In fitting spline models, colorectal cancer mortality as a function of different classifications.

<p>Dotted lines indicate the 95% confidence interval.</p

Distributions of selected characteristics in gastric cancer cases and controls (n = 404 for both case and control groups).

<p>*Two-sided χ² test.</p

Survival analysis of haplotypes of the six SNPs in HPSE (n = 381).

<p>*Based on Cox proportional hazards survival regression in haplotype-based association analysis using the Stochastic-EM algorithm.</p><p>Abbreviation: HR, hazard rate; CI, confidence interval.</p

Kaplan-Meier survival curve analysis with rs4693608 genotypes.

<p>Results show that accumulative survival rate of 381 cases with gastric cancer were associated with the different rs4693608 genotypes in HPSE gene.</p

Associations between haplotype frequencies of the six SNPs in HPSE and clinicopathological parameters (n = 404).

<p>*Two-sided χ² test, each haplotype compared with all other haplotypes.</p>#<p>Statistically significant (P<0.05).</p

The distribution of the pN & LNR(A) and LODDS & LNR(B).

<p>The distribution of the pN & LNR(A) and LODDS & LNR(B).</p

Survival curves of colorectal cancer patients according to three classifications (pN, LNR, LODDS) are depicted.

<p>Survival curves of colorectal cancer patients according to three classifications (pN, LNR, LODDS) are depicted.</p

Univariate and multivariate Cox proportional hazard analysis for gastric cancer patients of the six SNPs in HPSE Versus clinicopathological parameters (n = 381).

<p>*Statistically significant (P<0.05).</p><p>Abbreviation: HR, hazard rate; CI, confidence interval.</p

Univariate and Three-step Multivariate Analysis (Cox Proportional Hazard Model) of Prognostic Factors.

<p>RR^a: relative risk.</p><p>CI^b: confidence interval.</p>*<p>: continuous variable.</p

Univariate analysis of the prognostic factors for patients with colorectal cancer.

<p>N^a: Number of patients.</p><p>5-YSR^b: 5-year accumulative survival rate.</p>*<p>: P values were made by log-rank test.</p