Collective cell migration: Implications for wound healing and cancer invasion.

During embryonic morphogenesis, wound repair and cancer invasion, cells often migrate collectively via tight cell-cell junctions, a process named collective migration. During such migration, cells move as coherent groups, large cell sheets, strands or tubes rather than individually. One unexpected finding regarding collective cell migration is that being a "multicellular structure" enables cells to better respond to chemical and physical cues, when compared with isolated cells. This is important because epithelial cells heal wounds via the migration of large sheets of cells with tight intercellular connections. Recent studies have gained some mechanistic insights that will benefit the clinical understanding of wound healing in general. In this review, we will briefly introduce the role of collective cell migration in wound healing, regeneration and cancer invasion and discuss its underlying mechanisms as well as implications for wound healing

Actively controlling the topological transition of dispersion based on electrically controllable metamaterials

Topological transition of the iso-frequency contour (IFC) from a closed ellipsoid to an open hyperboloid, will provide unique capabilities for controlling the propagation of light. However, the ability to actively tune these effects remains elusive and the related experimental observations are highly desirable. Here, tunable electric IFC in periodic structure which is composed of graphene/dielectric multilayers is investigated by tuning the chemical potential of graphene layer. Specially, we present the actively controlled transportation in two kinds of anisotropic zero-index media containing PEC/PMC impurities. At last, by adding variable capacitance diodes into two-dimensional transmission-line system, we present the experimental demonstration of the actively controlled magnetic topological transition of dispersion based on electrically controllable metamaterials. With the increase of voltage, we measure the different emission patterns from a point source inside the structure and observe the phase-transition process of IFCs. The realization of actively tuned topological transition will opens up a new avenue in the dynamical control of metamaterials.Comment: 21 pages,8 figure

Top Hypercharge

We propose a top hypercharge model with gauge symmetry SU(3)_C x SU(2)_L x U(1)_1 x U(1)_2 where the first two families of the Standard Model (SM) fermions are charged under U(1)_1 while the third family is charged under U(1)_2. The U(1)_1 x U(1)_2 gauge symmetry is broken down to the U(1)_Y gauge symmetry, when a SM singlet Higgs field acquires a vacuum expectation value. We consider the electroweak constraints, and compare the fit to experimental observables to that of the SM. We study the quark CKM mixing between the first two families and the third family, the neutrino masses and mixing, the flavour changing neutral current effects in meson mixing and decays, the Z' discovery potential at the Large Hadron Collider, the dark matter with a gauged Z_2 symmetry, and the Higgs boson masses.Comment: 17 pages and 4 figure