Time-Resolved Infrared (TRIR) Studies of Oxycarbonylnitrenes

<i>N</i>-Ethyloxycarbonyl-<i>S</i>,<i>S</i>-dibenzothiphene sulfilimine and <i>N</i>-<i>t</i>-butyloxycarbonyl-<i>S</i>,<i>S</i>-dibenzothiphene sulfilimine have been utilized as precursors to ethoxycarbonylnitrene and <i>t</i>-butyloxycarbonylnitrene. B3LYP/6-31G­(d) calculations predict triplet ground states for both oxycarbonylnitrenes, albeit by small margins. Triplet ethoxycarbonylnitrene and triplet <i>t</i>-butyloxycarbonylnitrene have been observed following photolysis of these sulfilimine precursors by time-resolved infrared (TRIR) spectroscopy. Kinetic studies show that ethoxycarbonylnitrene reacts with solvents such as acetonitrile and cyclohexane, while <i>t</i>-butyloxycarbonylnitrene undergoes an intramolecular insertion reaction to produce 5,5-dimethyl oxazolidinone. Product analysis following photolysis of <i>N</i>-<i>t</i>-butyloxycarbonyl-<i>S</i>,<i>S</i>-dibenzothiphene sulfilimine confirms that the oxazolidinone is the major product with an estimated yield of 90%. The products from these two nitrenes are derived from the corresponding singlet nitrene, either directly or via thermal repopulation of the singlet from the lower-energy triplet nitrene

Association between polymorphisms of the <i>GSDMB</i> gene and allergic rhinitis risk in the Chinese population: a case-control study

Allergic rhinitis (AR) is a great risk factor for developing asthma, and its pathogenesis is affected by various factors, such as gene and environment. GSDMB is related to allergic diseases. Our purpose is to explore the correlation of single nucleotide polymorphisms (SNPs) in GSDMB and AR risk in the Chinese population. We performed a case-control study including 1005 cases and 1004 controls. Rs2305479, rs4795400, and rs12450091 in GSDMB were geneotyped using Agena MassARRAY. The relationships between GSDMB SNPs and AR risk were assessed by logistic regression analysis in PLINK1.9. Our study showed that rs4795400 was a protective factor for AR in overall (TT vs. CC: OR = 0.66, p = 0.009; TT vs. CC/TC: OR = 0.67, p = 0.008; additive: OR = 0.87, p = 0.042 males, people with BMI ≤ 24, and living in wind-blown sand area. Rs2305479 was associated with a reduced AR risk in males (TT vs. CC: OR = 0.47, p = 0.014; TT vs. CC/TC: OR = 0.43, p = 0.004). However, rs12450091 was a risk factor for AR in people living in the loess hilly region (CC: OR = 4.75, p = 0.047). The levels of EO and EO_per in the case group were significantly higher than those in the control group (p  This study indicated that GSDMB polymorphisms (rs4795400, rs2305479, and rs12450091) were associated with AR susceptibility. Further studies are required to confirm our findings and to clarify the functional relationship.</p

Porous Amorphous FePO₄ Nanoparticles Connected by Single-Wall Carbon Nanotubes for Sodium Ion Battery Cathodes

Sodium ion batteries (SIBs) are promising candidates for the applications of large-scale energy storage due to their cost-effective and environmental-friendly characteristics. Nevertheless, it remains a practical challenge to find a cathode material of SIBs showing ideal performance (capacity, reversibility, etc.). We report here a nanocomposite material of amorphous, porous FePO₄ nanoparticles electrically wired by single-wall carbon nanotubes as a potential cathode material for SIBs. The hydrothermally synthesized nanocomposite shows excellent cell performance with unprecedented cycling stability and reversibility. The discharge capacity of as high as 120 mAh/g is delivered at a 0.1 C rate (10 mA/g). The capacity retentions are about 70 mAh/g, 60 mAh/g, and 55 mAh/g at higher currents of 20 mA/g, 40 mA/g, and 60 mA/g, respectively. Even at a 1 C rate (100 mA/g), a capacity of about 50 mAh/g is still retained after 300 cycles. With a simple synthetic procedure, cost-effective chemicals, and desirable cell performance, this method offers a highly promising candidate for commercialized cathode materials of SIBs