The dwarf phenotype of the Arabidopsis acl5 mutant is suppressed by a mutation in an upstream ORF of a bHLH gene

Loss-of-function mutants of the Arabidopsis thaliana ACAULIS 5 (ACL5) gene, which encodes spermine synthase, exhibit a severe dwarf phenotype. To elucidate the ACL5-mediated regulatory pathways of stem internocle elongation, we isolated four suppressor of acaulis (sac) mutants that reverse the acl5 dwarf phenotype. Because these mutants do not rescue the dwarfism of known phytohormone-related mutants, the SAC genes appear to act specifically on the ACL5 pathways. We identify the gene responsible for the dominant sac51-d mutant, which almost completely suppresses the acl5 phenotype. sac51-d disrupts a short upstream open reading frame (uORF) of SAC51, which encodes a bHLH-type transcription factor. Our results indicate that premature termination of the uORF in sac51-d results in an increase in its own transcript level, probably as a result of an increased translation of the main ORF. We suggest a model in which ACL5 plays a role in the translational activation of SAC51, which may lead to the expression of a subset of genes required for stem elongation

再発転移後の肺がん患者が持つ見通し

This study aimed at clarifying prospects that lung cancer patients undergoing treatment after recurrence and metastasis have. The study method is based on the qualitative descriptive study design. A semi-structured interview was performed for １３ lung cancer patients undergoing treatment after recurrence and metastasis. As a result, the following five categories were extracted［; Since it is recurrence and metastasis, the death is coming to me］［, I am undergoing treatment so I’m alright now but I’ll die someday］［, Let a matter take its own course］［, My life will be going as before］and［I will be living as long as I receive treatment］. Characteristics of the above are that all of the patients are ready to accept death and they had more than two prospects. They were characteristic of patients after recurrence and metastasis that symptoms that remind them of repeated treatment and death appear and there is uncertainty for their future. The above results have suggested the need to capture the state of each prospect while confirming the prospects of lung cancer patients under treatment after recurrence and metastasis

高齢者看護学実習における学生の高齢患者の理解の実態

The purpose of this study was to clarify how the students understand the older patients based on Orem’s nursing theory in Geriatric Nursing Training. The participants were１７nursing students in third grade. The interview was carried out using semi-structured interview with students for how they felt older patients. As a result, two categories were extracted ; ［ they need limited care for deficient parts］and［they have toughness cultivated through their long life］. The students understood the older patients as having self-caring abilities and thought that limited care should be provided only for deficient parts of patients. Also, they understood older patients as having strength cultivated through their long life. It is necessary for teachers to assess the Self-care agency more severely for students to get hold of mature elements characteristic of older patients

Psychological Adjustment in Lung Cancer Patients

The purpose of study was to clarify the psychological adjustment and related factors in lung cancer patients with recurrence/metastasis after curative surgery. Forty-one with lung cancer who were informed of a recurrence/metastasis after curative surgery completed a questionnaire comprised of the Mental Adjustment to Cancer Scale (MAC), Psychological Adjustment scale for Cancer Survivors (PACS), and information pertaining to demographic variables. When healthcare providers intervene in patients with lung cancer that has recurred/metastasized after curative surgery, it is necessary to assess patients’ psychological adjustment based on demographic information, such as age, sex, marital status, and employment status, and to provide effective support promptly. Factors associated with psychological adjustment with recurrent/metastatic lung cancer after curative surgery were 1) female, 2) having a job, 3) over 65 years of age, 4) having a spouse, and 5) advanced-stage cancer. There was no difference in psychological adjustment between treatment and the period from cancer incidence to recurrence/metastatic

Relationship between ceruloplasmin and oxidative biomarkers including ferritin among healthy Japanese

Serum ceruloplasmin (CP), a marker relevant to copper metabolism, is one of famous inflammation markers with a reduction in Wilson's disease, whereas serum ferritin is a marker relevant to iron metabolism. Recently, ferritin is pointed out to be related with oxidative stress. However, there is still no population research which showed the relation of CP and ferritin. Therefore, we investigated the relationship between CP and ferritin including oxidative stress biomarkers among healthy Japanese (n = 389). We measured serum CP, ferritin, Fe, high-sensitivity C-reactive protein (hs-CRP), and urinary oxidative stress biomarkers [H2O2, 8-hydroxy-2'-deoxyguanosine (8-OHdG), 8-isoprostane] and so on. Subjects showed that age; 41.7 ± 10.0 (year), CP; 31.9 ± 6.8 (mg/dl), ferritin; 123.5 ± 121.0 (ng/ml), hs-CRP; 0.89 ± 2.53 (mg/l), 8-OHdG; 10.2 ± 4.4 [ng/mg creatinine (Cre)] and H2O2; 6.5 ± 10.9 (µM/g Cre), (All data mentioned above were expressed as mean ± SD). CP was significantly and positively correlated with hs-CRP and inversely correlated with ferritin, Fe and 8-OHdG. By a multiple logistic regression analysis, odds ratio of CP according to quartiles of hs-CRP was 4.86, and according to quartiles of 8-OHdG was 0.39 after adjusting for age and other confounding factors. In conclusion, our findings suggest that CP was an antioxidative biomarker which controls oxidative stress, whereas ferritin was a marker which may participate in the generation of oxidative stress

看護学生が理解するパワー構成要素

The purpose of this study was to analyze trends in nursing students' assessments of the 10 powers of self-care agency in Gerontological Nursing and to identify educational support for students. The subjects were the practice records of 66 third-year nursing students who completed Gerontological Nursing from September 2019 to February 2020. The results showed that they had a perspective of directing their attention to the patient's interest, will, motivation, and reasoning among 10 power items that all students were able to assess, and that they approached their care with a respectful attitude toward the patient's perceptions and intentions for self-care. In addition, it could be inferred that they understood self-care in terms of patients' behaviors and activities by appearance. Conversely, from the items that more than half of the students were unable to assess, it could be inferred that they were unable to assess how to apply self-care agency to the patient's prospect and lives in future

Present status of home health nursing in a Japanese hospital-based home health care agency

病院を基盤とした在宅看護提供機関における在宅看護の現状を調査し,在宅看護の現在の問題点を明らかにするとともに,在宅看護に携わる看護婦の役割について検討した｡本調査の結果,一人暮らしの患者は,家族に介護者のいる患者に比べ明らかにADLが高い場合も訪問看護を受けていることが分かった｡また,高齢者夫婦二人暮らしの患者と2世代以上家族の患者のADLに差はなく,このことは,高齢の介護者に相当の負担がかかっていると言える｡訪問看護内容としては, 日常生活自立度の低い患者への日常生活援助の実施率は高く,精神的支援や指導的看護技術の実施率は低かった｡在宅看護に携わる看護婦は, 日常生活援助に追われがちであるが,一次予防に焦点を当てたケア,患者や介護者の精神的支援,指導,ケアマネジメントを行うことは緊急の課題である｡We investigated the present status of home health nursing in a Japanese hospital-based home health care agency, to clarify present problems in home health nursing and to assess the roles of home health nurses. Based on our results, ADL of care recipients who lived alone were clearly independent compared with care recipients who lived with family care-givers. The level of ADL of both care recipients who lived with their spouses and those who lived with more than 2 family members were not different. It indicates that aged family care-givers assume great responsibility. In cases of bedridden recipients,daily life care was performed at a high rate, but mental care or teaching care was performed at a low rate. Home health nurses should focus on primary preventive care, mental care for recipients and care-givers, and teaching care or management of a care plan

がん患者を支援する訪問看護師の困難感

This study aimed to identify difficulties of visiting nurses who provide assistance to home-based cancer patients requiring palliative care. In survey１, a questionnaire survey was conducted involving３０visiting nurses working for visiting nursing stations（valid response rate :９０％）, and the data were analyzed using descriptive statistics. In survey ２, a semi-structured interview based on an interview guide was conducted involving４visiting nurses working for visiting nursing stations, and the data were analyzed using a qualitative and inductive approach. The results of survey１showed that the visiting nurses were more likely to experience difficulties with the worsening of a patient’s health status and at the initiation of home-based care. They also experienced difficulties with understanding medical conditions of patients and their families, supporting decision-making, and cooperating with visiting physicians. Their level of understanding about the explanation given by physicians and the sense of value of patients and families were factors that affected such difficulties, and so, in order to resolve them, the importance of cooperating to secure medical and nursing personnel and creating a setting where they can share their knowledge of patients’ conditions and treatments was indicated. In survey ２, the following ６ categories were extracted as difficulties encountered by visiting nurses providing assistance to home-based cancer patients requiring palliative care :［dealing with the worsening of the disease］, ［predicting the end of life］, ［being unable to care for patients without cooperation］,［being involved with patients by understanding their life before illness］,［preparing a home care environment for a patient’s end-of-life］, and［limits of current work situations］. The findings suggest the need not only to provide palliative care knowledge for the prediction and understanding of illness, but also to establish a system that allows multiple medical providers to assess patients’ conditions, in order to deal with their difficulties