24 research outputs found
Increased Low-Frequency Resting-State Brain Activity by High-Frequency Repetitive TMS on the Left Dorsolateral Prefrontal Cortex
Beneficial effects of repetitive transcranial magnetic stimulation (rTMS) on left dorsolateral prefrontal cortex (DLPFC) have been consistently shown for treating various neuropsychiatrical or neuropsychological disorders, but relatively little is known about its neural mechanisms. Here we conducted a randomized, double-blind, SHAM-controlled study to assess the effects of high-frequency left DLPFC rTMS on resting-state activity. Thirty-eight young healthy subjects received two sessions of either real rTMS (N = 18, 90% motor-threshold; left DLPFC at 20 Hz) or SHAM TMS (N = 20) and functional magnetic resonance imaging scan during rest in 2 days separated by 48 h. Resting-state bran activity was measured with the fractional amplitude of low-frequency fluctuation (fALFF) and functional connectivity (FC). Increased fALFF was found in rostral anterior cingulate cortex (rACC) after 20 Hz rTMS, while no changes were observed after SHAM stimulation. Using the suprathreshold rACC cluster as the seed, increased FC was found in left temporal cortex (stimulation vs. group interaction). These data suggest that high-frequency rTMS on left DLPFC enhances low-frequency resting-state brain activity in the target site and remote sites as reflected by fALFF and FC
Increased Low-Frequency Resting-State Brain Activity by High-Frequency Repetitive TMS on the Left Dorsolateral Prefrontal Cortex
Adjuvant chemotherapy or no adjuvant chemotherapy? A prediction model for the risk stratification of recurrence or metastasis of nasopharyngeal carcinoma combining MRI radiomics with clinical factors
Adjuvant chemotherapy or no adjuvant chemotherapy? A prediction model for the risk stratification of recurrence or metastasis of nasopharyngeal carcinoma combining MRI radiomics with clinical factors.
BackgroundDose adjuvant chemotherapy (AC) should be offered in nasopharyngeal carcinoma (NPC) patients? Different guidelines provided the different recommendations.MethodsIn this retrospective study, a total of 140 patients were enrolled and followed for 3 years, with 24 clinical features being collected. The imaging features on the enhanced-MRI sequence were extracted by using PyRadiomics platform. The pearson correlation coefficient and the random forest was used to filter the features associated with recurrence or metastasis. A clinical-radiomics model (CRM) was constructed by the Cox multivariable analysis in training cohort, and was validated in validation cohort. All patients were divided into high- and low-risk groups through the median Rad-score of the model. The Kaplan-Meier survival curves were used to compare the 3-year recurrence or metastasis free rate (RMFR) of patients with or without AC in high- and low-groups.ResultsIn total, 960 imaging features were extracted. A CRM was constructed from nine features (seven imaging features and two clinical factors). In the training cohort, the area under curve (AUC) of CRM for 3-year RMFR was 0.872 (P ConclusionConsidering increasing RMFR, a prediction model for NPC based on two clinical factors and seven imaging features suggested the AC needs to be added to patients in the high-risk group and not in the low-risk group
A Theoretical Study on the Structural and Energy Spectral Properties of Ce<sup>3+</sup> Ions Doped in Various Fluoride Compounds
Geometry optimization and wave function-based complete-active-space
self-consistent field-embedded cluster calculations have been performed
for a series of Ce<sup>3+</sup>-doped fluoride compounds (CaF<sub>2</sub>, YF<sub>3</sub>, LaF<sub>3</sub>, KMgF<sub>3</sub>, LiYF<sub>4</sub>, K<sub>2</sub>YF<sub>5</sub>, and KY<sub>3</sub>F<sub>10</sub>) to investigate local coordination structures, crystal field parameters,
and 5d<sup>1</sup> energy-level structures of doping Ce<sup>3+</sup> ions. The crystal-field parameters of Ce<sup>3+</sup> are extracted
from the calculated energies and wave functions. The calculated crystal-field
parameters and 5d<sup>1</sup> energy-level structures show excellent
consistency with the experimental results. Our calculations show that
the onset of 4f → 5d absorption, which is important in phosphors
and scintillators, can be well-predicted. Apart from that, the distortion
of local structure due to doping, the wave functions, and the crystal-field
parameters of 4f<sup>1</sup> and 5d<sup>1</sup> states of Ce<sup>3+</sup> in the hosts can be obtained. Those can seldom be obtained by fitting
empirical crystal-field Hamiltonian to experimental data but are required
by some detailed theoretical analysis, such as the calculation of
transition intensities and hyperfine splittings. The obtained crystal-field
parameters of Ce<sup>3+</sup> may also be useful for other lanthanide
ions in the same hosts
Features extracted from targets outlined by an associate chief physician.
Features extracted from targets outlined by an associate chief physician.</p
Supplementary material_code.
BackgroundDose adjuvant chemotherapy (AC) should be offered in nasopharyngeal carcinoma (NPC) patients? Different guidelines provided the different recommendations.MethodsIn this retrospective study, a total of 140 patients were enrolled and followed for 3 years, with 24 clinical features being collected. The imaging features on the enhanced-MRI sequence were extracted by using PyRadiomics platform. The pearson correlation coefficient and the random forest was used to filter the features associated with recurrence or metastasis. A clinical-radiomics model (CRM) was constructed by the Cox multivariable analysis in training cohort, and was validated in validation cohort. All patients were divided into high- and low-risk groups through the median Rad-score of the model. The Kaplan-Meier survival curves were used to compare the 3-year recurrence or metastasis free rate (RMFR) of patients with or without AC in high- and low-groups.ResultsIn total, 960 imaging features were extracted. A CRM was constructed from nine features (seven imaging features and two clinical factors). In the training cohort, the area under curve (AUC) of CRM for 3-year RMFR was 0.872 (P ConclusionConsidering increasing RMFR, a prediction model for NPC based on two clinical factors and seven imaging features suggested the AC needs to be added to patients in the high-risk group and not in the low-risk group.</div
KM curves of training cohort and validation cohort.
a) The KM curves of patients with the RMFS, 3-year RMFR were 74.5% and 73.8% in training and validation cohorts, respectively (p>0.05); b) The KM curves of patient’s CSS in training cohort and validation cohort. The 3-year CSS rates were 90.8% and 81%, respectively (p>0.05). P≥0.05 indicates no statistically significant difference between the two groups.</p
Features extracted from targets outlined by another associate chief physician.
Features extracted from targets outlined by another associate chief physician.</p
The AUC values, sensitivity and specificity of the different treatment modes in CRM.
The AUC values, sensitivity and specificity of the different treatment modes in CRM.</p