Large Mass Scale by Strong Gauge Dynamics with Infrared Fixed Point

We consider a mechanism for realizing the desired decoupling of strongly-coupled sector which is supposed to generate hierarchical structure of the Yukawa couplings. In our mechanism, the same strongly-coupled sector is responsible for generating a sufficiently flat potential and a large vacuum expectation value (VEV) of a gauge-singlet scalar field by suppressing its soft scalar mass and self-coupling. Vacuum instability is caused by supersymmetry-breaking A-term of order 10 TeV. We explicitly demonstrate the infrared convergence of soft scalar masses due to strongly-coupled dynamics and show the soft mass of the singlet is at most comparable to soft masses of squarks and sleptons, which are much suppressed than the A-term. The physical mass scale of the decoupling is calculated in a self-consistent way. We also reinterpret the result in terms of a RG-improved effective potential.Comment: 18 pages, 4 figures, 1 table, LaTeX (PTPTeX style

MR head reading characteristics in perpendicular magnetic recording

科研費報告書収録論文(課題番号:07405052・基盤研究(A)(2)・H7～H9/研究代表者:中村, 慶久/テラビット・スピニック・データストレージの基礎検討

Comparison between Cases of Total Hip Arthroplasty Followed by Colonna Capsular Arthroplasty and Lorenz Cast Reduction in Patients with Developmental Dysplasia of the Hip

Most patients with developmental dysplasia of the hip (DDH) now receive closed-reduction treatment within 6 months after birth. The long-term outcomes of patients with late-detection DDH have remained unclear. We reviewed the clinical records of 18 patients who underwent Colonna capsular arthroplasty (n=8) or closed reduction (n=10) for developmental dysplasia of the hip as infants or young children and underwent total hip arthroplasty approximately in midlife. Both the Colonna capsular arthroplasty and closed reduction groups achieved good clinical results after total hip arthroplasty. However, the operating time was longer and the improvements of hip range of motion and clinical score were significantly worse in the Colonna capsular arthroplasty group than in the closed reduction group

Molecular cloning and functional expression of a novel brain-specific inward rectifier potassium channel

AbstractWe have cloned a novel brain-specific inward rectifier K+ channel from a mouse brain cDNA library and designated it MB-IRK3. The mouse brain cDNA library was screened using a fragment of the mouse macrophage inward rectifier K+ channel (IRK1) cDNA as a probe. The amino acid sequence of MB-IRK3 shares 61% and 64% identity to MB-IRK1 and RB-IRK2, respectively.Xenopus oocytes injected with cRNA derived from this clone expressed a potassium current which showed inward-rectifying channel characteristics similar to MB-IRK1 and RB-IRK2 currents, but distinct from ROMK1 or GIRK1 current. However, the single channel conductance of MB-IRK3 was ∼ 10 pS with 140 mM extracellular K+, which was distinct from that of MB-IRK1 (20 pS). MB-IRK3 mRNA expressed specifically in the forebrain, which clearly differed from MB-IRK1 and RB-IRK2 mRNAs. These results indicate that members of the IRK family with distinct electrophysiological properties express differentially and may play heterogenous functional roles in brain functions

Development of workshop framework empowering local stakeholders for “place strategy” in a district: An implementation at Omotesando, Tokyo

This research aims to structure the workshop framework ‘empowering local stakeholders to create a “place strategy”’, a spatial planning and management strategy for enhancing place function in a district. This strategy primarily focuses on the team-up phase for stakeholders with human and financial resources, whose mission is to bridge a backcasting vision to the next step involving others and users of the streets. Referring to the ‘link and place’ theory, originally developed in England and adapted to fit the alternative plans suggested by municipal officials at the community level, the paper establishes a toolkit and sessions for the conduct of a community-led workshop in Japan. The prototype workshop was implemented for the place strategy of Omotesando, a mixed land-use district with a famous shopping avenue in Tokyo. The validity of the workshop was examined based on opinion changes and the feedback of participants at each session. The results show that the prototype can draw the participant's consciousness on both the link and place functions, including a perspective on effective bus service. The policy option guides affected the participants' choice of flexible tactics by illustrating the relationship of link and place, which is not necessarily a trade-off

Peroxisome proliferator-activated receptor δ as a molecular target to regulate lung cancer cell growth

AbstractIt has been assumed that prostaglandin (PG)I2 signaling contributes to the negative growth control of lung cancer cells; however, the mechanism remains unresolved. PGI2 functions through a cell surface G protein-coupled receptor (prostaglandin I2-binding receptor, IP) and also exerts an effect by interacting with a nuclear hormone receptor, peroxisome proliferator-activated receptor δ (PPARδ). We found that PPARδ was a key molecule of PGI2 signaling to give negative growth control of lung cancer cells (A549), using carbarprostacyclin, a PGI2 agonist for IP and PPARδ, and L-165041, a PPARδ agonist. Furthermore, PPARδ-induced cell growth control was reinforced by the inhibition of cyclooxygenase. These results suggest that PPARδ activation under the suppression of PG synthesis is important to regulate lung cancer cell growth

RETINAL BLOOD FLOW LEVELS MEASURED BY LASER SPECKLE FLOWGRAPHY IN PATIENTS WHO RECEIVED INTRAVITREAL BEVACIZUMAB INJECTION FOR MACULAR EDEMA SECONDARY TO CENTRAL RETINAL VEIN OCCLUSION

Purpose: To report retinal blood flow levels measured by Laser speckle flowgraphy in three patients after they received an intravitreal bevacizumab injection (IVB) for macular edema secondary to central retinal vein occlusion (CRVO). Methods: Three patients (3 eyes) being treated with IVB (1.25 mg/0.05 mL) for secondary macular edema of CRVO were examined. Laser speckle flowgraphy analyses of the blood flow were based on the examinations of mean blur rate (MBR) at the major vessels of the optic disk. Central retinal thickness (CRT) was measured by optical coherence tomography using Macular Cube 512 128 scanning protocol. Results: After the first IVB, Case 1 exhibited an increase in MBR and decrease in CRT. After 4months, an additional injectionwas required because of a subsequentMBR decrease and CRT increase, which led to an increase inMBR and decrease in CRT similar to that observed after the first treatment. Subsequently, blood flow has continued to improve without additional IVB. Macular edema recurrence in Case 2 led to 3 further IVBs over a 6-month period. Although increases inMBRanddecreases inCRTwerenoted,MBRvalues tendedtodeclineafter eachIVB. In Case 3, macular edema recurrence led to 5 additional IVBs being carried out within a 1-year period. Continuous MBR increases and CRT decreases were observed in the patient after each IVB. By measuringMBR using laser speckle flowgraphy,wemay predict the prognosis of CRVO. Conclusion: Mean blur rate increases after IVB were confirmed by laser speckle flowgraphy in three patients. Even though CRVO pathology backgrounds can vary, laser speckle flowgraphy may be useful in both determining the CRVO prognosis and in evaluating treatment efficacy

Preparation and Characterization of Human Recombinant Protein 1/Clara Cell Mr 10 000 Protein

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