Statistical inference for semiparametric varying-coefficient partially linear models with error-prone linear covariates

We study semiparametric varying-coefficient partially linear models when some linear covariates are not observed, but ancillary variables are available. Semiparametric profile least-square based estimation procedures are developed for parametric and nonparametric components after we calibrate the error-prone covariates. Asymptotic properties of the proposed estimators are established. We also propose the profile least-square based ratio test and Wald test to identify significant parametric and nonparametric components. To improve accuracy of the proposed tests for small or moderate sample sizes, a wild bootstrap version is also proposed to calculate the critical values. Intensive simulation experiments are conducted to illustrate the proposed approaches.Comment: Published in at http://dx.doi.org/10.1214/07-AOS561 the Annals of Statistics (http://www.imstat.org/aos/) by the Institute of Mathematical Statistics (http://www.imstat.org

Optimization of Fast-Decodable Full-Rate STBC with Non-Vanishing Determinants

Full-rate STBC (space-time block codes) with non-vanishing determinants achieve the optimal diversity-multiplexing tradeoff but incur high decoding complexity. To permit fast decoding, Sezginer, Sari and Biglieri proposed an STBC structure with special QR decomposition characteristics. In this paper, we adopt a simplified form of this fast-decodable code structure and present a new way to optimize the code analytically. We show that the signal constellation topology (such as QAM, APSK, or PSK) has a critical impact on the existence of non-vanishing determinants of the full-rate STBC. In particular, we show for the first time that, in order for APSK-STBC to achieve non-vanishing determinant, an APSK constellation topology with constellation points lying on square grid and ring radius \sqrt{m^2+n^2} (m,n\emph{\emph{integers}}) needs to be used. For signal constellations with vanishing determinants, we present a methodology to analytically optimize the full-rate STBC at specific constellation dimension.Comment: Accepted by IEEE Transactions on Communication

Genetic heterogeneity of pseudoxanthoma elasticum: the Chinese signature profile of ABCC6 and ENPP1 mutations.

Pseudoxanthoma elasticum (PXE), an autosomal recessive disorder characterized by ectopic mineralization, is caused by mutations in the ABCC6 gene. We examined clinically 29 Chinese PXE patients from unrelated families, so far the largest cohort of Asian PXE patients. In a subset of 22 patients, we sequenced ABCC6 and another candidate gene, ENPP1, and conducted pathogenicity analyses for each variant. We identified a total of 17 distinct mutations in ABCC6, 15 of them being, to our knowledge, previously unreported, including 5 frameshift and 10 missense variants. In addition, a missense mutation in combination with a recurrent nonsense mutation in ENPP1 was discovered in a pediatric PXE case. No cases with p.R1141X or del23-29 mutations, common in Caucasian patient populations, were identified. The 10 missense mutations in ABCC6 were expressed in the mouse liver via hydrodynamic tail-vein injections. One mutant protein showed cytoplasmic accumulation indicating abnormal subcellular trafficking, while the other nine mutants showed correct plasma membrane location. These nine mutations were further investigated for their pathogenicity using a recently developed zebrafish mRNA rescue assay. Minimal rescue of the morpholino-induced phenotype was achieved with eight of the nine mutant human ABCC6 mRNAs tested, implying pathogenicity. This study demonstrates that the Chinese PXE population harbors unique ABCC6 mutations. These genetic data have implications for allele-specific therapy currently being developed for PXE

Low-PMEPR Preamble Sequence Design for Dynamic Spectrum Allocation in OFDMA Systems

Orthogonal Frequency Division Multiple Access (OFDMA) with Dynamic spectrum allocation (DSA) is able to provide a wide range of data rate requirements. This paper is focused on the design of preamble sequences in OFDMA systems with low peak-to-mean envelope power ratio (PMEPR) property in the context of DSA. We propose a systematic preamble sequence design which gives rise to low PMEPR for possibly non-contiguous spectrum allocations. With the aid of Golay-Davis-Jedwab (GDJ) sequences, two classes of preamble sequences are presented. We prove that their PMEPRs are upper bounded by 4 for any DSA over a chunk of four contiguous resource blocks