Social Distance Evaluation in Human Parietal Cortex

Across cultures, social relationships are often thought of, described, and acted out in terms of physical space (e.g. “close friends” “high lord”). Does this cognitive mapping of social concepts arise from shared brain resources for processing social and physical relationships? Using fMRI, we found that the tasks of evaluating social compatibility and of evaluating physical distances engage a common brain substrate in the parietal cortex. The present study shows the possibility of an analytic brain mechanism to process and represent complex networks of social relationships. Given parietal cortex's known role in constructing egocentric maps of physical space, our present findings may help to explain the linguistic, psychological and behavioural links between social and physical space

RS3PE syndrome with subsequent PMR caused by long-term DPP-4 inhibitor use

Remitting seronegative symmetrical synovitis with pitting oedema (RS3PE) syndrome has been reported in patients treated with dipeptidyl peptidase-4 inhibitors (DPP-4i). We experienced a case of RS3PE syndrome in a 73-year-old man with a history of type 2 diabetes, who developed RS3PE as a side effect of vildagliptin. Further to this, the patient developed polymyalgia rheumatica (PMR), the first such case associated with long-term DPP-4i use

The Second Survey of the Molecular Clouds in the Large Magellanic Cloud by NANTEN I: Catalog of Molecular Clouds

The second survey of the molecular clouds in 12CO (J = 1-0) was carried out in the Large Magellanic Cloud by NANTEN. The sensitivity of this survey is twice as high as that of the previous NANTEN survey, leading to a detection of molecular clouds with M_CO > 2 x 10^4 M_sun. We identified 272 molecular clouds, 230 of which are detected at three or more observed positions. We derived the physical properties, such as size, line width, virial mass, of the 164 GMCs which have an extent more than the beam size of NANTEN in both the major and minor axes. The CO luminosity and virial mass of the clouds show a good correlation of M_VIR propto L_CO^{1.1 +- 0.1} with a Spearman rank correlation of 0.8 suggesting that the clouds are in nearly virial equilibrium. Assuming the clouds are in virial equilibrium, we derived an X_CO-factor to be ~ 7 x 10^20 cm^-2 (K km s^-1)^-1. The mass spectrum of the clouds is fitted well by a power law of N_cloud(>M_CO) proportional to M_CO^{-0.75 +- 0.06} above the completeness limit of 5 x 10^4 M_sun. The slope of the mass spectrum becomes steeper if we fit only the massive clouds; e.g., N_cloud (>M_CO) is proportional to M_CO^{-1.2 +- 0.2} for M_CO > 3 x 10^5 M_sun.Comment: 54 pages in total, 18 figures (21 files) and 4 tables, to appear in Astrophysical Journal Supplement Series. A full color version with higher resolution figures is available at http://www.a.phys.nagoya-u.ac.jp/~kawamura/research/NANTEN_LMC_1_preprint_highres.pd

High-Mass Cloud Cores in the eta Carinae Giant Molecular Cloud

We carried out an unbiased survey for massive dense cores in the giant molecular cloud associated with eta Carinae with the NANTEN telescope in 12CO, 13CO, and C18O 1-0 emission lines. We identified 15 C18O cores. Two of the 15 cores are associated with IRAS point sources whose luminosities are larger than 10^4 Lo, which indicates that massive star formation is occuring within these cores. Five cores including the two with IRAS sources are associated with MSX point sources. We detected H13CO+ (1-0) emission toward 4 C18O cores, one of which is associated with neither IRAS nor MSX point sources. This core shows the presence of a bipolar molecular outflow in 12CO (2-1), which indicates that star formation is also occuring in the core. In total, six C18O cores out of 15 are experienced star formation, and at least 2 of 15 are massive-star forming cores in the eta Car GMC. We found that massive star formation occurs preferentially in cores with larger column density, mass, number density, and smaller ratio of virial mass to LTE mass Mvir/M. We also found that the cores in the eta Car GMC are characterized by large line width and Mvir/M on average compared to the cores in other GMCs. We investigated the origin of a large amount of turbulence in the eta Car GMC. We propose the possibility that the large turbulence was pre-existing when the GMC was formed, and is now dissipating. Mechanisms such as multiple supernova explosions in the Carina flare supershell may have contributed to form a GMC with a large amount of turbulence.Comment: 41 pages, including 11 fugures and 9 tables. Accepted by ApJ. Author changed. Paper with high resolution figures is available at http://astrol.cias.osakafu-u.ac.jp/~yonekura/work/paper/etaCar

Global Biobank analyses provide lessons for developing polygenic risk scores across diverse cohorts

Polygenic risk scores (PRSs) have been widely explored in precision medicine. However, few studies have thoroughly investigated their best practices in global populations across different diseases. We here utilized data from Global Biobank Meta-analysis Initiative (GBMI) to explore methodological considerations and PRS performance in 9 different biobanks for 14 disease endpoints. Specifically, we constructed PRSs using pruning and thresholding (P + T) and PRS-continuous shrinkage (CS). For both methods, using a European-based linkage disequilibrium (LD) reference panel resulted in comparable or higher prediction accuracy compared with several other non-European-based panels. PRS-CS overall outperformed the classic P + T method, especially for endpoints with higher SNP-based heritability. Notably, prediction accuracy is heterogeneous across endpoints, biobanks, and ancestries, especially for asthma, which has known variation in disease prevalence across populations. Overall, we provide lessons for PRS construction, evaluation, and interpretation using GBMI resources and highlight the importance of best practices for PRS in the biobank-scale genomics era.</p

Development of Flight Slit-Jaw Optics for Chromospheric Lyman-Alpha SpectroPolarimeter

In sounding rocket experiment CLASP, I have placed a slit a mirror-finished around the focal point of the telescope. The light reflected by the mirror surface surrounding the slit is then imaged in Slit-jaw optical system, to obtain the a-ray Lyman secondary image. This image, not only to use the real-time image in rocket flight rocket oriented direction selection, and also used as a scientific data showing the spatial structure of the Lyman alpha emission line intensity distribution and solar chromosphere around the observation area of the polarimetric spectroscope. Slit-jaw optical system is a two off-axis mirror unit part including a parabolic mirror and folding mirror, Lyman alpha transmission filter, the optical system magnification 1x consisting camera. The camera is supplied from the United States, and the other was carried out fabrication and testing in all the Japanese side. Slit-jaw optical system, it is difficult to access the structure, it is necessary to install the low place clearance. Therefore, influence the optical performance, the fine adjustment is necessary optical elements are collectively in the form of the mirror unit. On the other hand, due to the alignment of the solar sensor in the US launch site, must be removed once the Lyman alpha transmission filter holder including a filter has a different part from the mirror unit. In order to make the structure simple, stray light measures Aru to concentrate around Lyman alpha transmission filter. To overcome the difficulties of performing optical alignment in Lyman alpha wavelength absorbed by the atmosphere, it was planned 'following four steps in order to reduce standing time alignment me. 1. is measured in advance refractive index at Lyman alpha wavelength of Lyman alpha transmission filter (121.567nm), to prepare a visible light Firuwo having the same optical path length in the visible light (630nm).2. The mirror structure CLASP before mounting unit standing, dummy slit and camera standing prescribed position in leading frame is, to complete the internal alignment adjustment. 3. CLASP structure F mirror unit and by attaching the visible light filter, as will plague the focus is carried out in standing position adjustment visible flight products camera. 4. Replace the Lyman alpha transmission filter, it is confirmed by Lyman alpha wavelength (under vacuum) the requested optical performance have come. Currently, up to 3 of the steps completed, it was confirmed in the visible light optical performance that satisfies the required value sufficiently extended. Also, put in Slit-jaw optical system the sunlight through the telescope of CLASP, it is also confirmed that and that stray light rejection no vignetting is in the field of view meets request standing

Development of Flight Slit-Jaw Optics for Chromospheric Lyman-Alpha SpectroPolarimeter

In sounding rocket experiment CLASP, I have placed a slit a mirrorfinished around the focal point of the telescope. The light reflected by the mirror surface surrounding the slit is then imaged in Slitjaw optical system, to obtain the alpharay Lyman secondary image. This image, not only to use the realtime image in rocket flight rocket oriented direction selection, and also used as a scientific data showing the spatial structure of the Lyman alpha emission line intensity distribution and solar chromosphere around the observation area of the polarimetric spectroscope. Slitjaw optical system is a two offaxis mirror unit part including a parabolic mirror and folding mirror, Lyman alpha transmission filter, the optical system magnification 1x consisting camera. The camera is supplied from the United States, and the other was carried out fabrication and testing in all the Japanese side. Slitjaw optical system, it is difficult to access the structure, it is necessary to install the low place clearance. Therefore, influence the optical performance, the fine adjustment is necessary optical elements are collectively in the form of the mirror unit. On the other hand, due to the alignment of the solar sensor in the US launch site, must be removed once the Lyman alpha transmission filter holder including a filter has a different part from the mirror unit. In order to make the structure simple, stray light measures Aru to concentrate around Lyman alpha transmission filter. To overcome the difficulties of performing optical alignment in Lyman alpha wavelength absorbed by the atmosphere, it was planned following four steps in order to reduce standing time alignment me. 1: is measured in advance refractive index at Lyman alpha wavelength of Lyman alpha transmission filter (121.567nm), to prepare a visible light Firuwo having the same optical path length in the visible light (630nm). 2: The mirror structure CLASP before mounting unit standing, dummy slit and camera standing prescribed position in leading frame is, to complete the internal alignment adjustment. 3: CLASP structure F mirror unit and by attaching the visible light filter, as will plague the focus is carried out in standing position adjustment visible flight products camera. 4: Replace the Lyman alpha transmission filter, it is confirmed by Lyman alpha wavelength (under vacuum) the requested optical performance have come. Currently, up to 3 of the steps completed, it was confirmed in the visible light optical performance that satisfies the required value sufficiently extended. Also, put in Slitjaw optical system the sunlight through the telescope of CLASP, it is also confirmed that and that stray light rejection no vignetting is in the field of view meets request standing