32 research outputs found
Integrated education of gross anatomy and CT radiology for current advances in medicine
It is essential to learn human anatomy in 3D for advanced medicine. We designed such
an education system by integrating anatomy dissection with diagnostic CT radiology.
Cadavers were scanned by CT, and students consulted the postmortem CT images while
dissecting the cadaver to gain a better understanding of 3D human anatomy and
diagnostic radiology. Students used handheld DICOM viewers at the bench-side (OsiriX
on iPod touch). Students had lectures and workshops on diagnostic radiology, and study
assignments where they discussed findings in anatomy labs in comparison with CT
radiology. This teaching method for gross anatomy was used from 2009, and yielded
positive students’ perspectives, and significant improvements in radiology skills at
clinical courses.This is the pre-peer reviewed version of the
following article: Tohru Murakami, Yuki Tajika,
Hitoshi Ueno, Sachiko Awata, Satoshi
Hirasawa, Maki Sugimoto, Yoshihiko Kominato,
Yoshito Tsushima, Keigo Endo, and Hiroshi
Yorifuji. An integrated teaching method of gross
anatomy and computed tomography radiology.
Anat Sci Educ, 2014, which has been published
in final form at http://onlinelibrary.wiley.com/
doi/10.1002/ase.1430/abstract
Replication study of the association of SNPs in the LHX3-QSOX2 and IGF1 loci with adult height in the Japanese population; wide-ranging comparison of each SNP genotype distribution
Adult height is a highly heritable trait involving multiple genes. Recent genome-wide association studies have identified that SNP rs12338076 in the LHX3-QSOX2 locus, and rs1457595 and rs17032362 in the IGF1 locus are associated with human height in the Japanese population (Okada et al. (2010)[9]). We performed a replication study to examine the associations between these three SNPs and adult height in the Japanese population based on autopsy cases. However, it was not possible to confirm that all these SNPs influenced adult height in the study population. We first conducted a wide-ranging survey of these three SNPs in the above genes using nine different populations including Asians, Africans and Caucasians, and demonstrated that the genotypes of rs12338076 and rs17032362 were distributed in an ethnicity-dependent manner; even within Asian populations, the genotype distributions of the SNPs differed widely. Although there are differences in height distribution between different populations, possibly due to genetic factors and/or gene-environmental interactions, the contradictory results of the association study and ethnic differences in genotype distribution allow us to assume that these height-related SNPs in the genes may contribute to adult height to a slight extent, at least in the Japanese population. It is anticipated that the present information will be useful for developing a reliable tool for personal identification through elucidation of the genetic basis of human height