179 research outputs found
Electron and hole Dirac cone states in-pairs in Ba(FeAs) confirmed by magnetoresistance
The quantum transport of Dirac cone states in the iron pnictide Ba(FeAs)
with a d-\,multiband system is studied by using single crystal samples. The
transverse magnetoresistance develops linearly against magnetic field at low
temperatures. The transport phenomena are interpreted in terms of the 0
Landau level by applying the theory predicted by Abrikosov. The results of the
semiclassical analyses of a two carrier system under low magnetic field limit
show that both electron and hole reside as the high mobility states, being
indicative to the fact that both electron- and hole Dirac cone states should be
taken into account in pairs for having the real interpretation of low
temperature electronic states in iron pnictides, being in contrast to the
previous reports.Comment: 4 pages, 2 figure
Gap Structure of the Overdoped Iron-Pnictide Superconductor Ba(FeNi)As: A Low-Temperature Specific-Heat Study
Low-temperature specific heat (SH) is measured on the postannealed
Ba(Fe_{1-x}Ni_x)_2As_2 single crystal with x = 0.058 under different magnetic
fields. The sample locates on the overdoped sides and the critical transition
temperature is determined to be 14.8 K by both the magnetization and SH
measurements. A simple and reliable analysis shows that, besides the phonon and
normal electronic contributions, a clear T2 termemerges in the low temperature
SH data.Our observation is similar to that observed in the Co-doped system in
our previous work and is consistent with the theoretical prediction for a
superconductor with line nodes in the energy gap.Comment: 5 pages, 4 figure
Evidence for line nodes in the energy gap of the overdoped Ba(FeCo)As from low-temperature specific heat measurements
Low-temperature specific heat (SH) is measured on
Ba(FeCo)As single crystals in a wide doping region under
different magnetic fields. For the overdoped sample, we find the clear evidence
for the presence of term in the data, which is absent both for the
underdoped and optimal doped samples, suggesting the presence of line nodes in
the energy gap of the overdoped samples. Moreover, the field induced electron
specific heat coefficient increases more quickly with the
field for the overdoped sample than the underdoped and optimal doped ones,
giving another support to our arguments. Our results suggest that the
superconducting gap(s) in the present system may have different structures
strongly depending on the doping regions.Comment: 5 pages, 4 figure
Chromosomal Dynamics at the Shh Locus: Limb Bud-Specific Differential Regulation of Competence and Active Transcription
The expression of Sonic hedgehog (Shh) in mouse limb buds is regulated by a long-range enhancer 1 Mb upstream of the Shh promoter. We used 3D-FISH and chromosome conformation capture assays to track changes at the Shh locus and found that long-range promoter-enhancer interactions are specific to limb bud tissues competent to express Shh. However, the Shh locus loops out from its chromosome territory only in the posterior limb bud (zone of polarizing activity or ZPA), where Shh expression is active. Notably, while Shh mRNA is detected throughout the ZPA, enhancer-promoter interactions and looping out were only observed in small fractions of ZPA cells. In situ detection of nascent Shh transcripts and unstable EGFP reporters revealed that active Shh transcription is likewise only seen in a small fraction of ZPA cells. These results suggest that chromosome conformation dynamics at the Shh locus allow transient pulses of Shh transcription
Chromosomal Dynamics at the Shh Locus: Limb Bud-Specific Differential Regulation of Competence and Active Transcription
SummaryThe expression of Sonic hedgehog (Shh) in mouse limb buds is regulated by a long-range enhancer 1 Mb upstream of the Shh promoter. We used 3D-FISH and chromosome conformation capture assays to track changes at the Shh locus and found that long-range promoter-enhancer interactions are specific to limb bud tissues competent to express Shh. However, the Shh locus loops out from its chromosome territory only in the posterior limb bud (zone of polarizing activity or ZPA), where Shh expression is active. Notably, while Shh mRNA is detected throughout the ZPA, enhancer-promoter interactions and looping out were only observed in small fractions of ZPA cells. In situ detection of nascent Shh transcripts and unstable EGFP reporters revealed that active Shh transcription is likewise only seen in a small fraction of ZPA cells. These results suggest that chromosome conformation dynamics at the Shh locus allow transient pulses of Shh transcription
Leiomyosarcoma of the sigmoid colon with multiple liver metastases and gastric cancer: a case report
BACKGROUND: Leiomyosarcoma (LMS) of the gastrointestinal tract is an extremely rare high-grade neoplasm with poor prognosis. For advanced LMS with distant metastasis, the decision as to the choice of the most appropriate therapeutic strategy, including chemotherapy and surgery, is difficult. Here, we present an unusual case of LMS of the sigmoid colon with liver metastases and gastric cancer. The survival of this patient was prolonged by a combined modality therapy involving chemotherapy and surgery. CASE PRESENTATION: A 66-year-old woman who had been diagnosed with advanced gastric cancer and multiple liver metastases was referred to our hospital. The initial treatment with docetaxel and S-1 considerably reduced both the gastric cancer and liver tumors; consequently we performed surgical resection. Pathological examination revealed that no viable tumor cells remained in the stomach and chemotherapy resulted in complete remission of the gastric cancer. The liver tumors were immunohistochemically diagnosed as LMS. A tumor of the sigmoid colon was subsequently discovered and the liver tumors were found to have recurred. The surgically resected sigmoid colon and liver tumors were all immunohistochemically diagnosed as LMS. These findings indicated that the multiple liver metastases arose from the LMS in the sigmoid colon, and that they were accompanied by advanced gastric cancer. We performed another surgical resection and administered chemotherapy to treat the recurring liver metastases. The patient survived for 4 years and 10 months after initial presentation at our hospital. CONCLUSION: Colonic LMS is rare and its joint occurrence with gastric cancer is extremely unusual. Although LMS is a high-grade neoplasm, a multimodal therapeutic approach can increase patient survival time even when multiple liver metastases are present
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