasm; PDAC, pancreatic ductal adenocarcinoma.</p

Receiver operating characteristic curve analysis using serum microRNAs ((A) miR-7, (B) miR-34a, (C) miR-181d, (D) miR-193b) for distinguishing PDAC from AIP.

<p>Receiver operating characteristic curve analysis using serum microRNAs ((A) miR-7, (B) miR-34a, (C) miR-181d, (D) miR-193b) for distinguishing PDAC from AIP.</p

High Serum Adiponectin Level Is a Risk Factor for Anemia in Japanese Men: A Prospective Observational Study of 1,029 Japanese Subjects

<div><p>Erythroid abnormalities including anemia and polycythemia are often observed in the general clinical setting. Because recent studies reported that adiponectin negatively affects hematopoiesis, we performed a prospective observational study to assess the relationship between anemia and adiponectin, as well as other parameters, in 1029 Japanese subjects (477 men and 552 women) 40 years of age and older. Body measurements, blood tests, and nutrition intake studies were performed at baseline, and 5 to 7 years later (follow-up). Hemoglobin (Hb) and hematocrit (Hct) levels in men with high serum adiponectin levels were lower at follow-up than at baseline. Multiple regression analysis showed that age, body mass index, adiponectin, and glutamic-pyruvic transaminase were significantly associated with erythroid-related variables (red blood cells, Hb, and Hct) in both men and women (P <0.05). In a logistic regression analysis, adiponectin, fasting blood glucose, and β-natriuretic peptide were significant risk factors for anemia in men, and blood urea nitrogen and amylase were significant risk factors in women. Physical features and nutrient intake were not risk factors for anemia. Our study demonstrates, both clinically and epidemiologically, that a high serum adiponectin level decreases the amounts of erythroid-related variables and is a risk factor for anemia in Japanese men.</p></div