Music Artist Classification with WaveNet Classifier for Raw Waveform Audio Data

Models for music artist classification usually were operated in the frequency domain, in which the input audio samples are processed by the spectral transformation. The WaveNet architecture, originally designed for speech and music generation. In this paper, we propose an end-to-end architecture in the time domain for this task. A WaveNet classifier was introduced which directly models the features from a raw audio waveform. The WaveNet takes the waveform as the input and several downsampling layers are subsequent to discriminate which artist the input belongs to. In addition, the proposed method is applied to singer identification. The model achieving the best performance obtains an average F1 score of 0.854 on benchmark dataset of Artist20, which is a significant improvement over the related works. In order to show the effectiveness of feature learning of the proposed method, the bottleneck layer of the model is visualized.Comment: 12 page

Three dimension high definition manometry evaluated postoperative anal canal functions in children with congenital anorectal malformations

BackgroundWe aimed to evaluate the function of the reconstructed anal canal in postoperative anorectal malformations (ARMs) patients through three dimension (3D) high-definition anorectal manometry.MethodsFrom January 2015 to December 2019, 3D manometry was performed as a postoperative functional assessment of patients with ARMs divided into age subgroups based on the time of manometry. Manometric parameters, such as the length of the anorectal high-pressure zone (HPZ-length), the mean resting and squeeze pressure of HPZ (HPZ-rest and HPZ-sqze), recto-anal inhibitory reflex (RAIR), and strength distribution of the anal canal, were collected and compared with age-matched controls. Their functional outcomes were analyzed with SPSS 23.0 software for statistical analysis.Results171 manometric measurements were performed on 142 postoperative patients (3 months∼15 years). The HPZ-rest in all patients was significantly lower than in age-matched controls (p < 0.05). HPZ-sqze was notably decreased in patients older than 4 years, whereas other age groups were comparable to controls (p < 0.05). The proportions of asymmetric strength distribution and negative RAIR were higher in ARMs patients. The type of anorectal malformations and lower HPZ-rest were the impact factors affecting postoperative functional outcomes.ConclusionsThe majority of the ARMs patients had acceptable functional outcomes. 3D manometry can objectively assess the reconstructed anal canal function. The patients with fecal incontinence had a high proportion of extremely low HPZ-rest and HPZ-sqze, negative RAIR, and asymmetric strength distribution. The manometric details will help the clinicians explore the causes of defecation complications and guide further management

Solution-processed quasi-two-dimensional perovskite light-emitting diodes using organic small molecular electron transporting layer

In this paper, all-solution-processed LEDs using quasi-two-dimensional perovskites with organic small molecular electron transporting materials (ETMs) are successfully fabricated

CXCR5+PD-1+ follicular helper CD8 T cells control B cell tolerance

Many autoimmune diseases are characterized by the production of autoantibodies. The current view is that CD4+ T follicular helper (Tfh) cells are the main subset regulating autoreactive B cells. Here we report a CXCR5+PD1+ Tfh subset of CD8+ T cells whose development and function are negatively modulated by Stat5. These CD8+ Tfh cells regulate the germinal center B cell response and control autoantibody production, as deficiency of Stat5 in CD8 T cells leads to an increase of CD8+ Tfh cells, resulting in the breakdown of B cell tolerance and concomitant autoantibody production. CD8+ Tfh cells share similar gene signatures with CD4+ Tfh, and require CD40L/CD40 and TCR/MHCI interactions to deliver help to B cells. Our study thus highlights the diversity of follicular T cell subsets that contribute to the breakdown of B-cell tolerance

Large-scale patterned quantum dots as color conversion layer for organic light emitting diode by inkjet printing

In this work, we fabricated 6.6-inch QD display panel by inkjet printing technology, being cooperated with active matrix organic light emitting diodes (AMOLEDs). Here 3-stack blue OLEDs (BOLEDs) with top-emission structure acted as backlight and red QD layer acted as converted materials, which exhibited high quantum efficiency, high luminance, high color purity and improved wide viewing angle of output emission. We believe that inkjet-printed QD display with AMOLEDs would be promising candidate for the next generation display and lighting in the near future