Fast and Accurate Neural Word Segmentation for Chinese

Neural models with minimal feature engineering have achieved competitive performance against traditional methods for the task of Chinese word segmentation. However, both training and working procedures of the current neural models are computationally inefficient. This paper presents a greedy neural word segmenter with balanced word and character embedding inputs to alleviate the existing drawbacks. Our segmenter is truly end-to-end, capable of performing segmentation much faster and even more accurate than state-of-the-art neural models on Chinese benchmark datasets.Comment: To appear in ACL201

NEYRAUDIA REYNEDIANA -EXCELLENT SOIL CONSERVATION GRASS

Abstract Neyraudia reynediana is the excellent grass species for soil conservation. In South China, adopting Neyraudia reynediana as main conservation species in the water-eroded desert, it can effectively control soil erosion by covering the ground within six months, facilitating the improvement on poor ecological environment in watereroded desert, creating the favorite conditions for introduction and propagation of Dicranopteris dichotoma and other local grass species, so as to accelerate the recovery of vegetation in water-eroded desert. The physiologic and biochemical criterion measurement to moisture threaten treatment of four grass species -Neyraudia reynediana, vetiver, Bahia grass and Miscanthus floridulus -shows that Neyraudia reynediana enjoys the best capacity of drought resistance and adversity adaptability. By using the Neyraudia reynediana as a fast afforestation technique, it successfully solved the difficult problems of vegetation recovery management in the waste mines of kaolin, gold and gangue

Melanocortin 1 receptor targeted imaging of melanoma with gold nanocages and positron emission tomography

Purpose: Melanoma is a lethal skin cancer with unmet clinical needs for targeted imaging and therapy. Nanoscale materials conjugated with targeting components have shown great potential to improve tumor delivery efficiency while minimizing undesirable side effects in vivo. Herein, we proposed to develop targeted nanoparticles for melanoma theranostics. Method: In this work, gold nanocages (AuNCs) were conjugated with α-melanocyte-stimulating hormone (α-MSH) peptide and radiolabeled with 64Cu for melanocortin 1 receptor-(MC1R) targeted positron emission tomography (PET) in a mouse B16/F10 melanoma model. Results: Their controlled synthesis and surface chemistry enabled well-defined structure and radiolabeling efficiency. In vivo pharmacokinetic evaluation demonstrated comparable organ distribution between the targeted and nontargeted AuNCs. However, micro-PET/computed tomography (CT) imaging demonstrated specific and improved tumor accumulation via MC1R-mediated delivery. By increasing the coverage density of α-MSH peptide on AuNCs, the tumor delivery efficiency was improved. Conclusion: The controlled synthesis, sensitive PET imaging, and optimal tumor targeting suggested the potential of targeted AuNCs for melanoma theranostics. </jats:sec

Application of Bunchy TiO2 Hierarchical Microspheres as a Scattering Layer for Dye-Sensitized Solar Cells

A novel bunchy TiO2 hierarchical microspheres composite nanostructure with strings of anatase TiO2 hierarchical micro-spheres and rutile nanobelts framework (HSN) was synthesized via an one-pot hydrothermal process. This new structure presents great specific surface area, large pore size distribution, homogeneous three-dimensional (3D) structure, high crystallinity and excellent light scattering performance simultaneously. The bi-layer photoanode film was successfully prepared which TiO2 P25 as absorption layer and HSN as an efficient scattering layer on the top of TiO2 P25 film in dye sensitized solar cells (DSSC). The bi-layer DSSC taken on a great progress in the power conversion efficiency (PCE) achieved 8.08%. However, the PCE of single and double layer TiO2 film DSSCs just showed 6.72% and 3.67% respectively. Such improvement was mainly because of the efficient scattering centers (HSN) which can bring the enhanced dye loading, fast charge transfer and excellent light harvesting efficiency

LZ-101, a novel derivative of danofloxacin, induces mitochondrial apoptosis by stabilizing FOXO3a via blocking autophagy flux in NSCLC cells

Non-small-cell lung carcinoma (NSCLC) continues to be a vital disease worldwide for its high incidence and consequent mortality rate. In this study, we investigated the anti-cancer effect of LZ-101, a new derivative of danofloxacin, against non-small-cell lung cancer and the underlying mechanisms. In vitro, LZ-101 inhibited the viability of human non-small cell lung cancer cell lines. We demonstrated that LZ-101 induced mitochondrial-mediated apoptosis by increasing Bax/Bcl-2 ratio, loss of mitochondrial membrane potential (ΔΨm), release of cytochrome c (Cyt c) and apoptosis-inducing factor (AIF) in A549 cells. Further research illuminated that LZ-101 induced apoptosis was related to the activation of FOXO3a/Bim pathway. Moreover, we found that LZ-101 increased the stability of FOXO3a by blocking autophagy-dependent FOXO3a degradation. However, inhibition of autophagosome formation abolished FOXO3a stabilization and apoptosis induced by LZ-101. In vivo, LZ-101 exerted a remarkable anti-tumor activity with high safety in xenograft model inoculated A549 tumor through the same mechanism as in our in vitro study. In conclusion, our findings indicated that LZ-101 induces mitochondrial apoptosis and stabilizes FOXO3a by blocking autophagy flux