Electrochemical Synthesis of Thienoacene Derivatives: Transition‐Metal‐Free Dehydrogenative C−S Coupling Promoted by a Halogen Mediator

The first electrochemical dehydrogenative C−S bond formation leading to thienoacene derivatives is described. Several thienoacene derivatives were synthesized by dehydrogenative C−H/S−H coupling. The addition of nBu4NBr, which catalytically promoted the reaction as a halogen mediator, was essential

Fogarty catheter for OLV of a neonate

Here, we report two cases involving a neonate and child in which a slip joint section was used to thread a Fogarty catheter into the endotracheal tube for one-lung ventilation (OLV). Both the neonate and infant required OLV, and were placed under general anesthesia. A Fogarty catheter was used for OLV. The Fogarty catheter was passed into the intraluminal side of the endotracheal tube through a slip joint section. OLV was maintained successfully without severe air leakage or Fogarty catheter displacement. The neonate had been intubated pre-operatively with a 3.5-mm inner diameter endotracheal tube, and we used that tube. These cases indicate that the technique can be applied to pre-operatively intubated patients and does not require surgeons to exchange endotracheal tubes. Use of the slip joint section technique facilitates Fogarty catheter fixation without additional dead space

Evaluation of Temporal Variability in Surface Chlorophyll-a Concentration Estimated by GCOM-C/SGLI in Onagawa Bay

Young Researchers Sessio

Effects of periodic robot rehabilitation using the Hybrid Assistive Limb for a year on gait function in chronic stroke patients

Using a robot for gait training in stroke patients has attracted attention for the last several decades. Previous studies reported positive effects of robot rehabilitation on gait function in the short term. However, the long-term effects of robot rehabilitation for stroke patients are still unclear. The purpose of the present study was to investigate the long-term effects of periodic gait training using the Hybrid Assistive Limb (HAL) on gait function in chronic stroke patients. Seven chronic stroke patients performed 8 gait training sessions using the HAL 3 times every few months. The maximal 10-m walk test and the 2-minute walking distance (2MWD) were measured before the first intervention and after the first, second, and third interventions. Gait speed, stride length, and cadence were calculated from the 10-m walk test. Repeated one-way analysis of variance showed a significant main effect on evaluation time of gait speed (F = 7.69, p < 0.01), 2MWD (F = 7.52, p < 0.01), stride length (F = 5.24, p < 0.01), and cadence (F = 8.43, p < 0.01). The effect sizes after the first, second, and third interventions compared to pre-intervention in gait speed (d = 0.39, 0.52, and 0.59) and 2MWD (d = 0.35, 0.46, and 0.57) showed a gradual improvement of gait function at every intervention. The results of the present study showed that gait function of chronic stroke patients improved over a year with periodic gait training using the HAL every few months

Effect of riboflavin deficiency on development of the cerebral cortex in Slc52a3 knockout mice

Riboflavin transporter 3 (RFVT3), encoded by the SLC52A3 gene, is important for riboflavin homeostasis in the small intestine, kidney, and placenta. Our previous study demonstrated that Slc52a3 knockout (Slc52a3−/−) mice exhibited neonatal lethality and metabolic disorder due to riboflavin deficiency. Here, we investigated the influence of Slc52a3 gene disruption on brain development using Slc52a3−/− embryos. Slc52a3−/− mice at postnatal day 0 showed hypoplasia of the brain and reduced thickness of cortical layers. At embryonic day 13.5, the formation of Tuj1+ neurons and Tbr2+ intermediate neural progenitors was significantly decreased; no significant difference was observed in the total number and proliferative rate of Pax6+ radial glia. Importantly, the hypoplastic phenotype was rescued upon riboflavin supplementation. Thus, it can be concluded that RFVT3 contributes to riboflavin homeostasis in embryos and that riboflavin itself is required during embryonic development of the cerebral cortex in mice

Wind Tunnel Testing on Start/Unstart Characteristics of Finite Supersonic Biplane Wing

This study describes the start/unstart characteristics of a finite and rectangular supersonic biplane wing. Two wing models were tested in wind tunnels with aspect ratios of 0.75 (model A) and 2.5 (model B). The models were composed of a Busemann biplane section. The tests were carried out using supersonic and transonic wind tunnels over a Mach number range of 0.3≤M∞≤2.3 with angles of attack of 0°, 2°, and 4°. The Schlieren system was used to observe the flow characteristics around the models. The experimental results showed that these models had start/unstart characteristics that differed from those of the Busemann biplane (two dimensional) owing to three-dimensional effects. Models A and B started at lower Mach numbers than the Busemann biplane. The characteristics also varied with aspect ratio: model A (1.3<M∞<1.5) started at a lower Mach number than model B (1.6<M∞<1.8) owing to the lower aspect ratio. Model B was located in the double solution domain for the start/unstart characteristics at M∞=1.7, and model B was in either the start or unstart state at M∞=1.7. Once the state was determined, either state was stable

Continuous Flow Synthesis of ZSM-5 Zeolite on the Order of Seconds

Zeolites have typically been synthesized via hydrothermal treatment, a process designed to artificially mimic the geological formation conditions of natural zeolites. This synthesis route, typically carried out in batch reactors like autoclaves, takes a time so long (typically, on the order of days) that the crystallization of zeolites had long been believed to be very slow in nature. Long periods of hydrothermal treatment also cause a burden on both energy efficiency and operational costs. Recently, we have reported the ultrafast syntheses of a class of industrially important zeolites within several minutes.[1,2] Further shortening the crystallization time to the order of seconds would be a great challenge but can significantly benefit the mass product of zeolites as well as the fundamental understanding of the crystallization mechanism