Community discovery from social media by low-rank matrix recovery

The pervasive usage and reach of social media have attracted a surge of attention in the multimedia research community. Community discovery from social media has therefore become an important yet challenging issue. However, due to the subjective generating process, the explicitly observed communities (e.g., group-user and user-user relationship) are often noisy and incomplete in nature. This paper presents a novel approach to discovering communities from social media, including the group membership and user friend structure, by exploring a low-rank matrix recovery technique. In particular, we take Flickr as one exemplary social media platform. We first model the observed indicator matrix of the Flickr community as a summation of a low-rank true matrix and a sparse error matrix. We then formulate an optimization problem by regularizing the true matrix to coincide with the available rich context and content (i.e., photos and their associated tags). An iterative algorithm is developed to recover the true community indicator matrix. The proposed approach leads to a variety of social applications, including community visualization, interest group refinement, friend suggestion, and influential user identification. The evaluations on a large-scale testbed, consisting of 4,919 Flickr users, 1,467 interest groups, and over five million photos, show that our approach opens a new yet effective perspective to solve social network problems with sparse learning technique. Despite being focused on Flickr, our technique can be applied in any other social media community. </jats:p

DVH Prediction for VMAT in NPC with GRU-RNN: An Improved Method by Considering Biological Effects

Purpose. A recurrent neural network (RNN) and its variants such as gated recurrent unit-based RNN (GRU-RNN) were found to be very suitable for dose-volume histogram (DVH) prediction in our previously published work. Using the dosimetric information generated by nonmodulated beams of different orientations, the GRU-RNN model was capable of accurate DVH prediction for nasopharyngeal carcinoma (NPC) treatment planning. On the basis of our previous work, we proposed an improved approach and aimed to further improve the DVH prediction accuracy as well as study the feasibility of applying the proposed method to relatively small-size patient data. Methods. Eighty NPC volumetric modulated arc therapy (VMAT) plans with local IRB’s approval in recent two years were retrospectively and randomly selected in this study. All these original plans were created using the Eclipse treatment planning system (V13.5, Varian Medical Systems, USA) with ≥95% of PGTVnx receiving the prescribed doses of 70 Gy, ≥95% of PGTVnd receiving 66 Gy, and ≥95% of PTV receiving 60 Gy. Among them, fifty plans were used to train the DVH prediction model, and the remaining were used for testing. On the basis of our previously published work, we simplified the 3-layer GRU-RNN model to a single-layer model and further trained every organ at risk (OAR) separately with an OAR-specific equivalent uniform dose- (EUD-) based loss function. Results. The results of linear least squares regression obtained by the new proposed method showed the excellent agreements between the predictions and the original plans with the correlation coefficient r=0.976 and 0.968 for EUD results and maximum dose results, respectively, and the coefficient r of our previously published method was 0.957 and 0.946, respectively. The Wilcoxon signed-rank test results between the proposed and the previous work showed that the proposed method could significantly improve the EUD prediction accuracy for the brainstem, spinal cord, and temporal lobes with a p value < 0.01. Conclusions. The accuracy of DVH prediction achieved in different OARs showed the great improvements compared to the previous works, and more importantly, the effectiveness and robustness showed by the simplified GRU-RNN trained from relatively small-size DVH samples, fully demonstrated the feasibility of applying the proposed method to small-size patient data. Excellent agreements in both EUD results and maximum dose results between the predictions and original plans indicated the application prospect in a physically and biologically related (or a mixture of both) model for treatment planning

Compact high-voltage, low-impedance nanosecond pulse generators for biomedical applications

EI

Manipulation of pore structure during manufacture of agarose microspheres for bioseparation

Agarose microspheres with a controllable pore structure were manufactured by varying agarose types and crosslinking degrees. Various agarose could tailor the gel formation of microspheres matrix and thus affect the final pore structures. Small pores in microspheres could be fabricated by agarose with a higher molecular weight, which was demonstrated by the packed column with lower distribution coefficient (K-av) values measured by gel filtration chromatography. Further, higherK(av)values also demonstrated that more and larger pores were formed with increasing the crosslinking degree of agarose microspheres. Either using agarose with a high molecular weight or increasing the crosslinking degree would finally lead to the enhancement of the flow rate during flow performance of packed column as necessary for improving separation efficiency. This provides a foundation for high-resolution chromatography with a controllable separation range as beneficial for downstream process