Characteristics of ocular adnexal extranodal marginal zone B-cell lymphoma (EMZL) patients according to the IgG4-positive plasma cell infiltration.

<p>*Fisher’s exact test.</p><p>^†Mann-Whitney U test.</p><p>IgG4-positive group, ocular adenexal EMZL with IgG4:IgG cell ratio > 40%, and IgG4-positive plasma cells ≥ 50 / HPF; IgG4-negative group, ocular adenexal EMZL with IgG4-positive plasma cells < 50 / HPF or IgG4:IgG cell ratio ≤ 40%; AJCC, American Joint Committee on Cancer classification; LDH, Lactate dehydrogenase; IPI, International Prognostic Index.</p><p>Characteristics of ocular adnexal extranodal marginal zone B-cell lymphoma (EMZL) patients according to the IgG4-positive plasma cell infiltration.</p

Clinicopathologic features of ocular adnexal extranodal marginal zone B-cell lymphoma (EMZL) patients with of IgG4-positive plasma cell infiltration.

<p>*Proposed by American Joint Committee on Cancer¹²</p><p>LF, lymphoid follicle; CR, complete response; PD, progressive disease; PR, partial response; SD, stable disease.</p><p>Clinicopathologic features of ocular adnexal extranodal marginal zone B-cell lymphoma (EMZL) patients with of IgG4-positive plasma cell infiltration.</p

Treatment outcome in ocular adnexal extranodal marginal zone B-cell lymphoma (EMZL) patients according to the IgG4-positive plasma cell infiltration.

<p>*Fisher’s exact test.</p><p>^†Mann-Whitney U test.</p><p>IgG4-positive group, ocular adenexal EMZL with IgG4:IgG cell ratio > 40%, and IgG4-positive plasma cells ≥ 50 / HPF; IgG4-negative group, ocular adenexal EMZL with IgG4-positive plasma cells < 50 / HPF or IgG4:IgG cell ratio ≤ 40%.</p><p>CR, complete response; PD, progressive disease; PR, partial response; SD, stable disease.</p><p>Treatment outcome in ocular adnexal extranodal marginal zone B-cell lymphoma (EMZL) patients according to the IgG4-positive plasma cell infiltration.</p

(A) Computed tomographic image revealing an enlarged lacrimal gland of the left side, with homogenous enhancement.

<p>(B) Histological examination result showing lymphoplasma cell infiltration and background fibrosis (H&E, original magnification ×200). Immunohistochemical staining for (C) IgG and (D) IgG4 (original magnification ×200) showing that most of the IgG-positive cells are positive for IgG4.</p