2 research outputs found
One-Pot Synthesis of 3,5-Disubstituted and Polysubstituted Phenols from Acyclic Precursors
A new
strategy for the synthesis of 3,5-disubstituted phenols is
established through one-pot Robinson annulation of α,β-unsaturated
ketones with α-fluoro-β-ketoesters followed by in situ
dehydrofluorination and tautomerization. This method has been extended
to the synthesis of polysubstituted phenols and applied in the preparation
of biologically active compounds
One-Pot Synthesis of 3,5-Disubstituted and Polysubstituted Phenols from Acyclic Precursors
A new
strategy for the synthesis of 3,5-disubstituted phenols is
established through one-pot Robinson annulation of α,β-unsaturated
ketones with α-fluoro-β-ketoesters followed by in situ
dehydrofluorination and tautomerization. This method has been extended
to the synthesis of polysubstituted phenols and applied in the preparation
of biologically active compounds