Rhodium-Catalyzed/Copper-Mediated Tandem C(sp²)–H Alkynylation and Annulation: Synthesis of 11-Acylated Imidazo[1,2‑<i>a</i>:3,4‑<i>a</i>′]dipyridin-5-ium-4-olates from 2<i>H</i>‑[1,2′-Bipyridin]-2-ones and Propargyl Alcohols

A rhodium-catalyzed/copper-mediated tandem C­(sp²)–H alkynylation and intramolecular annulation of 2<i>H</i>-[1,2′-bipyridin]-2-ones with propargyl alcohols for the synthesis of 11-acylated imidazo­[1,2-<i>a</i>:3,4-<i>a</i>′]­dipyridin-5-ium-4-olates is described

Hepatoprotective phenylethanoid glycosides from <i>Cirsium setosum</i>

<p>Two new phenylethanoid glycosides, namely <i>β</i>-D-glucopyranoside, 1″-<i>O</i>-(7<i>S</i>)-7-(3-methoxyl-4-hydroxyphenyl)-7-methoxyethyl-3″-<i>α</i>-L-rhamnopyranosyl-4″-[(8<i>E</i>)-7-(3-methoxyl-4-hydroxyphenyl)-8-propenoate] (<b>1</b>) and <i>β</i>-D-glucopyranoside, 1″-<i>O</i>-(7<i>S</i>)-7-(3-methoxyl-4-hydroxyphenyl)-7-methoxyethyl-3″-<i>α</i>-L-rhamnopyranosyl-4″-[(8<i>E</i>)-7-(4-hydroxyphenyl)-8-propenoate] (<b>2</b>), together with six phenylethanoid glycosides were isolated from <i>Cirsium setosum</i>. Their structures were elucidated by their spectroscopic data and references. Compounds <b>2</b>, <b>4</b>, <b>5</b>, <b>7</b> and <b>8</b> (10 μM) exhibited moderate hepatoprotective activities. Compounds (<b>3–8</b>) were obtained from this plant for the first time.</p