USING STATISTICAL METHOD TO REVEAL BIOLOGICAL ASPECT OF HUMAN DISEASE: STUDY OF GLIOBLASTOMA BY USING COMPARATIVE GENOMIC HYBRIDIZATION (CGH) METHOD

Glioblastoma is a WHO grade IV tumor with high mortality rate. In order to identify the underlying biological causation of this disease, a comparative genomic hybridization dataset generated from 170 patients' tumor samples was analyzed. Of many available segmentation algorithms, I focused mainly on two most acceptable methods: Homogeneous Hidden Markov Models (HHMM) and Circular Binary Segmentation (CBS). Simulations show that CBS tends to give better segmentation result with low false discovery rate. HHMM failed to identify many obvious breakpoints that CBS identified. On the other hand, HHMM succeeds in identifying many single probe aberrations. Applying other statistical algorithms revealed distinct biological fingerprints of Glioblastoma disease, which includes many signature genes and biological pathways. Survival analysis also reveals that several segments actually correlate to the extended survival time of some patients. In summary, this work shows the importance of statistical model or algorithms in the modern genomic research

Rank-1 Constrained Multichannel Wiener Filter for Speech Recognition in Noisy Environments

Multichannel linear filters, such as the Multichannel Wiener Filter (MWF) and the Generalized Eigenvalue (GEV) beamformer are popular signal processing techniques which can improve speech recognition performance. In this paper, we present an experimental study on these linear filters in a specific speech recognition task, namely the CHiME-4 challenge, which features real recordings in multiple noisy environments. Specifically, the rank-1 MWF is employed for noise reduction and a new constant residual noise power constraint is derived which enhances the recognition performance. To fulfill the underlying rank-1 assumption, the speech covariance matrix is reconstructed based on eigenvectors or generalized eigenvectors. Then the rank-1 constrained MWF is evaluated with alternative multichannel linear filters under the same framework, which involves a Bidirectional Long Short-Term Memory (BLSTM) network for mask estimation. The proposed filter outperforms alternative ones, leading to a 40% relative Word Error Rate (WER) reduction compared with the baseline Weighted Delay and Sum (WDAS) beamformer on the real test set, and a 15% relative WER reduction compared with the GEV-BAN method. The results also suggest that the speech recognition accuracy correlates more with the Mel-frequency cepstral coefficients (MFCC) feature variance than with the noise reduction or the speech distortion level.Comment: for Computer Speech and Languag

ODN: Opening the Deep Network for Open-set Action Recognition

In recent years, the performance of action recognition has been significantly improved with the help of deep neural networks. Most of the existing action recognition works hold the \textit{closed-set} assumption that all action categories are known beforehand while deep networks can be well trained for these categories. However, action recognition in the real world is essentially an \textit{open-set} problem, namely, it is impossible to know all action categories beforehand and consequently infeasible to prepare sufficient training samples for those emerging categories. In this case, applying closed-set recognition methods will definitely lead to unseen-category errors. To address this challenge, we propose the Open Deep Network (ODN) for the open-set action recognition task. Technologically, ODN detects new categories by applying a multi-class triplet thresholding method, and then dynamically reconstructs the classification layer and "opens" the deep network by adding predictors for new categories continually. In order to transfer the learned knowledge to the new category, two novel methods, Emphasis Initialization and Allometry Training, are adopted to initialize and incrementally train the new predictor so that only few samples are needed to fine-tune the model. Extensive experiments show that ODN can effectively detect and recognize new categories with little human intervention, thus applicable to the open-set action recognition tasks in the real world. Moreover, ODN can even achieve comparable performance to some closed-set methods.Comment: 6 pages, 3 figures, ICME 201