Decreased levels of insulin-like growth factor-1 and vascular endothelial growth factor relevant to the ossification disturbance in femoral heads spontaneous hypertensive rats.

Ossification disturbance in femoral head reportedly is seen in the Spontaneously Hypertensive rats (SHR) between ages of 10 and 20 weeks. We investigated serum and tissue levels of insulin-like growth factor-1 (IGF-1) and vascular endothelial growth factor (VEGF) in SHR relevant to the ossification disturbance and osteonecrosis of the femoral head. Serum levels of IGF-1 and VEGF were significantly lower in SHR than in Wistar Kyoto rats (WKY) at weeks 5, 10, 15 and 20 (p<0.005). The incidence of histological ossification disturbance of the femoral head was higher in SHR (59%) than in WKY (40%) at week 20. Lower serum and local levels of VEGF in SHR appeared to be related to the incomplete ossification of the femoral heads. Immunohistochemical study showed significantly lower numbers of IGF-1 and VEGF positive chondrocytes in the femoral epiphyseal cartilage of SHR than in those of WKY at weeks 10, 15 and 20. Our results suggest that local and/or systemic levels of IGF-1 and VEGF between ages of 5 and 20 weeks might play roles in the pathogenesis of ossifi cation disturbance of the femoral head in SHR

粒子-ガンマ線相関を用いた重イオン共鳴の分子的構造の分析

Particle-particle-gamma data from 28Si+28Si molecular resonances was analised. By using R-matrix scattering amplitudes from high-spin molecular model, we can theoretically calculate gamma-ray intensities from the fragments 28Si which are emitted from the resonance decays. The experimental data suggest "m = 0" which means the spins vectors of 28Si are on the reaction plane. We studied what molecular normal modes exibits such a special nuclear structure. Following mechanism has been expected to obtain the spins parallel to the plane; 1. the stable configuration of 28Si + 28Si is expected to be an equator-equator touching configuration, 2. such a stable configuration has a tri-axial deformation, 3. due to extremely high spin rotation(J=38), the total deformed object rotates around the axis of highest moments of inertia, which give rise to K-mixing so called wobbling mode. Then the symmetry axes of two 28Si are perpendicular to the plane, and the spin vectors are on the plane because they are orthogonal to the axes. Such a rotational mode is possible for the molecular ground state and the butterfly and anti-butterfly modes. We have also another mode twisting to obtain non-alignments by simpler mechanism, in which two 28Si spin around the molecular axis in the opposite spin-vector directions. The vectors are parallel to the molecular axis which rotates on the reaction plane. Comparing theoretical results with the data, we conclude that the molecular ground state with wobbling rotation is a candidate for the resonance structure. The other two are not good candidates by the following reason. In the butterfly mode and the twisting one the spin vcctors are parallel to the fragment direction and the beam one, respectively. Even with the spins parallel to the reaction plane, we obtained no "m = 0" from too much concentrated vectors to own directions, because "m = 0" require" symmetry around z-axis"

粒子-ガンマ線相関を用いた重イオン共鳴の分子的構造の分析

Particle-particle-gamma data from 28Si+28Si molecular resonances was analised. By using R-matrix scattering amplitudes from high-spin molecular model, we can theoretically calculate gamma-ray intensities from the fragments 28Si which are emitted from the resonance decays. The experimental data suggest "m = 0" which means the spins vectors of 28Si are on the reaction plane. We studied what molecular normal modes exibits such a special nuclear structure. Following mechanism has been expected to obtain the spins parallel to the plane; 1. the stable configuration of 28Si + 28Si is expected to be an equator-equator touching configuration, 2. such a stable configuration has a tri-axial deformation, 3. due to extremely high spin rotation(J=38), the total deformed object rotates around the axis of highest moments of inertia, which give rise to K-mixing so called wobbling mode. Then the symmetry axes of two 28Si are perpendicular to the plane, and the spin vectors are on the plane because they are orthogonal to the axes. Such a rotational mode is possible for the molecular ground state and the butterfly and anti-butterfly modes. We have also another mode twisting to obtain non-alignments by simpler mechanism, in which two 28Si spin around the molecular axis in the opposite spin-vector directions. The vectors are parallel to the molecular axis which rotates on the reaction plane. Comparing theoretical results with the data, we conclude that the molecular ground state with wobbling rotation is a candidate for the resonance structure. The other two are not good candidates by the following reason. In the butterfly mode and the twisting one the spin vcctors are parallel to the fragment direction and the beam one, respectively. Even with the spins parallel to the reaction plane, we obtained no "m = 0" from too much concentrated vectors to own directions, because "m = 0" require" symmetry around z-axis"

Tsunami field survey of the 1992 Nicaragua earthquake

Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/95368/1/eost9614.pd

Phylogeography of Juniperus Species (Cupressaceae) with a Disjunct Distribution in the Island Areas of Japan

departmental bulletin pape