Statistical Analysis of Concussion History and Executive Function

<p>Careful selection of statistical analysis is crucial in concussion research utilizing retrospective self-report. Spurious associations are lost after adjusting for reporting bias. </p

Participant Flow.

<p>Flowchart illustrating application of inclusion and exclusion criteria for the current study.</p

Results of the Linear Mixed Effects Model for Immediate Recall.

<p>Results of the Linear Mixed Effects Model for Immediate Recall.</p

Delayed Recall Practice Effects.

<p>Standardized test scores on the delayed recall condition as a function of visit number, test, and clinical diagnosis. Error bars represent 95% confidence intervals and account for within-subjects variability.</p

Additional file 3: Figure S1. of Dioxins and related environmental contaminants increase TDP-43 levels

Elevation of endogenous TDP-43 is dependent upon AHR expression. Figure S2. The effect on TDP-43 protein levels in the brain of peripheral exposure to AHR agonists is not observed with other disease related proteins. Figure S3. TARDBP promoter is activated by AHR agonism. Figure S4. Click-iT pulse-chase labelling of nascent proteins in differentiated M17 cells. Figure S5. Schematic representation of sense AHRE consensus sites “GCGTG” (red flags) of human CYP1A1 and CYP1B1 AHR responsive genes and the ALS-relevant genes TARDBP, SOD1, PON2, C9ORF72, FUS and ATXN2, assayed for changes in transcript levels in Fig. 2. Green boxes are exons. (PDF 2754 kb

Additional file 1: Table S1. of Dioxins and related environmental contaminants increase TDP-43 levels

(DOCX 36.4 kb

Demographic and exposure characteristics of subject groups.

<p>Demographic and exposure characteristics of subject groups.</p