Outer membrane vesicles of Porphyromonas gingivalis : Novel communication tool and strategy

Extracellular vesicles (EVs) have been recognized as a universal method of cellular communications and are reportedly produced in bacteria, archaea, and eukaryotes. Bacterial EVs are often called “Outer Membrane Vesicles” (OMVs) as they were the result of a controlled blebbing of the outer membrane of gram-negative bacteria such as Porphyromonas gingivalis (P. gingivalis). Bacterial EVs are natural messengers, implicated in intra- and inter-species cell-to-cell communication among microorganism populations present in microbiota. Bacteria can incorporate their pathogens into OMVs; the content of OMVs differs, depending on the type of bacteria. The production of distinct types of OMVs can be mediated by different factors and routes. A recent study highlighted OMVs ability to carry crucial molecules implicated in immune modulation, and, nowadays, they are considered as a way to communicate and transfer messages from the bacteria to the host and vice versa. This review article focuses on the current understanding of OMVs produced from major oral bacteria, P. gingivalis: generation, characteristics, and contents as well as the involvement in signal transduction of host cells and systemic diseases. Our recent study regarding the action of P. gingivalis OMVs in the living body is also summarized

Outer membrane vesicles of Porphyromonas gingivalis: Novel communication tool and strategy

Extracellular vesicles (EVs) have been recognized as a universal method of cellular communications and are reportedly produced in bacteria, archaea, and eukaryotes. Bacterial EVs are often called "Outer Membrane Vesicles" (OMVs) as they were the result of a controlled blebbing of the outer membrane of gram-negative bacteria such as Porphyromonas gingivalis (P. gingivalis). Bacterial EVs are natural messengers, implicated in intra-and inter-species cell-to-cell communication among microorganism populations present in microbiota. Bacteria can incorporate their pathogens into OMVs; the content of OMVs differs, depending on the type of bacteria. The production of distinct types of OMVs can be mediated by different factors and routes. A recent study highlighted OMVs ability to carry crucial molecules implicated in immune modulation, and, nowadays, they are considered as a way to communicate and transfer messages from the bacteria to the host and vice versa. This review article focuses on the current understanding of OMVs produced from major oral bacteria, P. gingivalis: generation, characteristics, and contents as well as the involvement in signal transduction of host cells and systemic diseases. Our recent study regarding the action of P. gingivalis OMVs in the living body is also summarized

ACSM\u27s 64th annual meeting

American College of Sports Medicine (ACSM)は、世界中の健康・スポーツ科学の研究者が一堂に会する大規模な学会です。本学会に参加して、海外の研究者と直に話をする貴重な機会を得ることができ、また、国際学会で行われている研究分野の広さを感じることができました。さらに、指導者から研究者まで、非常に熱心に、かつ、積極的に討論されていることが印象的でした。本学会での発表を今後の研究に発展させていかなければならないと強く感じました。学会参加レポート(Report of participation

ケンジョウナ コウレイシャ ニオケル ユウサンソ ウンドウ ト レジスタンス ウンドウ ニヨル フクゴウ トレーニング ノ ジュンジョセイ ニカンスル ケンキュウ

博士(スポーツ健康科学)同志社大学高齢者の健康づくり運動には，有酸素運動とレジスタンス運動の複合トレーニングが重要であり，この異なる運動をどのように組み合わせるのが安全で効果的かを検討する必要がある．本研究は，健常な高齢者を対象に，有酸素運動とレジスタンス運動の複合トレーニングにおける順序性が，体力や形態，動脈スティフネスに及ぼす影響について検討した．その結果，動脈スティフネスにおいて運動の順序性を考慮する必要があることが示唆された．The purpose of this study is to examine the effects of exercise order of combined aerobic and resistance training into the same session on body composition, physical fitness, and arterial stiffness in the elderly. Based on our results, aerobic exercise after resistance training reduced arterial stiffness and a difference of exercise order was observed. We suggest that the exercise order may favorably affect arterial stiffness when combined aerobic exercise and resistance training is performed into the same session. Our findings support combined training for health promotion and have important health implications for the elderly

学校間連携・学校－行政連携カリキュラムによる生徒エージェンシーに関する実証的研究 : 地域のウェルビーイングを最大化する，探究的な「町の幸福論」の授業実践を通して

Student agency, the quality and ability for children to autonomously be motivated, think critically, and take responsible actions in their local community, is considered to be a cornerstone in the realization of individual and societal well-being. This research aims to investigate the significance of such an approach by comparing the outcomes of the inquiry-based “community’s well-being” initiatives during language and integrated study classes, conducted for primary 6th-grade students in Kumamoto City, involving their interaction with the local community and municipality to maximize community well-being. By comparing pre- and post-intervention results with a non-participating group, this study attempts to empirically validate the outcomes and reflect upon the implications of these efforts. The results of the statistical analysis show that this initiative, utilizing integrated study classes, positively influenced indices related to community engagement and the value of exchanging opinions with others. However, significant effects were not observed in indicators related to philanthropic attitude, future orientation, and self-efficacy. From these findings, it is concluded that while this initiative contributed to exploring solutions for enhancing community well-being and influencing the valuation of relationships with diverse others, it did not fully realize into implementing community development ideas, thus not leading to a sense of self-efficacy