7 research outputs found
Development of a Practical and Efficient Synthesis of SIPI-4884, a HMG CoA Reductase Inhibitor for the Treatment of Hypercholesterolemia
An
improved process of the novel HMG CoA reductase inhibitor SIPI-4884
has been developed for early preclinical pharmacology and safety studies,
and it was made up with an efficient nine-step and scalable process.
Significant improvements in the nucleophilic substitution, reduction,
Wittig–Horner reaction, and preparation of calcium salt were
demonstrated. The overall yield was improved to 17.2%
Synthesis of PtPd Bimetal Nanocrystals with Controllable Shape, Composition, and Their Tunable Catalytic Properties
We report a facile synthetic strategy to single-crystalline
PtPd
nanocrystals with controllable shapes and tunable compositions. In
the developed synthesis, the molar ratio of the starting precursors
determines the composition in the final PtPd nanocrystals, while the
halides function as the shape-directing agent to induce the formation
of PtPd nanocrystals with cubic or octahedral/tetrahedral morphology.
These obtained PtPd nanocrystals exhibit high activity in the hydrogenation
of nitrobenzene, and their performance is highly shape- and composition-dependent
with Pt in ∼50% showing the optimum activity and the {100}-facet-enclosed
PtPd nanocrystals demonstrating a higher activity than the {111}-facet-bounded
PtPd nanocrystals
Stabilization of High-Performance Oxygen Reduction Reaction Pt Electrocatalyst Supported on Reduced Graphene Oxide/Carbon Black Composite
Oxygen reduction reaction (ORR) catalyst supported by
hybrid composite
materials is prepared by well-mixing carbon black (CB) with Pt-loaded
reduced graphene oxide (RGO). With the insertion of CB particles between
RGO sheets, stacking of RGO can be effectively prevented, promoting
diffusion of oxygen molecules through the RGO sheets and enhancing
the ORR electrocatalytic activity. The accelerated durability test
(ADT) demonstrates that the hybrid supporting material can dramatically
enhance the durability of the catalyst and retain the electrochemical
surface area (ECSA) of Pt: the final ECSA of the Pt nanocrystal on
the hybrid support after 20 000 ADT cycles is retained at >95%,
much higher than the commercially available catalyst. We suggest that
the unique 2D profile of the RGO functions as a barrier, preventing
leaching of Pt into the electrolyte, and the CB in the vicinity acts
as active sites to recapture/renucleate the dissolved Pt species.
We furthermore demonstrate that the working mechanism can be applied
to the commercial Pt/C product to greatly enhance its durability
A Rational Biomimetic Approach to Structure Defect Generation in Colloidal Nanocrystals
Controlling the morphology of nanocrystals (NCs) is of paramount importance for both fundamental studies and practical applications. The morphology of NCs is determined by the seed structure and the following facet growth. While means for directing facet formation in NC growth have been extensively studied, rational strategies for the production of NCs bearing structure defects in seeds have been much less explored. Here, we report mechanistic investigations of high density twin formation induced by specific peptides in platinum (Pt) NC growth, on the basis of which we derive principles that can serve as guidelines for the rational design of molecular surfactants to introduce high yield twinning in noble metal NC syntheses. Two synergistic factors are identified in producing twinned Pt NCs with the peptide: (1) the altered reduction kinetics and crystal growth pathway as a result of the complex formation between the histidine residue on the peptide and Pt ions, and (2) the preferential stabilization of {111} planes upon the formation of twinned seeds. We further apply the discovered principles to the design of small organic molecules bearing similar binding motifs as ligands/surfactants to create single and multiple twinned Pd and Rh NCs. Our studies demonstrate the rich information derived from biomimetic synthesis and the broad applicability of biomimetic principles to NC synthesis for diverse property tailoring
Addition of <i>N</i>‑Heterocyclic Carbene Catalyst to Aryl Esters Induces Remote C–Si Bond Activation and Benzylic Carbon Functionalization
Through
the incorporation of a silicon atom to an aryl carboxylic
ester substrate, the resulting C–Si bond can be activated via
the addition of a carbene catalyst on a remote site. This strategy
allows for efficient functionalization of the benzylic sp<sup>3</sup>-carbons of aryl carboxylic esters
Significantly Enhanced Visible Light Photoelectrochemical Activity in TiO<sub>2</sub> Nanowire Arrays by Nitrogen Implantation
Titanium oxide (TiO<sub>2</sub>)
represents one of most widely studied materials for photoelectrochemical
(PEC) water splitting but is severely limited by its poor efficiency
in the visible light range. Here, we report a significant enhancement
of visible light photoactivity in nitrogen-implanted TiO<sub>2</sub> (N-TiO<sub>2</sub>) nanowire arrays. Our systematic studies show
that a post-implantation thermal annealing treatment can selectively
enrich the substitutional nitrogen dopants, which is essential for
activating the nitrogen implanted TiO<sub>2</sub> to achieve greatly
enhanced visible light photoactivity. An incident photon to electron
conversion efficiency (IPCE) of ∼10% is achieved at 450 nm
in N-TiO<sub>2</sub> without any other cocatalyst, far exceeding that
in pristine TiO<sub>2</sub> nanowires (∼0.2%). The integration
of oxygen evolution reaction (OER) cocatalyst with N-TiO<sub>2</sub> can further increase the IPCE at 450 nm to ∼17% and deliver
an unprecedented overall photocurrent density of 1.9 mA/cm<sup>2</sup>, by integrating the IPCE spectrum with standard AM 1.5G solar spectrum.
Systematic photoelectrochemical and electrochemical studies demonstrated
that the enhanced PEC performance can be attributed to the significantly
improved visible light absorption and more efficient charge separation.
Our studies demonstrate the implantation approach can be used to reliably
dope TiO<sub>2</sub> to achieve the best performed N-TiO<sub>2</sub> photoelectrodes to date and may be extended to fundamentally modify
other semiconductor materials for PEC water splitting
Cu-Modified Palladium Catalysts: Boosting Formate Electrooxidation via Interfacially OH<sub>ad</sub>-Driven H<sub>ad</sub> Removal
Direct formate fuel cells have gained traction due to
their eco-friendly
credentials and inherent safety. However, their potential is hampered
by the kinetic challenges of the formate oxidation reaction (FOR)
on Pd-based catalysts, chiefly due to the unfavorable adsorption of
hydrogen species (Had). These species clog the active sites,
hindering efficient catalysis. Here, we introduce a straightforward
strategy to remedy this bottleneck by incorporating Pd with Cu to
expedite the removal of Pd–Had in alkaline media.
Notably, Cu plays a pivotal role in bolstering the concentration of
hydroxyl adsorbates (OHad) on the surface of catalyst.
These OHad species can react with Had, effectively
unblocking the active sites for FOR. The as-synthesized catalyst of
PdCu/C exhibits a superior FOR performance, boasting a remarkable
mass activity of 3.62 A mg–1. Through CO-stripping
voltammetry, we discern that the presence of Cu in Pd markedly speeds
up the formation of adsorbed hydroxyl species (OHad) at
diminished potentials. This, in turn, aids the oxidative removal of
Pd–Had, leveraging a synergistic mechanism during
FOR. Density functional theory computations further reveal intensified
interactions between adsorbed oxygen species and intermediates, underscoring
that the Cu–Pd interface exhibits greater oxyphilicity compared
to pristine Pd. In this study, we present both experimental and theoretical
corroborations, unequivocally highlighting that the integrated copper
species markedly amplify the generation of OHad, ensuring
efficient removal of Had. This work paves the way, shedding
light on the strategic design of high-performing FOR catalysts