Adipose tissue hyaluronan production improves systemic glucose homeostasis and primes adipocytes for CL 316,243-stimulated lipolysis

Plasma hyaluronan (HA) increases systemically in type 2 diabetes (T2D) and the HA synthesis inhibitor, 4-Methylumbelliferone, has been proposed to treat the disease. However, HA is also implicated in normal physiology. Therefore, we generated a Hyaluronan Synthase 2 transgenic mouse line, driven by a tet-response element promoter to understand the role of HA in systemic metabolism. To our surprise, adipocyte-specific overproduction of HA leads to smaller adipocytes and protects mice from high-fat-high-sucrose-diet-induced obesity and glucose intolerance. Adipocytes also have more free glycerol that can be released upon beta3 adrenergic stimulation. Improvements in glucose tolerance were not linked to increased plasma HA. Instead, an HA-driven systemic substrate redistribution and adipose tissue-liver crosstalk contributes to the systemic glucose improvements. In summary, we demonstrate an unexpected improvement in glucose metabolism as a consequence of HA overproduction in adipose tissue, which argues against the use of systemic HA synthesis inhibitors to treat obesity and T2D

Insight-HXMT observations of Swift J0243.6+6124 during its 2017-2018 outburst

The recently discovered neutron star transient Swift J0243.6+6124 has been monitored by {\it the Hard X-ray Modulation Telescope} ({\it Insight-\rm HXMT). Based on the obtained data, we investigate the broadband spectrum of the source throughout the outburst. We estimate the broadband flux of the source and search for possible cyclotron line in the broadband spectrum. No evidence of line-like features is, however, found up to $\rm 150~keV$. In the absence of any cyclotron line in its energy spectrum, we estimate the magnetic field of the source based on the observed spin evolution of the neutron star by applying two accretion torque models. In both cases, we get consistent results with $B\rm \sim 10^{13}~G$, $D\rm \sim 6~kpc$ and peak luminosity of $\rm >10^{39}~erg~s^{-1}$ which makes the source the first Galactic ultraluminous X-ray source hosting a neutron star.Comment: publishe

Overview to the Hard X-ray Modulation Telescope (Insight-HXMT) Satellite

As China's first X-ray astronomical satellite, the Hard X-ray Modulation Telescope (HXMT), which was dubbed as Insight-HXMT after the launch on June 15, 2017, is a wide-band (1-250 keV) slat-collimator-based X-ray astronomy satellite with the capability of all-sky monitoring in 0.2-3 MeV. It was designed to perform pointing, scanning and gamma-ray burst (GRB) observations and, based on the Direct Demodulation Method (DDM), the image of the scanned sky region can be reconstructed. Here we give an overview of the mission and its progresses, including payload, core sciences, ground calibration/facility, ground segment, data archive, software, in-orbit performance, calibration, background model, observations and some preliminary results.Comment: 29 pages, 40 figures, 6 tables, to appear in Sci. China-Phys. Mech. Astron. arXiv admin note: text overlap with arXiv:1910.0443

Potential of Core-Collapse Supernova Neutrino Detection at JUNO

JUNO is an underground neutrino observatory under construction in Jiangmen, China. It uses 20kton liquid scintillator as target, which enables it to detect supernova burst neutrinos of a large statistics for the next galactic core-collapse supernova (CCSN) and also pre-supernova neutrinos from the nearby CCSN progenitors. All flavors of supernova burst neutrinos can be detected by JUNO via several interaction channels, including inverse beta decay, elastic scattering on electron and proton, interactions on C12 nuclei, etc. This retains the possibility for JUNO to reconstruct the energy spectra of supernova burst neutrinos of all flavors. The real time monitoring systems based on FPGA and DAQ are under development in JUNO, which allow prompt alert and trigger-less data acquisition of CCSN events. The alert performances of both monitoring systems have been thoroughly studied using simulations. Moreover, once a CCSN is tagged, the system can give fast characterizations, such as directionality and light curve

Detection of the Diffuse Supernova Neutrino Background with JUNO

As an underground multi-purpose neutrino detector with 20 kton liquid scintillator, Jiangmen Underground Neutrino Observatory (JUNO) is competitive with and complementary to the water-Cherenkov detectors on the search for the diffuse supernova neutrino background (DSNB). Typical supernova models predict 2-4 events per year within the optimal observation window in the JUNO detector. The dominant background is from the neutral-current (NC) interaction of atmospheric neutrinos with 12C nuclei, which surpasses the DSNB by more than one order of magnitude. We evaluated the systematic uncertainty of NC background from the spread of a variety of data-driven models and further developed a method to determine NC background within 15\% with {\it{in}} {\it{situ}} measurements after ten years of running. Besides, the NC-like backgrounds can be effectively suppressed by the intrinsic pulse-shape discrimination (PSD) capabilities of liquid scintillators. In this talk, I will present in detail the improvements on NC background uncertainty evaluation, PSD discriminator development, and finally, the potential of DSNB sensitivity in JUNO

Research on the Identification of Tyre-Road Peak Friction Coefficient under Full Slip Rate Range Based on Normalized Tyre Model

The accurate estimation of the tyre-road peak friction coefficient is the key basis for the normal operation of the vehicle active safety control system. The estimation algorithm needs to be able to adapt to various conditions encountered in the actual driving process of the vehicle and obtain the estimation results timely and accurately. Therefore, a new normalized strategy is proposed in this paper. The core is the equal ratio between the peak friction coefficient and the utilization friction coefficient between adjacent typical roads. This strategy can establish the direct connection (normalization) between tyre force and tyre-road peak friction coefficient through most tyre models in the field of vehicle dynamics and accomplish estimation by combining with the filtering algorithm. In addition, most of the vehicle dynamic estimation algorithms are limited by road excitation, and it is difficult to obtain satisfactory estimation results. This strategy can greatly reduce the system error caused by insufficient road excitation (slip rate is not 0.15–0.20) and improve the applicability of the estimation algorithm to the actual driving process of the vehicle. Finally, the magic formula (MF) tyre model is selected to describe the tyre characteristics after treatment of the normalized strategy; the tyre-road peak friction coefficient is estimated by combining the extended Kalman filter and vehicle dynamics model. Satisfactory estimation results are obtained in both simulation and real vehicle tests, which verifies the effectiveness of the proposed normalized strategy

Integrated Adhesion Coefficient Estimation of 3D Road Surfaces Based on Dimensionless Data-Driven Tire Model

The tire/road peak friction coefficient (TRPFC) is the core parameter of vehicle stability control, and its estimation accuracy significantly affects the control effect of active vehicle safety. To estimate the peak adhesion coefficient accurately, a new method for the comprehensive adhesion coefficient of three-dimensional pavement based on a dimensionless data-driven tire model is proposed. Firstly, in order to accurately describe the contact state between the three-dimensional road surface and the tire during driving, stress distribution and multi-point contact are introduced into the vertical dynamic model and a new tire model driven by dimensionless data is established based on the normalization method. Secondly, the real-time assessment of lateral and longitudinal adhesion coefficients of three-dimensional pavement is realized with the unscented Kalman filter (UKF). Finally, according to the coupling relationship between the longitudinal tire adhesion coefficient and the lateral tire adhesion coefficient, a fuzzy reasoning strategy of fusing the longitudinal tire adhesion coefficient and the lateral tire adhesion coefficient is designed. The results of vehicle tests prove that the method proposed in this paper can estimate the peak adhesion coefficient of pavement quickly and accurately

Integrated Adhesion Coefficient Estimation of 3D Road Surfaces Based on Dimensionless Data-Driven Tire Model

The tire/road peak friction coefficient (TRPFC) is the core parameter of vehicle stability control, and its estimation accuracy significantly affects the control effect of active vehicle safety. To estimate the peak adhesion coefficient accurately, a new method for the comprehensive adhesion coefficient of three-dimensional pavement based on a dimensionless data-driven tire model is proposed. Firstly, in order to accurately describe the contact state between the three-dimensional road surface and the tire during driving, stress distribution and multi-point contact are introduced into the vertical dynamic model and a new tire model driven by dimensionless data is established based on the normalization method. Secondly, the real-time assessment of lateral and longitudinal adhesion coefficients of three-dimensional pavement is realized with the unscented Kalman filter (UKF). Finally, according to the coupling relationship between the longitudinal tire adhesion coefficient and the lateral tire adhesion coefficient, a fuzzy reasoning strategy of fusing the longitudinal tire adhesion coefficient and the lateral tire adhesion coefficient is designed. The results of vehicle tests prove that the method proposed in this paper can estimate the peak adhesion coefficient of pavement quickly and accurately