Bland-Altman plots of each macular layer thickness (mGCIPL, mGCC and TRL) and cpRNFL thickness.

<p>The plots also show significant correlations in cpRNFL, mGCIPL and mGCC thickness that the difference (Wide–Standard macula or disc) is larger as the measurement value becomes thicker.</p

Dot plot graphs with the values from the wide and standard macular/disc scan measurements.

<p>Total (average) thickness of (A) ganglion cell layer plus inner plexiform layer (mGCIPL) and (B) macular ganglion cell layer (mGCC), measured by wide scan (X axis) and standard macula scan (Y axis), and total (average) thickness of (C) circumpapillary retinal nerve fiber layer (cpRNFL), measured by wide scan (X axis) and standard disc scan (Y axis), in normal and glaucoma groups are shown.</p

Agreement between wide and standard macula scan measurements for macular thickness parameters, and wide and standard disc scan for circumpapillary retinal nerve fiber layer (cpRNFL) thickness parameters.

<p>Agreement between wide and standard macula scan measurements for macular thickness parameters, and wide and standard disc scan for circumpapillary retinal nerve fiber layer (cpRNFL) thickness parameters.</p

Repeatability of wide and standard macula scan measurements of macular thickness, and wide and standard disc scans for circumpapillary retinal nerve fiber layer (cpRNFL) thickness parameters.

<p>Repeatability of wide and standard macula scan measurements of macular thickness, and wide and standard disc scans for circumpapillary retinal nerve fiber layer (cpRNFL) thickness parameters.</p

Examples of Topcon SS-OCT reports for each scan in a healthy eye.

<p>(A) Wide scan report, (B) standard macula scan report and (C) standard disc scan report. Wide report provides both macular and circumpapillary parameters.</p

Comparison of areas under the receiver operating characteristic curves (AUCs) between wide and standard macula scans of macular thickness parameters and between wide and standard disc scans of circumpapillary retinal nerve fiber layer (cpRNFL) thickness parameters for assessing glaucoma.

<p>Comparison of areas under the receiver operating characteristic curves (AUCs) between wide and standard macula scans of macular thickness parameters and between wide and standard disc scans of circumpapillary retinal nerve fiber layer (cpRNFL) thickness parameters for assessing glaucoma.</p

Demographics and ocular data including macular ganglion cell layer plus inner plexiform layer (mGCIPL), mGCIPL plus nerve fiber layer (mGCC) and total retinal layer (TRL) measurements by swept source optical coherence tomography (SS-OCT) wide scan and standard macula scan, and circumpapillary retinal nerve fiber layer (cpRNFL) measurements by SS-OCT wide scan and standard disc scan of normal subjects and glaucoma patients.

<p>Demographics and ocular data including macular ganglion cell layer plus inner plexiform layer (mGCIPL), mGCIPL plus nerve fiber layer (mGCC) and total retinal layer (TRL) measurements by swept source optical coherence tomography (SS-OCT) wide scan and standard macula scan, and circumpapillary retinal nerve fiber layer (cpRNFL) measurements by SS-OCT wide scan and standard disc scan of normal subjects and glaucoma patients.</p

Interpretation of optic disc center displacement in Guided Progression Analysis (GPA).

<p>(A) At second baseline exam in GPA, the optic disc margin (yellow arrowhead) showed eccentric shape compared with other exams (black arrowheads). As a result, following RNFL thickness change maps showed RNFL progression at unusual region (inferonasal rectangles) and superotemporal region (asterisk). (B) Manual delineation (blue irregular arc) indicated that the direction of optic disc center displacement was estimated to be temporal (thin black arrows). (C) In temporal displacement, overestimated inferonasal region (rectangle) at baseline study might lead to false RNFL progression in GPA. In contrast, underestimated inferotemproal region (thick gray arrows) at baseline showed increasing RNFL thickness in follow-up exams (thick black arrows). Mild superotemporal underestimation (asterisk) at baseline might underestimate actual RNFL progression. (D) Using manual selection mode in GPA, we removed second exam from analysis. Abnormal RFNL progression at inferonasal region was proven to be the effect of optic disc center displacement. Superotemporal RNFL progression became larger and more obvious. RNFL = retinal nerve fiber layer</p

Interpretation of optic disc center displacement in case of floater.

<p>(A) Floater (arrowheads) interfered with the optic disc margin detection (black irregular circle) in the inferior region. Manual delineation (blue irregular arc) indicated that the direction of optic disc center displacement was estimated to be inferonasal (arrows). (B) At next follow-up exam (6 month interval), the floater (arrowhead) moved nasal side, and then optic disc margin was clearly detected. Although inferotemporal and superotemporal RNFL defects seemed to be progressed in the RNFL deviation map, there had been no evidence of such rapid progression in other structural and functional tests. Optic disc center displacement might affect the change of red and yellow-coded area. (C) In inferonasal displacement, there was greater chance of overestimation of RNFL thickness in inferotemporal region. Superotemporal region also was suspicious of mild overestimation. These were consistent with relatively small RNFL defects in first exam. RNFL = retinal nerve fiber layer</p

Optic disc center displacement and circumpapillary RNFL thickness error.

<p>Average RNFL thickness showed the smallest error for optic disc center displacement in 8 directions. The red marks on graphs represent the first significantly different optic disc center displacement between the original and resampled RNFL measurements on repeated measures ANOVA. The central green and yellow zone represents the maximum tolerable (5% or less variability) and cautious (10% or less variability) thresholds of optic disc center displacement. RNFL = retinal nerve fiber layer; ANOVA = analysis of variance</p