Cryptanalysis of an e_cient three-party password-based key exchange scheme

AbstractIn order to secure communications between two clients with a trusted server's help in public network environments, a three-party password-based authenticated key exchange (3PAKE) scheme is used to provide the transaction confidentiality and e_ciency. In 2010, Lou-Huang proposed a new simple three-party password-based authenticated key exchange (LH-3PAKE) scheme based on elliptic curve cryptography (ECC). By analysis, Lou-Huang claimed that the proposed LH- 3PAKE scheme is not only secure against various attacks, but also more e_cient than previously proposed 3PAKE schemes. However, this paper demonstrates LH-3PAKE scheme is vulnerable to o_-line password guessing attacks by an attacker

Changes in bone mineral density and trabecular bone score in Graves' disease patients after anti-thyroid therapy

AbstractObjectiveThe purpose of this study was to evaluate changes in bone quantity based on bone mineral density (BMD) and bone quality based on trabecular bone score (TBS) in Graves' disease patients after anti-thyroid therapy.Research design and methodThis retrospective study included premenopausal female and male patients with Graves' disease who received BMD measurement more than two times during treatment. BMD and thyroid function tests with free thyroxine (FT4), total triiodothyronine (T3), thyroid stimulating hormone (TSH), and TSH receptor antibody (TRAb) levels were collected two times during follow-up. TBS was calculated using TBS insight® software (version 2.1) from dual-energy X-ray absorptiometry images.ResultsThirty Graves' disease patients (17 males, 56%; 13 premenopausal females, 44%) with a mean age of 35.3 ± 9.9 years were included. The mean follow-up period was 20.7 ± 8.5 months. The median levels of FT4, TSH and TRAb improved at follow-up [2.55 ng/dL (Interquartile range (IQR) 2.07–3.78) to 1.28 ng/dL (IQR 1.23–1.39), 0.015 mIU/L (IQR 0.01–0.04) to 0.89 mIU/L (IQR 0.35–1.55), 17.0 IU/L (IQR 5.0–40.3) to 5.0 IU/L (5.0–6.0), respectively; p < 0.001]. Median BMD (lumbar spine) values also improved from 1.118 g/cm2 (IQR 1.000–1.119) to 1.167 g/cm2 (IQR 1.050–1.219) (p = 0.001) at follow-up. TBS increased from 1.377 (IQR 1.299–1.422) to 1.390 (IQR 1.327–1.430) after treatment (p = 0.038).ConclusionBoth bone quality and density improved after anti-thyroid treatment in premenopausal female and male Graves' disease patients